Prozac not working anymore? Help!

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Hi,

My uncle has been diagnosed with PTSD a while ago and he has been taking Prozac for long time. He is living with my grandparents and they told my mom and me that his behavior is changed, like Prozac is not working anymore. Also, they said he has trouble moving, like he is in stupor and has been laying in beds for hours, and his moods are changing often. Is it possible that Prozac is not "working" anymore?

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Thanks for your help!

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