PMR question
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my rheumy suspects PMR and I have the classic symptoms. Sudden onset. feel horrible, can't lift arms, extreme pain in upper biceps, severe fatique. Everything else ruled out. Autoimmune runs in family and I have other issues too. problem is bloodwork comes back negative. SED RATE normal range. But 3 days on 15 mg prednisone I am like a new person! Is it unusual to have bloodwork not show Polymyalgia Rheumatica?
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EileenH donna64480
Posted
Up to about 20% of patients with PMR and/or GCA have acute phase markers that are "in normal range". However - that doesn't mean your readings are normal for YOU. My normal level of ESR (sed rate) is in low single figures but for about 5 weeks while I was in hospital some years ago my ESR rant at 16-18 - no-one remarked on it because that was still "within normal range" - and range that is based on results from 10,000 or more patients in a nominally healthy population.
This is a set of links I found earlier for someone with GCA symptoms but normal bloods:
Giant cell arteritis with low erythrocyte sedimentation rate: frequency of occurence in a population-based study.
Arthritis Rheum. 2001; 45(2):140-5 (ISSN: 0004-3591)
Salvarani C; Hunder GG
link.springer.com/article/1...
onlinelibrary.wiley.com/doi...
sciencedirect.com/topics/bi...
emedicine.medscape.com/arti...
PMR and GCA are basically the same disorder just different ends of the spectra. I hope they work, I just copied and pasted and that may not work. If they don't I;ll do them again.
EileenH
Posted
They didn't! Really shouldn't be so lazy! Here you are again:
https://link.springer.com/article/10.1007/s00417-007-0762-7
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0420.2006.00864.x
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/acute-phase-protein
https://emedicine.medscape.com/article/332483-workup