Edited , 14 users are following.
For those of you struggling with your weight loss whilst taking this drug, I thought I’d tell you about my experience and conclusions.
I started on mirtazapine around 4 years ago for major depression and nausea/lack of appetite, and it worked really well for me, banishing my depression within days, and reviving my appetite and enjoyment of food. It also virtually cured my migraines, stopped my itching and IBS, and helped me sleep and cut my temazepam right back to around once a fortnight.
I quickly gained weight which I put down entirely to my increased appetite. I thought all those stories you here about not being able to lose weight despite cutting calories were just people underestimating how much they consumed. I was wrong.
After 6 months on the drug I had gained 26lb and none of my clothes fitted me. Despite cutting my food intake down, I kept gaining weight. In desperation, I came off mirtazapine cold turkey and suffered the most awful withdrawals. After ten days of hell, I was forced to go back on it. But I had dropped 7 lbs. I managed to keep my weight stable at 152-154lbs for two years. I couldn’t eat what I used to eat, but at least I was no longer gaining weight. Then in January this year, I saw a picture of myself in a bikini and hated the way I looked. I decided to seriously slim.
January 2015 I weighed 152lbs and cut my calories to between 1500 and 1800 a day. The weight fell off and I got down to 143lbs by March. I thought once again that mirtazapine was not affecting me being able to slim. I was wrong.
April 2015 I stalled, despite keeping to my diet. So I added a daily cardio work out. I actually GAINED weight!
July 2015 I still weighed in at around 143lbs as I had lost the weight I gained in April but after 7 months was no further on than I was back in March. I was forced to recalculate my maintenance level of calories from 2000 down to 1800. I have an active job and being 5 ft 10, I should need more calories than this to maintain my weight. I realised then that mirtazapine was interfering with either my metabolic rate, or my ability to burn fat or both. I still couldn’t lose any weight.
August 2015 I cut out alcohol which meant that I had effectively cut my calories still further and I have lost a further 2lbs. I now weigh 141 lbs.
Mirtazapine affected my weight by increasing my appetite AND by some other means, probably slowing my metabolism and interfering with my fat burning process. You CAN lose weight on mirtazapine, but it is much harder than if you are not on it. Is it worth it? Well yes, for me it is. It has turned my life around for the better. I love it, and I hate it. I love it for helping me fight my depression, sleep well, be free of migraines and IBS, and not have to take antihistamines daily for my itching. I hate it for forcing me to stay on a rigid diet with very few indulgences, and for being such a difficult drug to kick.
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