Mirtazapine withdrawal timeline - help!

Posted , 76 users are following.

Hi, just wondering if anyone can give me some guidance of what to expect during withdrawal from Mirtazapine.

I have been taking 15 mg for about 8 months then tapered to 7.5 for a month and 3.75 for another month. I stopped taking it completely 3 weeks ago. Mirtazapine has helped me with sleep and anxiety to some extent but the weight gain (17 pounds) is more than I was willing to put up with.

I had no withdrawal symptoms during tapering or for the first 10 days after stopping. Since then my sleep has been getting gradually worse and right now can barely sleep at all without sleeping pill. I'm also feeling very tearful and having lots of negative thoughts. My appetite has reduced slightly although haven't lost any weight yet (unfortunately)

So questions for anyone has been through it... When did your withdrawal symptoms 'peak' and then start to get better? How quickly did your ability to sleep come back? And how long did it take you to lose weight gained?

I appreciate that everyone has a different experience, but it would be helpful just to have some idea of what's to come! Starting to feel a bit desperate especially with the insomnia. Thanks

2 likes, 213 replies

213 Replies

  • Posted

    Hi Helen,

    I have recently come off Mirt after being on it for just over a year, firstly 15mg, then 30mg, then back to 15mg.

    I tapered with GP guidance which was a programme of missing doses gradually and having more Mirt free days in between doses. My taper experience went very well and I took my last tablet on May 24th. I was fine for about 4 days and then began experiencing some withdrawal symptoms ie hot flushes, some anxiety, and mainly not feeling too good. This has continued and has been quite horrible to tolerate. Mainly the mornings are the worst. Sleep also I was finding more and more difficult.

    4 weeks on and I think things are slowly beginning to improve - not feeling quite so bad but sleep still not great.

    On the positive side, I did manage to go to the Glastonbury Festival and enjoyed it without too many issues (mainly lack of sleep).

    My weight hasn't really changed yet. I have read that withdrawal from Mirt can peak at 3 or 4 weeks which fits my story. I know now that Mirt has definately benefitted me since my diagnosis, especially for sleeping, but getting off it has proved very hard but I'm gonna hang in there for now.

    I do hope you can too and wish you the best.

    • Posted

      Hi Robert. Thanks for your reply it's so good to know I am not alone! I'm glad you are starting to feel a bit better, it is very frustrating especially with the sleep because it's hard to feel better mentally when you're exhausted. Hopefully that will improve for both of us soon!

      In retrospect, I wish I had also gone down the route of skipping doses, as this might have made this a bit easier. Wondering if I tapered too quickly, I was just sick of dieting and going to the gym 3 times a week and still putting on weight! Although I'm not overweight, it's demotivating not to be able to fit into my clothes Hoping to lose some before my holiday in 2 months.

      Glad you managed to make it to Glastonbury, really good achievement considering! Please keep me updated on your progress, would be nice to hear how you're getting along

    • Posted

      Hi helen:  No you are NOT alone.   Luckily, I read a lot and check here and other forums about withdrawal from Mirt before I started.  Soooo I started weaning by nightly alternating 30 mgs and 15 mgs.  Not too bad.  Next I would take a 30 mg and then 15 mg for two nights and so on until I got down to 15 mgs. at night.  I've been on the 15 mgs. for two weeks and now I'm beginning to feel withdrawal effects.  I'm sleeping OK maybe too much but my anxiety is over the top.  I'm jumpy and irritable.  I've lost my appetite and have low energy.  My ability to focus and concentrate is off and I think I'm seeing things that are not there (like something moving on the floor out of the corner of my eyes).  I almost went back to 30 mgs but I want off this med.  I'm going to stay at 15 mgs for another couple weeks and then try alternating down to 7.5 mgs.  It may take me several months or longer to completely wean off this med.  I know one thing for sure tapering too quickly, is gonna play havoc with your system.  Go slow and good luck.

    • Posted

      Hi frazzled

      Yes it is so difficult isn't it! Sounds like we are in the same boat, it is good to hear from people going through a similar thing smile I never took as much as 30 so you've made a lot of progress dropping a whole 15 mg. I think I underestimated the effect it was having on me and how reliant id become on it for sleep. I think what the previous poster said about skipping a dose every other day and so on might be the key to avoiding the withdrawal, wish id done that! Good luck wishing you the best

    • Posted

      Hi Helen:  Wish me luck because starting Monday, I'm going to try dropping from 15 mgs. to 7.5.  Might end up taking 10 mgs but I'll see how it goes.  Right now (after a month at 15 mgs.,) I'm feeling sleepy almost as much as I was on the 30 mgs so I don't know what's going on).  How are you doing?

