PMR symptoms are similar to my Statin allergic reactions.

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About 7 years ago my Dr placed me on Symvastin because my younger brother ha a quintuple bypass and my maternal side ha heart problems. about a year after starting statins I started experiencing muscle cramps in just about every muscle in my body when I got out of bed in the morning. These cramps persisted for about 2 hours and then I was OK until the next morning. I took myself of statins (the internet is an amazing resource) and my cramping stopped.

I will tell you, that pain and cramps I experienced before GCA and prednisone was very similar to the cramps I experienced with statins. If you are on statins and since we share a genetic desease you could have the same allergy to statins that I have. Discuss this with your physician before altering your medicines. If stopping statins help you, let the forum know. It took me about a week to become pain free but we all know our condition is forever. Damn those Vikings!

 

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  • Posted

    This is very interesting. I am on statins (prevastatin).  But, as I had been taking it for some time before I started to feel bad, I didn't think that it was a part of the problem i.e. the stiffness and pain was totally the PMR; not, perhaps, the combination.  Worth a try.
    • Posted

      This is from the Mayo Clinic at URL: 

      http://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013

      What are statin side effects?

      Muscle pain and damage

      The most common statin side effect is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. For example, you might find climbing stairs or walking to be uncomfortable or tiring.

      Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-mi-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.

    • Posted

      A few experts suspect that the statin action can be the final trigger to develop PMR - the triggers are multiple and probably different in different people and it is a case of the straw that broke the camel's back! And see also my response to cc23145.

      Just because something doesn't start immediately doesn't mean it isn't the medication, though if it starts immediately it is almost certainly the drug (whatever doctors may try to say). Combining pred with certain antibiotics can also cause similar problems (and especially achilles problems) and this is a risk that remains for some considerable time after stopping taking either.

    • Posted

      Very interesting! At my yearly checkup a month prior to my Australia trip, I discussed my statin history with my Dr. and the adverse reaction I had with Symvastin. He recommended Pravastatin which I then started taking. 6 weeks later on a cruise ship I could not stand, I had to roll over and crawl up the wall to get out of bed. I stopped the Pravastatin! My problem is GCA! The year prior to my checkup I had already started having temple pains. I guess we need to see if there are any problems associated with abruptly stopping statins. It might be something some of the readers might want to try for a month or two.

       

    • Posted

      It might be premature to say I do not have PMR as well as GCA because I have not been below 15mg of pred.
    • Posted

      Eileen, tell me about the Achilles problems.  I have recently developed a problem with the Achilles tendon on my one foot
    • Posted

      Certain antibiotics, quinolones, can cause achilles inflammation. In combination with corticosteroids that risk is inccreased. In combination with Medrol in particular the risk is even higher. 

      I was given a quinolone antibiotic and within a few weeks the achilles problems started. I was on crutches for 9 months.

  • Posted

    This is from the Mayo Clinic and can be found by googling "statin-side-effects mayo"

    What are statin side effects?

    Muscle pain and damage

    The most common statin side effect is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. For example, you might find climbing stairs or walking to be uncomfortable or tiring.

    Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-mi-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.

  • Posted

    Thanks for the info. Luckily at this moment in time I am not on statins and am only on Prednisolone for the PMR which seems to be settling down at the moment thanks to earlier advice from the forum. May I wish you all well and good luck.
  • Posted

    I took Atorvastatin for a few years until I developed severe leg pains and my GP told me to stop taking the statins.  It took a lot longer than a week to recover from them.  The other thing that had been happening when I was on statins, was that I kept falling over.  For example, if I leaned forward, I would topple over.  I thought it was something more serious but it appeared to be caused by the statins.

    I had been given them because my cholesterol was high and it did bring that down.  It has gone back up again but has stopped around 8

    • Posted

      My Cousin had a stroke about 6 years ago and the Stroke clinic advised a bowl of porridge every morning to help lower the cholesterol level.  She was also advised to eat a whole orange a day.

      ( why the orange, we have never found out).  However, it worked the cholesterol level dropped to an acceptable level.

      The porridge does not have to be made from scratch,  Oats-so simple does it.

      At the same time a teaspoonful of manuka honey per day helps to boost your immune system and has anti-biotic properties (it must be marked UMF on the label and +5, 10,,12, 15 or 20 (whichever you can afford as its not cheap but well worth it).

       

    • Posted

      The orange is because, like oats, it has a type of fibre that is called soluble fibre. Basically, it binds cholesterol in the gut so it never gets into the blood stream.

      And for the overweight (the lady concerned is absolutely not by the way!) - watch out with oats-so-simple and other "instant" porridges! There is a lot of sugar in them - making your own from scratch but using instant oats rather than oatmeal is just as possible in the microwave. Loads of instructions on the internet.

    • Posted

      CHLO   TRIG.   HDL    LDLCALC    LDLDIR

      150.        54.       50.          89.               92

      These are my Lipid numbers on 8/28/2013. They are all down ~30 from my check ups one year earlier 8/8/2012. A year earlier on 8/2011 the values approximately matched the 2013 numbers. The major difference was caused by an injury which prevented me from putting on my average 2500 cycling miles/year.  The 2012 values started me on Atkins. In the year before the 2013 checkup I didn't exercise and I still lost 25 lbs and lowered my cholesterol. 

      My recommendation, read "Why We Get Fat : And What To Do About It". It is not a diet book!

  • Posted

    Can we clear something up - an allergic reaction is something completely different to an adverse reaction unless it involves swelling of the airways and rashes due to a specific reaction.

    One of the side effects of statins is known to be muscle and joint pains. Simvastatin is said to be the "worst" but that is most likely to be because it has been used for longer than others and is the cheapest. Long after being diagnosed with PMR I was persuaded, much against my will, to take Lipitor (atorvastatin I think) and within 10 days couldn't walk more than 50 yds, less without crutches and even a gentle slope wasn't possible. It took a year to get back to normal.

    • Posted

      Thanks Eileen,  wish I had asked you before about the orange grrr.

      Proper porridge is best, but getting my Cousin to eat is is just a no-no.  And you know how skinny she is so Oat-so-simple does the trick for her.

      I can't stand the stuff, is proper porridge or nothing for me.

      Yes, there are loads of people who complain about the side effects of statins, but never fill in the yellow forms.   The next battle to take on is that NICHE has just recommended that everyone over the age of 50 takes a statin everyday.  So far some Medics are battling against that decision let us hope they win.

      I sometimes wonder if big pharma have a role to play in pushing stuff down people that we just don't need.   Yes if you have a problem, no if you don't.

    • Posted

      I always fill in the yellow forms!!

      [And I eat proper porridge without sugar or salt but with a banana because I can't eat cirtus fruit]

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