Mirtazapine & duloxetine together "rocket fuel !?"

Posted , 10 users are following.

Hi all, I have recently had a relapse in terms of depression and anxiety and my physchiatrist is going to try me on a combination of mirtazapine 30mg and duloxetine 60mg.  I have been on escitalopram / citalopram for a few years but will be switching to the above.

after a bit of research I have seen that this is referred to as limerick or Californian rocket fuel which is somewhat worrying - does anyone have experience of this combination as I will be stopping escitalopram and starting duloxetine from today (been on mirtazapine for just over a week) so just wondered what to expect ?. Thanks all any responses welcome 

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12 Replies

  • Posted

    I know mirtazapine made me gain 3 stone. Made me clumsy (first 2 months or possibly more) and made me angrier than I've ever been. Also made me vomit every time I tried to cut down.  It has a long half life, that's why I wanted it over citalopram, which I tried first, and suffered if I didn't take the pills at similar times each day, but the withdrawal from mirrazapine is horrendous. The benefits: increased appetite, reduces the vomit stress thing definitely, regulates my sleep well, and I have amazing vivid dreams, often with vertigo for me, but the flying on horse and snowboarding down shear cliffs, who wouldn't  get vertigo, kind of worth it. 

    Other than that, the other drug I have never had, so no idea. 

    If you post more tj

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    • Posted

      If you post more though it will be good to hear what you decide. (Sorry this site is terrible with my phone). And it will help others too. All the best. 
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    • Posted

      thanks for the information, im currently on day 3 of the new medication and very up and down at the moment. My anxiety seems to be raised but I suppose that is to be expected. Will let you know how it goes though so thanks and best wishes 
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  • Posted

    Hi Gareth. It is some time since you made this post, but I have just started on this combination and was wondering how you had got on with it? 
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    • Posted

      Hi Gillian it's been 2 years since you started your combination of mirtazapine and cymbalta. How is it working for you?! I was just wondering as my psychiatrist just perscribed me the cymbalta today and I have already been on mirtazapine for a month now. Plz all info is greatly appreciated thank you.

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  • Posted

    Hi,

    I know this is an old discussion, but i will post my experience in case anyone finds it useful. 

    I have had stress problems, minor depression, insomnia, and major psychosomatic problems. In the past I have taken Fluoxetine.

    I have been trying with my doctor, mirtazapine 15,30, cymbalta 60, and both smile

    Mirtazapine, got me out of huge problems with insomnia, when you start it you sleep really really well, negative side effect, I gained 8 kilos. Mood a lot better but sometimes some stress symptoms were worse and the psychosomatic problems were unaffected. I just felt it was kind of wrong for me. 

    Duloxetin for me is a life savior, i just feel its like I am not taking any medication at all. It is the only that relieved me from psychosomatic problems like diarhea, back pains etc. I probably helps sleep a bit too. The only problem is difficulty in having an orgasm sometimes (ejaculate, not get an erection).

    Together they had an even stronger effect in the positives, but mirtazapine is impossible to stop due to the sleep it affects, once I stop it and try to sleep, its impossible.

    As a conclusion, taking them together helped in my case, had some sideffects like weight gain and was very difficult to make my sleep natural again. 

    As mentioned above, duloxetin was life saving.

    Its important to understand that these kinds of medication have different effects on each particular person, one may vomit from mirta other may not, one might say its perfect, one might say its the worst experience of his life. In my case I am only taking duloxetin now and never going to take mirta again. 

    This is why there is always a trial period, trust your doctor but also your body/yourself. 

    Regards

    T

     

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  • Posted

    How are you doing on mirtazapine and duloxetine Gareth?! Just was wondering because the hey just perscribed me that today.. please help me and tell me ur experience as I am very nervous about being nauseous on the cymbalta:dulxoxetine.
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  • Posted

    Hi Gareth, I take these 2 medications together and have so for the last 3 months. The mirtazipine I was prescribed to help me sleep so I take that at nighttime. The duloxetine I take 60mg in the morning and I'm now back to my normal happy self. I was a total mess at the start of taking these meds and would say that they have saved my life. How are you doing on the combination? Xx

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  • Posted

    I've been on Mirtazapine for approx. 6 weeks now with no noticable improvement in my condition (depression & anxiety). I initially started on 15, then 30 and for the past 2 weeks I've been on 45 but unfortunately I'm still waiting for 'something' to happen. It does give me wierd dreams now & again and a bit of an appetite (I could do with putting weight on to be truthful) but I was hoping to see some improvement by week 6 ? Anyone else on Mirt' and how did you find it ?

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    • Posted

      Hi, I am glad that I saw your post. I have been on mirtazapine for about a year and a half . Started 15, then 30 and then 45mg. I don't think that they have helped me. I have no appetite and I could also do with one. I get the weird dreams, sometimes nightmares. I would go back to your GP in a few weeks if you have not already been. It would be great to hear how you got on.

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