Pro D3 20,000 IU Side Effects

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Hi All

Just wondering if any of you can tell me if there are any side effects from taking Pro D3 20,000 IU?

I've been prescribed one of these, 3 times a week, as after a blood test it was noted that my Vitamin D levels are very low. The blood test was a routine test, plus looking at Vitamin B12 and D levels. All other results from the blood test were fine. I suffer from Fibromyalgia, CFS/ME, IBS and Anxiety, and struggle on a daily basis, I am mostly housebound, only managing to get out on average once a week. I'm just interested to see if anyone has any side effects from taking these, as I'm not keen on taking new medication, unless I know it is relatively safe, as I don't want to make myself more ill than I am already.

Any thoughts, views and comments on this would be very welcome and appreciated.

Many thanks in advance.

1 like, 18 replies


18 Replies

  • Posted

    My husband takes 25,000 IU at a time without any problems. Vit D isn't medication as such - it's no different from you taking a vit C tablet if you have a cold really. You may find getting your vit D level back to where it should be will help with the fibromyalgia and CFS symptoms especially since vit D deficit can cause similar symptoms.

    • Posted

      Thank you for the reassuring words Eileen, I'm definitely hoping that taking the Pro D3 has some positive effects, it would be nice to have a bit of a break from feeling so grotty all the time.

  • Posted

    A low level Vitamin D deficiency can lead to a number of non-specific symptoms, including possibly chronic fatigue (experts have for many years noted an association between sufferers of chronic fatigue syndrome or myalgic encephalitis (CFS or ME) and low blood levels of Vitamin D). 

    When you say your Vitamin B12 results "were fine" do you know what the level was? Also was your Folate level tested?

    • Posted

      Hi Clive

      Thank you for your reply

      Unfortunately I don't know the levels my Vitamin B12 are at, I won't know that until my next routine doctors appointment, but I will find out. I will also check to see if my Folate level was tested to, as I can't be sure if it was tested. Is there any specific reason why you mention these tests and levels? I would be grateful to know why you are asking.

      Many thanks

    • Posted

      The symptoms of a Vitamin B12 and/or Folate deficiency are similar to those of Vitamin D.

      If after your present course of Vitamin D supplements all your symptoms have disappeared then they were probably due just to that and I hope you begin to feel the benefit soon..

      I was really interested in what your B12 level actually was when it was tested with the D as often it is flagged as "normal" when in fact it may be "bumping along at the bottom" of the range.

      I wish you well

  • Posted

    Hi Paul. I've been having an extremely difficult time with fatigue! I've had a few serious infections and all I get is "give it time "!!

    I started to research vitamin D and Bella deficiency! My Dr did blood

    tests and sad to say for me they were within the normal range along with Thyroid & Ferritin.

    I found a good website blog site about Vitamin D. You may want to check it out, some of the current talk is about the amount safe to take. I'm not

    allowed to put in the website here but it's a Council of Vitamin D.

    Good luck, Susan

    • Posted

      Hi Susan

      Thank you for the info, I'll definitely look into that website.

      So sorry to hear you are having such a torrid time of late, I can sympathise, I dread getting out of bed every morning cause I know I'll go downhill as the day goes on. I'm fed up with having to rest all the time, especially when before all my problems started I was a really active person. There's only so much rest I can take.

      Its funny you mention infections, as I generally feel groggy and in a lot of pain everyday, but quite often for a few days I get a lot worse, and it really feels like I have some kind of infection going on inside me. I can't ever pinpoint where or what the problem could be related too, I just know something else is going on and it really isn't right. After a few days I go back to my normal levels of illness and pain. I'm sort of lucky that these possible infections never get too serious, I think my days of growing up on farms as a young boy have probably given me quite a good immune system, hygiene is usually the last thing on a young boys mind when feeding calves, cleaning the milking parlour and drinking unpastuerised milk!!

      All the best and I do hope your symptoms ease before too long! Take care!

    • Posted

      I'm assuming both you and Susan have been referred to a rheumatologist as a start? The symptoms you describe, while also possibly due to vit D deficiency, can also be due to autoimmune disorders. Low vit D is common in patients with such autoimmune disorders. GPs/PCPs are often keen to just look at the figures in front of them - but they don't tell the entire story if you haven't asked for the right tests to be done! 

    • Posted

      Eileen, thanks for your response!

      What different kinds of blood tests do you mean? I just had a bunch of blood and urine tests done. I don't know if the Dr. missed any as alot were ordered.

      I love being able to now sign in to see my own test results, sure

      wished that this was available years ago!

      I'm sure that Paul and some of the others would also like to know

      I'll look for your response, thanks, Susan

    • Posted

      In the last two years I've seen a Gastroenterologist, Neurologist and Rheumatologist. I've been tested for autoimmune disorder, hepatitis, HIV (have tattoos), liver and thyroid function, chest and back X-Rays, head MRI, abdominal ultrasound, flexible sigmoidoscopy, colonoscopy, endoscopy, had the 5-hiaa 24hr urine test, stool test for feacal elastase and numerous blood test for things like celiac disease, etc (I've probably missed something out). I think its fair to say that I have had extensive testing done on me, and the only thing ever found was slight inflammation in my bowel during my sigmoidoscopy, and 3 rectal polyps which were removed and found to be benign.

      After seeing all the specialist, and with the testing I've had done my confirmed diagnosis' are Fibromyalgia, CFS/ME, IBS, Gastritis and Anxiety.

