Mirtazapine - Making a Liquid to help tapering

Posted , 4 users are following.

It is advisable to taper no more than 10% per month, or 5% every 2 weeks. Or listen to your body - if WD symptoms are present wait a little longer. This slower method is possible by making a liquid solution. Tapering to less than 1 mg may be necessary to enable a secure landing, 0.9 mg to 0.1 preferably for the sensitive.  Or even 0.1 mg every other day for a few weeks:


Here is the pill to liquid instruction for anyone who might want to taper slowly.

You will need a 15 ml syringe and also a 1ml syringe with markings on at 0.1ml intervals

A pill crusher (available from Amazon)

Ora Plus suspension (available from Amazon)

A clean medicine bottle or small jar

A small accurate measuring jug or medicine cup with measure on. 


• Crush up 2 x 15mg (or 1 x 30mg) Mirtazapine pills until they are a fine powder (although the outer coating does not grind up as fine as the white Mirt’ powder that is inside, but that's fine. So long as the white Mirt’ is a fine powder.

• Then measure both 15 ml water & 15 ml Ora Plus and pour into the medicine bottle or see the end for receptacle..

• Then pour the powder INTO THE WATER FRIST, and shake it , then add the OraPlus & shake vigorously. So 1ml of the liquid equals 1mg of Mirtazapine. N.B. Mirtazapine is not soluble in water and so you must shake it vigorously every time you take out a dose to ensure you are getting an accurate measure of Mirtazapine.

• Also you should store it in the fridge. It is recommended to keep it no longer than four days.

So from the 30 mg / 30 ml draw up the syringe what you require. 

1 ml of the liquid = 1 mg.  So if you want 25 mg draw up 25 ml etc.

This has been tried and tested and works very well. Just make sure you shake it very well before drawing up the syringe.

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Using SOL TABS, similar to the above:

Sol Tabs can be very useful if you are withdrawing, or maybe even if you are changing doses.

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I use the OraPlus and yes, it tastes yuck! Important is to suspend the tablet in a bit of water first. I do 50% water, mix and then add the OraPlus, and it still keeps it well suspended so able to stretch the $. If you add the tablet to just Ora Plus, I have found it makes a white glob, hard to mix! You could maybe try Karo Syrup which is thicker than maple syrup. I use these tubes to mix in because they have the hash marks on the tube and you don't lose volume trying to transfer from measuring to your container: 

The markings do wear off after many uses so good to have the supply!

I'll add that for those who want to use just water, even the SolTabs will settle quickly, so I do think it is necessary to use something to keep it in suspension. The other benefit of the Ora Plus is that I believe it has stabilizers in it which would help preserve the integrity of the drug.


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  • Posted

    No need to reply, to be honest I am having difficulty being directed to the site from other users e-mail notifications - anyone else having this problem?  
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  • Posted

    Hi there Calmer

    I thought it was just me but I'm also having problems trying to open the links from email notifications.  It's been like that since Friday

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