Mirtazapine sedative effects 15mg vs higher doses
Posted , 13 users are following.
I have read a few posts on here that 15mg is more sedative than higher doses. My doctor also mentioned this to me but at the time I shrugged it off. How can this be? Surely 30 would be twice as strong as 15? Was there a study on this? Does anyone know please? Thanks
0 likes, 10 replies
clarkio philip14659
Posted
The sedative effects are caused by Mirtazapines anti-histaminics effects, whereas the actual anti-depressive effects of the drug are caused by it's ability to stop reabsorption of Serotonin into nerve endings in the brain. More accurately it inhibits the sensors which monitor how much Serotonin is in synapse gaps which causes the seperate nerve endings to not re-absorb so much Serotonin. SSRIs which Mirtazapine is not work by inhibiting the nerve endings ability to reabsorp Serotonin directly.
Mirtazapine is also thought to have an effect on Noroadrenaline which is where my laymans knowledge ends I'm afraid.
But essentially at 30mg and above you get more of the anti-depressive qualities of the drug which is meant to counteract the sedative effects.
In practice I didn't find much difference between 15mg and 30mg or 45mg but then again Mirtazapine just didn't seem to work for me for whatever reason.
Ultimately if you think the drug might be helping you and you might benefit from upping the dose try it and see how it goes. With ADs it's often a case of balancing the benefits against the side effects.
HTH
philip14659 clarkio
Posted
Canadian__mom clarkio
Posted
I'm bumping my dose of 15 to 30 tonight but I only have 15 mg tablets that melt under my tounge...... If Itake two 15 will it be to strong of a sedative? Do I need a 30pill? Not two 15s? Is there a difference from takingtwo ffifteens over one 30?
tony15730 philip14659
Posted
At 15mg the H1 is pretty much fully blocked so any higher dose will not make you more tired.
However doses higher than 15mg do continue to increase the seretonin and (most importantly to this discussion) the Nor-epinephrine (nor-adrenaline to you and me). So with the extra adrenaline comes more alertness.
So in a nut shell, tiredness maxes out at approx 15mg but the stimulating side continues to increase with higher doses. Thats the therory but individual variation occurs.
philip14659 tony15730
Posted
Canadian__mom tony15730
Posted
Hey! I'm bumping my dose of 15 to 30 tonight but I only have 15 mg tablets that melt under my tounge ..... Should I get 30 mg tablets instead? Or is it ok to just take two 15 ?
London_ridge philip14659
Posted
philip14659 London_ridge
Posted
judy734 philip14659
Posted
Psymon philip14659
Posted
I've been taking mirtazapine for a fair few years now, I find that it works very well for me, but I only recently found out about this sedativity difference between doses.
Makes perfect sense when I read this chat forum
What it got me wondering is...
'does that mean that if I needed a more sedative effect due to a random night of insomnia, then I could ocassionally (not often) take a 15mg instead of a 30mg in order to help me get to sleep???'
And would the same apply the other way round?
'Could a person (taking 15mg) who's feeling particularly lower than they usually feel, decide to take a 30mg or 45mg for one or two nights in order to give their seriton level a quick boost?'
I know it's probably advised against changing dose levels, but would it work and have a noticeable immediate affect in that way???