Mirtazapine and venlafaxine

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I’ve recently changed from 150mg venlafaxine ir to 150mg er with 15mg Mirtazapine. I’ve been up and down but better than I have felt in months until I increased to 22.5mg and today I feel awful. Anxiety through the roof and really down! Has anyone else had experiences with this combination?

Many thanks 


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8 Replies

  • Posted

    Sorry no I only took mirtazapine but trying desperately to get off it now 

    The withdrawals are brutal so when you do reduce please go slowly 

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  • Posted

    No not really it only worked for a couple of months then the doctors played around with the dose and I eventually was taking 37.5mg which I then reduced but suffered greatly with wd so I was up and down for two years 

    Since 20th December I’ve been reducing from 30mg I’m now on liquid mirtazapine and on 6mg but it’s been very hard you have to taper slowly and be aware not many doctors agree that mirtazapine have wd anyway you have to go to your doctor and just tell him of your concerns as there may be other options 

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    • Posted

      Thanks for the reply 

      I am seeing a specialist in a couple of weeks so I’m going to continue and see how I go.

      Some days I feel good and then I have a bad day and it’s back to square one.

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    • Posted

      Hi Sarah,

      It is what I was told to do but I have been on venlafaxine for years and it has worked for me but they have added Mirtazapine as the venlafaxine hasn’t worked since last August. (They changed from ir to er recently to see if that helps)

      Not sure what to do for the best to be honest. 

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  • Posted

    Hi Chris. I have taken 300 mg venlafaxine and I5 mg mirtazapine since July 2015 and it works great for me. The meds may need more time for the optimum effect. I would contact your doctor and see what he suggests. Good luck.
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