    • Posted

      Hi frazzled,can I ask where you are now on your mirtazapine journey?what dose you are on?and any withdrawel effects etc?hoping you are doing well.
  • Posted

    Hi Helen , I was on 15 mg of mirt since October and decided to quit....too quickly so its good to hear you have tapered down sensibly. I stopped within  a few days and started in another AD..Cirtralapram. Lots of negative suicidal thought for. 3 weeks but the new AD is kicking in now and feeling better.  The negativity of thoughts by the lack of sleep was the problem. Mirt offers solid sleep so I am not surprised that sleeping is a very frustrating issue now . I have used zopiclon to at least give me 2 or 3 hours sleep at 3.75mg. Just try and hangon in there as  my sleep is slowly becoming less of a problem. Have you started on a new AD?
    • Posted

      Hi Drew

      Thanks for your reply smile Glad to hear youre feeling better with the citalopram! No I havent started taking another AD yet, I think I probably should do Im just worried about the start up side effects in combination with the withdrawal from the Mirtazapine so i've been a bit scared to! Will probably give it another few weeks. Thats good to hear your sleep has started to improve a bit, how long did that take roughly?

    • Posted

      Hi Helen, My sleeping has improved after 2-3 weeks. Still not going longer than 4 hours before waking up but managing to get off for another couple of hours after that. I don't work so Sleep issue not critical. 

    • Posted

      Hi Helen I have been on both Citalopram 40 mgs and Mirtazapine 30 mgs. I have reduced the Scotsman to 20mgs with some mild withdrawal effects. I started reducing the Mirtazapine by 7.5mg in October but stopped at this in December as I was feeling low. Advised to wait until spring and more light. Have got to 7.5mg by going very slowly. Did experience some vomiting and itchy skin. Been on 7.5mg for 2weeks feeling very irritable. I know this will improve. I want to stop taking it before October. I think it's important to remember it's withdrawal and not necessarily a return of the depression. Good luck with your journey Helen. It will get better than this.

  • Edited

    Hi Helen

    Sorry to read of your suffering after jumping off Mirt.  It was a fast taper, some folks don't get any wd symptoms for 2 weeks then BAM it hits you.  

    I can't say I had sudden symptoms as I did a slow taper, but I did suffer with some protracted rebound insomnia for a period of about 3 weeks, then it settled.  I didn't use any Z sleeping tablets, I just used Phenergen or Benadryl tablets which also contain anti histamine (same as Mirt does) which helped a lot and is available over the counter here.

    Hope this helps a little.  Best wishes.

    • Posted

      Hi Calmer

      Thanks for your reply it's given me some hope that I will start to feel more normal soon! Yes i am starting to wonder if I tapered too quickly, I think i became so frustrated with the weight gain that I wanted it out of my system asap. Not the best idea! I think I might try an antihistamine tonight instead of sleeping pill because I really don't want to get reluant on them. Thanks again for your help, glad to know that things should settle soon

    • Posted

      Hi Calmer, I posted on here last year when I was prescribed mirtazapine

      for problems with nerve pain in my hands and feet. I wanted your opinion

      on withdrawal as I don't feel that this medication is of benefit now. I do not

      take any other meds and wondered if the 10% reduction would still be best

      In my case. Also I wondered if you have had any experience with tinnitus

      when taking this med? 

      Regards, Woodie

    • Posted

      Hi Woodie,

      Welcome back; do you still have the pain in your hands & feet?  

      I can only offer the 10% rule for tapering because it is the only method I tried.  Also I have heard of so many people suffering doing a faster taper.  Maybe if you start with 15 and hold for 3-4 weeks and see how you feel personally, you will know if your body can tolerate that 10%, some do 5% (me too).  

      Yes Tinnitus is common whilst taking Mirt, I had that, still do slightly but don't notice it so much now.

      Hope this helps a little & wishing you well smile  


    • Posted

      Hello again, thanks for replying so quickly. Yes, I still get some pain in my

      feet but to a much lesser degree in my hands. After tests including a nerve

      conduction study the results came back 'unremarkable' and therefore

      inconclusive for small fibre neuropathy. I had quite a big gynaecological op

      in March and wanted to wait till feeling nearly back to normal before embarking on withdrawal from the Mirt. I am finding that with more

      exercise now (walking) I am coping with the burning feeling more and

      if possible want to stop taking this type of medication. As mentioned

      before normal analgesics have little effect on this type of pain😩

      Just hoping the slight head "" 'zinging' "will disappear, never noticed it before!!

      Best wishes....

    • Posted

      Hi Woodie

      Good idea to wait until you have recovered some way after a big op like that, a lot of stress after major surgery ... we women m=need a "wife" to look after us and the house after something so disabling !!  smile  

      What dose of Mirt are you taking now?

      Best wishes for the recovery x


    • Posted

      Hello. I'm taking 15mg. The dr who put me on to Mirt upped me to 30mg

      after a few weeks but I felt 'no extra benefit' and also started getting hair loss

      (my partner thought I was imagining it) so I reduced the dose back to 15mg.

