New Data found on Platelet Rich Plasma (O-Shot) for Vaginal Atrophy and LS

Dr. n. 8 June 19.

The basics of this story are from The Guardian by Kathleen Hale

Dr Charles Runels….. has been called a miracle-worker by the women whose clitorises he has injected with their own blood. But many medical professionals believe the effects are simply placebo – and question Runels’ methods.

Since They will not allow links here, I will say go to the Guardian Website, type in the Search box in the Upper Right "Dr. Charles Runels" Scroll down to "Dr. orgasm will see you now...."

That will bring up a 17 minute video about this doctor in Fairhope Alabama (yes!) who uses platelet rich plasma injected into clitoral and vaginal tissue to rejuvenate those times and in so doing, has greatly improved the LS of the women in the treatment group.

Everyone watch the video carefully.

I am trying to track down the physiological pathway that allows the cells to suffer the auto-immune attack and why the platelet rich plasma offsets the attack but this may be revolutionary. I am trying to track down the two medical journal articles mentioned and will post those findings asap.

Here are the basics of the story as written

When I explained that Runels had actually spent about a year injecting his own penis with blood before shooting up his first clitoris, Gunter laughed. “If people want to do whatever with their own body, have at it. But an untested procedure on your sexual partners?”

As as I could tell, the word “untested” seemed up for debate – according to Runels, it had been tested; using funds from his medical group, Runels had recently financed a $95,000 study to test the effect of the O-Shot on vulvar lichen sclerosus, a dermatological, eczema-like condition which produces cracking and bleeding around the vagina, led by George Washington University faculty member and lichen sclerosus expert Dr Andrew Goldstein.

According to Runels, the results of the study suggest that PRP injections decrease inflammation in women with vulvar lichen sclerosus. (This paper has since been published in the Journal of Lower Genital Tract Disease.) (I am searching for this article)

The O-Shot ranged in price from $1,200-$1,500, and controlled studies have shown that more costly treatments increased the placebo effect – an effect that is so strong, it has been shown to actually create physical improvement in Parkinson’s symptoms.

Studies have shown that more costly treatments increased the placebo effect – and can even improve Parkinson's symptoms

Two of Runels’ assistants, Pamela and Julie, entered to tell me Julie would be getting the O-Shot – right then – so I could witness how painless it was. Julie explained that this wasn’t just for my benefit – that she was 50 years old, had suffered incontinence since having kids and was hoping the O-Shot would help.

Runels hummed his way into the room and after drawing blood from Julie’s arm, he loaded it into the centrifuge and left us alone so that Pamela could lather on the numbing cream. Runels returned to inject the lidocaine into the top crest of Julie’s labia minora – at the point just before it branched into the base of the clitoris.

I waited for Julie to cry out in pain. But instead she just kept talking to Pamela about church. Runels explained to me that this area of the labia wasn’t sensitive (it was built to rip during childbirth) and that bloodflow would naturally take the lidocaine from the labia minora into the clitoris, making a direct injection unnecessary.

Then Runels plucked the vial of her blood from the centrifuge, preparing for the final injection – a direct hit to the clit. The PRP floated on top, yellow and opaque, like dehydrated urine.

While Runels flicked the needle, I ignored the taste of metal in my mouth, squeezed my thighs together and pretended everything was normal. But apparently my secondhand discomfort was unfounded; not only was the whole thing over in seconds, but afterward Julie said: “Is it happening yet?” – because the O-Shot felt like nothing.

“How long will this last?” she asked Runels.

“Conservatively speaking, around nine months,” he answered. He added that, in Lacey’s case, results had persisted for nearly six years.

American Academy of Dermatology website

Platelet rich plasma: Good for whatever ails you?

By Warren R. Heymann, MD

Jan. 13, 2017

Note, here the effect on cellular changes of the platelet rich plasma injection.

The premise behind utilizing PRP is based on its abundance of growth factors including: PDGF (which promotes chemotaxis of macrophages and neutrophils, and is also involved in re-epithelialization, matrix formation, and remodeling), TGF-b (which inhibits macrophage and lymphocyte proliferation, mesenchymal stem cell proliferation, neutrophil and monocyte chemotaxis, matrix formation), FGF (has a mitogenic effect on fibroblasts, endothelial cells, mesenchymal stem cells, chondroblasts, and osteoblasts; it promotes angiogenesis), EGF (which promotes fibroblast migration and proliferation), VEGF (promotes angiogenesis and increases vessel permeability), and CTGF (promotes platelet adhesion, white blood cell migration and angiogenesis; it also regulates collagen synthesis) (1)

Reviewing PubMed revealed that PRP has been touted for oral lichen planus, alopecia areata, pattern alopecia, pyoderma gangrenosum, ulcers (diabetic, livedoid, dermatomyositis-associated, and venous), skin rejuvenation, and scars (acne, striae).

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