Pizotifen almost destroyed our marriage

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I am amazed and horrified to find that this drug is still being handed out to people with out proper supervision and advice. My husband was prescribed the drug a few years ago by his G.P. as his migraines had become more frequent, due to stress at work etc. He changed from someone who had little trouble getting up for work to a groggy, bleary eyed creature. Over the next 12 months he became increasingly belligerent, aggressive and unbearable to be around. He also experienced almost permanent numbness down his left side, like a mini stroke. I was just at the point of leaving this dark, brooding monster who was the antithesis of the funny, loving, intelligent man I married, when it occurred to me that this personality shift had taken place since he'd been taking this drug. Having picked one of his better moments to talk about this, he decided to stop taking the drug to see what happened. Within 24 hours my beloved husband was back. I got hold of the drugs and the information leaflet contained within it and realised that almost every side effect listed applied to my husband. Having been back to the G.P. together to discuss the effect this dreadful stuff had, she thought he should still take it and take anti-depressants as well, no thankyou.

I had always suspected that many of his migraines were triggered by low blood sugar, no breakfast, missing lunch etc. and now he has adopted regular eating patterns in combination with the herbal remedy Feverfew he has only had two migraines in the last year. We were told subsequently by yet another G.P. at the practice that Pizotifen is only supposed to be prescribed for people with debilitating seratonin triggered migraines, that it is a drug of last resort for people who cannot function on a daily basis due to persistent attacks. He also pointed out that not only should it never been given to someone with the level and type of migraine he had, but also as he drives to work every day he should never have been prescribed this drug as it renders you unfit to drive or operate machinery, which the original G.P. should have known but never mentioned. . Thank goodness he didn't come to harm or cause any!!! We recently came across a couple pulling their hair out over their migraine suffering teenage son. He has recently been prescribed Pizotifen and has become so awful that they were considering throwing him out. We couldn't believe that it was happening to someone else and hence I searched out this site. It is a seratonin inhibitor. So unless you have migraines every day and you can't have any kind of life because of them find another treatment. Believe me when I say don't take this drug, not if you love your family.

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4 Replies

  • Posted

    Hi I am a trainer in the NHS. I get migraines and have done for years.

    Recently I was getting one every day and every other. I as dosed up with Ibuprofen and paracetemol and sometimes Imagran to deal with the pain and frequency.

    I have got to my wits end really exhausted mentaly. So I was prescribed Pizotifen 1.5mg. I was like a Zombie I slept virtually all day and had to have that day off. I have had to take a week off work and now seem not as sleepy but no migraines yippee. I have noticed being a bit more bad tempered. Time will tell. One other point I took my motorbike out to go to work and explain in detail the reason for taking a week off work with migraines to my boss. I slipt on ice smashed my bike up and could not walk for three days. Thinking back what a Dick I would never even considerered that usually so I am trying to be more aware of bad decisions.maybe????

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  • Posted

    I do think everyone has different experiences with the medication, and it can work very very well. I wish diet and feverfew would have worked for me...it didn't. My mood hasn't changed. I did have daily migraines, which made me depressed, I couldn't work socialise, eat, drink, read, write, etc etc just carring out a normal daily life was difficult.

    I did alot of research on the drug before I started taking them I knew that driving could be an issue (for some) and all the other known side effects- if they become an issue then manybe it should be stopped. Looking at the side effects after taking them for so long is maybe where things went wrong.

    I do have a few side effects but nothing compaired to the side effects of daily migraines. Please sufferers do not feel worried by the above experience, it is trail and error and it can be simple changes to diet etc.... but this can work and does work.

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  • Posted

    [b:0f9dd8a6bb]In reply to KarenKelly [/b:0f9dd8a6bb]

    I am so glad that someone else has experienced the absolutely dreadful side effects of this terrible drug. I suffer with daily migrains, usually 8 a day until i am in so much pain I can't move (doctor thought I had a bleed in my brain). Was put on Pizotofen. It stopped the migrains within 6 weeks and I was elated. UNTIL, my mood got completely out of control. I started to get seriously angry and wouldnt speak to anyone. My husband was my main target, but, at one point, I almost hit someone over the head and I wanted to kill anyone who looked at me. I had huge fights with my hubby and then had him arrested, even though it was me hitting him, he NEVER laid a finger on me. I told my mother that I hated her and started fights with complete strangers. In the end I took a massive overdose. Obviously I survived, but I have done irreperable damage to my heart. I nearly lost everything because of this drug. It was the worst time of my life and I hate myself for taking it. My husband has stuck by me, but as I am writing this, he has read it and is sitting here in tears at the memory of that dreadful time. It took over a year for the drug to get out of my system and I never recovered from the deep depression that I suffered and have been put on Prozac now. NOTHING is worth taking this drug for.

    You should try it, it does work very well for some people, but be VERY aware of this side effect and if your loved ones notice any negative change in your personality stop it immediately, no hesitation.

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  • Posted

    Replying to TessMich;

    I'm sorry you had such a bad experience, but just reading your story made me immediatly thing that you are suffering from cluster headaches and not migraines. I think you should probably request to see a neurologist in regards to this if you havn't already. They are also known as suicide headaches, as sufferers generally feel so bad they feel like killing themselves!!!

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