Mitrazapine how long til it kicks in?

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I eventually realised after years of battling with low mood to go on mood stabilisers I chose Mitrazapine iin part for assistance in helping sleep as I dont sleeo too well. So I started taking 15mg on 20th December wanted to allow Christmas time as a time to allow myself to get used to then without them interupting my job. Anyway my mood evened a bit and I wasnt sleeping after a talk with my GP who said if I wasnt sleeping then they werent working I went up to 30mg. I tried 22.5 for  a week but when the7 15mg ran out I went up to 30 which I have been on now for a few weeks, But the last few days I have felt really low trigerred by an event that is a trigger (ill health and not getting to the gym and losing bulk, as I get depressed due to body issues) These last two days I have felt suicidal and really low. How long do they take to kick in?

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6 Replies

  • Posted

    It say two to weeks they said but everybody not the same I have been on for 6 days and I my the same but I was on propranolol as well to keep me calm but I have add to stop taking it because I was getting lots of chest pain so it's my first day off them so it's very hard for me at this time

  • Posted

    They normally work very quickly; much more quickly than other ADs. I noticed a real difference within days, although my sleeping didn't really improve until I had been on them a couple of months at 30mg, but my mood was much better within days. I think you either need to try a different one or increase your dose. If I'm honest though, if you have body image issues, then mirt makes most people put on quite a bit of weight (fat not muscle) and I would therefore avoid it. I'm off the mirt now and have lost all the weight again, but looking back at some photographs of me when I was on it, I looked really tubby. That's not me at all. I have always been slim except when on mirtazapine.

  • Posted

     I take cymbalta with mirtazapine and I feel the cymbalta works better for the depression and the mirtazpine works better for sleeping and just calming me down. So I take 15 mg mirtaz in morning and 30mg mirtaz at night.

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