      The nerve pain is so debilitating - I spoke too soon on my previous post -

      perhaps the heat over the last few days has exacerbated things😫

      I've now been on Mirt for twelve months and it's difficult to know where

      to go from here as I couldn't cope with the side effects of other meds. At

      least I mostly get a good nights sleep.... 

      These probs seem to have come on since retirement (last 18 months) or

      was I too busy to notice😲x


    • Edited

      Hello and excuse me for jumping in here, but I wondered if the mirtazapine is causing the nerve pain because I have that as well. It's in my mouth and feet. Is this caused by the mirtazapine? 

      Also, I'm trying to get off this, so wondering how I can do the slow withdrawal ? 

      Thank you 

    • Edited

      I am exploring the possibility of BMS-burning mouth syndrome as the constant tingling pressure and warmth in mouth/gums/tongue fit the pattern. There are a number of sites that offer suggestions for relief. Hope this helps.
    • Edited

      Thanks Paun, just seems strange it has this side effect. 

      But does seem like burning mouth. Mostly my tongue ! 

    • Posted

      10 Weeks off Mirtazapine-Still suffering from sweating, chills, vivid dreams, severe tinnitus, gum throbbing/pain, facial tension, sinus pressure and cold clumsy hands. Things are a little better than last week but still horrific. Still hoping for major improvement.
    • Posted

      I am taking 2 multivitamins & Minerals

      1 vitamin B Complex

      4-6 PPMP ( potassium & magnesium)

      Per day

      I had 3 bad days, now fine.

      Chemicals destroy needed vits & Minerals in the body, it's lack of these that cause long term problems. Go to a health food store, give your body what it needs to repair itself.👍

    • Edited

      Week 11 off Mirtazapine-Still suffering from severe tinnitus, severe sweating day and night, slightly off balance, intense throbbing pressure pain gums/teeth/nose/face/sinuses and dry lip pins and needles. Thanks for the tips about vitamins and minerals and so glad to hear that you are fine. My road has been much longer but I believe I am coming through. I did want to mention a New York Times article titled NYT Exposes Antidepressant Scandal: Antidepressants are Addictive 19April2018. If we stay strong, we can all beat this.
    • Edited

      12 Weeks off Mirtazapine, Still suffering from severe tinnitus, excessive sweating (some) and extreme pressure pain in sinus/face/gums. These are the symptoms that remain of over 50 when I first experienced withdrawal hell. I have been taking supplements and doing facial/neck/sinus pressure point massage. It seems to change the pain but not lessen or eliminate it yet. I still have hope and believe that all of us should too.
    • Posted

      Hello. I have come off Mirtazapine slowly by myself. Was on 30mg,took them down to 15mg, then 7.5mgs then off completly. First week or so was ok then the horrendous hot flashes started and then get very panicky because I am too hot. My tinnitus is driving me crazy. Can I ask what supplements you are taking abs if your withdrawal symptoms are still bad. Thank you and really hope you feel better as this is hell xx

    • Posted

      Hi Jennie

      If you would like to join a FaceBook mirtazapine withdrawal support group, please private message me.

      We can help you.

    • Posted

      I am taking magnesium and B complex. Unfortunately the tinnitus is still quite intense 5.5 months off. Going to chiropractictor who claims that they have heard of this before. I will keep you posted. I truly hope that you feel better.
    • Posted

      Please Jo.r I really need help I sent you a long message on a reply forum. But how do I private message you?
    • Posted

      really need reassurance and support and would like to join this groupl.

      I went off Mirtazapine cold turkey. 8 weeks ago had total nausea for 4 weeks lost a stone. Then anxiety started. At 5 and a half weeks off Mirtazapine I decided to reinstate-went on

      a quarter tablet for 5 days not any better with anxiety. Then went on half a tablet for 8 days. Last Sunday was very poorly with anxiety decided to go on my original dose of 15mg. Have been on it a week now. Went to work 4 days last week. My mind was taken up every single minute with pricing, stocking and serving customers. At the start of each shift I was very poorly but as the day went on I started to feel better each day. I am very very poor on my days off as my brain is not filled every single minute with something to do- tidy, price or stock up. How long will it take before I can get back to normal. I am off today and tomorrow and very poorly as I am doing things but my brain is not occupied every single minute. Please please help

      I didn't see an envelope next to your name .

    • Posted

      hi, can anyone recommend a magnesium supplement to help with withdrawal and insomnia? available in UK. Thank you.

    • Posted

      hi just saw this on the forum. Currently coming off mirt 45mg and trying to find info about withdrawal and how others found it! week 3/4 for me. crappy sleep, itchy hands and feet, unsteadiness and poor appetite are a few withdrawals i am experiencing. is there any way i can be added to the support page?

    • Posted

      hi Paun any updates? i would love to hear if you have recovered now

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