    • Posted


      The first would be ESR (sed rate) and CRP - but even if they are normal you can still have an autoimmune disorder. That's why I wondered if your GP had referred you to a specialist - who would do other tests most GPs don't have access to or in some cases probably don't know much about. It is all a detective story really!

    • Posted

      Paul - that seems perfectly fair! You have been well investigated and I doubt they have missed much! Hope the vit D helps.
    • Posted

      Thanks for your response Eileen, I'm a little busier than usual but I'm trying to catch up.

      I will look at my blood test results after this to check out my sed rate, I don't recall if it was in the report or not, I'm sure that it was, all I do know that it wasn't 1 of the elevated or low results

      Recently I've been researching magnesium, I had no idea that there were so many kinds for different problems.

      There are 2 I'm trying to decide between what to try, 1 is for fibromyalgia, which I don't think I have, the other to get fat moving out of the cells. They sound like they both are for increasing energy and decreasing fatigue so I have to read it again.

      Thanks again for responding so I will look into it. Susan

    • Posted

      Magnesium is magnesium - and you can't make it go somewhere specific! It will be absorbed and get into the blood as magnesium ions - irrespective of packaging in the pill. There may be other stuff that MAY have an effect but don't belief the guff on the outside of the packs from health stores or online.

      There are no magic pills to increase energy, move fat out of the cells - or cure fibromyalgia. The salespersons would have you believe it - because they get away with charging more! There are individual versions of nurofen which claim to be the magic bullet for period pain, for headache, for joint pain, for muscle pain, for colds and flu. They are all identical, and identical to the basic (cheaper) version  - but in some countries they charge more. Buying generic ibuprofen does exactly the same thing. Often at a third of the price...

      Get the cheapest or even just Epsom salts, which you can take in small quantities and use as a foot or whole body bath - magnesium can be absorbed through the skin with no risk of diarrhoea. It won't cure the PMR - but it may help any muscle cramps.

    • Posted

      Thank you for your information, just curious and don't want to sound rude etc but where did you get your information?

      Mine is from a Dr Nibber or says he's a Dr, not a salesperson this time I think, I agree there is no such thing as a miracle pill. Anyway, below is what I read. I just cut and pasted the short form uses.

      I totally get that you basically read everything carefully as it often is untrue. If you can enlighten me, I and anyone else following would love to read. I'd really appreciate any input from you, thanks, Susan

      Magnesium Form - Mg Description and Summary Key Clinical Uses

      Mg oxide - Commonly used in OTC laxatives Laxative

      Mg citrate - Commonly used form – good absorption but still can be laxative Laxative, general magnesium support

      Mg (bis)glycinate - Amino acid glycine has calming effect on nerves Insomnia, restless legs, anxiety, muscle spasm

      Mg malate - Malate increases energy production inside cell Fibromyalgia, muscle pain

      Mg aspartate - helps transport fats inside the cell Chronic fatigue

      Mg taurate - Cardiovascular disease Arrhythmia

      Mg orotate - Hypertension, Congestive Heart Failure, Mitral valve prolapse, Stable angina, Blood vessel elasticity

      Mg theronate - Brain injuries, cognition, memory, focus.

    • Posted

      I studied physiology to degree level and biochemistry was part of my professional studies years ago. I've worked in the paramedical field all my life.

      The second bit of all the names is the salt form. You can't take just magnesium, it has to be in the form of a salt.

      What you usually get here where I live is probably magnesium citrate as it is soluble and you can make a not unpleasant drink to take it easily. Magnesium oxide is a white chalky suspension that used to be called milk of magnesia - if you have ever taken it it tastes chalky and isn't very nice. As for the others. I've copied and pasted too to save me writing it myself!:

      "Is one type of magnesium really better than another?

      There are several different types of supplemental magnesium available (e.g. citrate, orotate, malate, oxide, and sulphate). Unfortunately bioavailability studies [how much you actually absorb] typically compare just a few types of magnesium and none directly measure absorption, instead often using urinary magnesium excretion as an indirect marker of bioavailability, which is not very accurate. ....

      ... as the current science stands there is not sufficient evidence to suggest one form of magnesium is superior to another in terms of bioavailability, in fact clinical studies have generally found a variety of forms (in particular carbonate, chloride, citrate, orotate and oxide) able to correct deficiency and clinically effective for a wide range of illness (10). Perhaps any difference in absorption between various types of magnesium is not that meaningful in terms of actual benefits."

      BUT it isn't JUST the magnesium bit

      "An underappreciated factor in magnesium supplementation is the “other half.” Magnesium is typically bound to another molecule, such as citric acid in the case of magnesium citrate, and a number of these secondary molecules have important biological effects that may help guide the selection of a suitable magnesium formulation."

      And that is where the claim comes that this version does one thing and another does another. It isn't the magnesium, it is the glycine, the orotic acid and the malic acid etc that do these things (it is claimed). There is very little in the way of controlled studies to confirm it although some of them have been used in Russia for a long time - but as we know from Ms Sharapova and a lot of other athletes, they use an awful lot of stuff in Russia!

      If you want to avoid muscle cramps the cheapest and most easily available will do the job. Whether the other forms will achieve anything else is debatable and I'm not going to side with one or the other claim. But there is one certain fact! Don't take too much or whichever you take will do the thing they are known for - a good clear out of your nether regions!!!

    • Posted

      PS - in the USA you can buy a Doctorate certificate for a quite reasonable price. I knew someone who had done so (a reverend with delusions of grandeur who was a skilled con artist). It always looks better on a website. I'm not saying he did, I'm saying it can happen.


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