PSA Velocity over 4 months since UTI

Hello. Nothing showed on my other halves MRI either. But biopsy showed as 3+3 cancer. I have read of people on the uk prostate cancer forum of men having MRI and nothing showing up. Then biopsy shows a slow growing cancer, they have chosen prostate removal and when they have been operated on the cancer has spread to nearby tissue.

All I am saying is be careful. All the best.

Sorry, I didn't make that clear...I mean during the operation they find it has spread.

Sounds like good news to me! Be well,

I agree that you should try to rule out a UTI.

Or any other reason for the raised PSA.

And I agree with annual MRI, assuming an expert reports on it.

But if the PSA rises with the UTI under control ( or ruled out) even with the MRI showing nothing suspicious, then you should consider a biopsy.

Yes, I am curious about the PSA rising. Radiologist reported I had BPH, which is in its early stages.But I am still scheduled with urologist in October. I plan to have new PSA in October to see what is happening.

My general doctor said he still thought I had a low grade slow cancer that was not "reportable" via the MRI..yet, but it and the BPH would together start to crank up the PSA...The journey continues.

Geoff 

Yes, agree. Both my doctor and specialist not happy with blind biopsies. They prefer a target. The plan is in October to have a new PSA and urine test. If PSA still rising, then schedule another meeting with Radiologist to recheck the images, based on the rising PSA.

Some thing has to be making it rise. Could be as simple as BPH....then again, it may not be that simple, and a malignant cancer growing, even though slowly and still very low grade as to not change the tissue densities sufficient to flag the MRI.

Geoff 

Glad to hear hat your urologist prefers targeted biopsy.

Ideally a targeted  MRI guided fusion biopsy. This refers to an ultrasound being used with the MRI.

Hi Geoff,

I'm in similiar situation in another post. Last year 6/2015 my PSA was 1.77. In March this year I had a Colonoscopy and doctor found that i have an enlarged prostate. This month i had PSA check and went up to 6.96. I'm wondering if the rapid rise in my PSA 1.77 to 6.96 in a year is somehow related to enlarged prostate or something else. Should i be concerned here? I'm 49 yrs old and so far have no symptoms of prostate problems and water works ok. i'm going to seek urologist soon and will bring up MRI scan before biopsies. I hope the psa spike is BPH or infection and not cancer.

Thank you & God Bless

david

Because I could not get into a urologist for 2 months, I decided to arrange the mpMRI myself. Our Government and private health providers do not subsidise the MRI, so, just as easy for me to do it before seeing urologist. My thoughts were, he will um and ah and say ummm, not sure, we should do a mpMRI and then if anything looks wrong, like in PCa wrong, we will arrange for a MRI guided biopsy....So, I had the scan and results were good for a 67 year old. There is still the question in my mind about high PSA, but common sense says if the mpMRI says nothing reportable, then in all probability, the PSA is caused by the BPH and or a UTI I had and maybe not settled down yet. I will have an 3 monthly PSA and an annual mpMRI. Expensive, but for peace of mind, worth every penny. I am also thinking of getting my urologist to arrange for my entire water works to be checked out and a reference marker of findings established for going forward.

Reading on this forum, there are many guys in their 40's with prostate issues. Their depth of real world day to day knowledge is fantastic. BUT, important for you to get a urologist on your team. For your peace of mind, get a mpMRI on a 3T machine. It is either going to set your mind at rest or point to some thing that needs reviewing.

Geoff 

Well, it is October and I see the urologist next week. Yesterday, I had another PSA test and it has now risen to 13 from 12, 6 weeks ago. General doctor(who also has a rising PSA!!) thinks it is to do with my BPH and maybe a Prostate infection, due to the no PCa mri result. Anyway, on the 6th I will get a better idea and work out where to next.

My younger brother(57) has a similar issue. His PSA had risen to 19.9(from base line of 2.7) over a 12 month period. He has been on antibiotics off and on for 6 months and now his PSA retreating, currently at 3.7. His urologist said his PSA will not return to original score.

Geoff 

I don't like the idea of your brother being on antibiotics on and off. That is not what should happen. If a high PSA is found, then  infection must be ruled out before considering cancer. A course if 14 days if antibiotics is standard.

You say his PSA climbed from 27 to 19.9 in a year. Was the PSA checked every time in the same lab? Different labs have different measuring protocols and are not comparable. You must stick to the same lab for years.

I agree about antibiotics not good if 'on and off', however, most of 2015 I had recurring infections, probably in the bladder neck, which cleared with the standard time at 4 tablets a day, but returned quite quickly again. This year my gp put me on the same antibiotic at 1 a day, once the 4 a day regime had worked, and I continued taking them 1 a day from January to April, then stopped. No sign of infection since (it is now October).

Interesting.This means that different organs are investigated for infection, before considering cancer.

With the bladder being the priority. After all, bladder cancer is more serious than PCa.

Hi barney, My brother used the same lab for his tests. Like me, had a big UTI, had a PSA test and then went on the PSA climb, and after several months and various antibiotics, managed to bring the PSA down. He never had a MRI, only a DRE. 

My mother has bladder cancer and been treated for it now for 20 years. She is 92 and doctors say she is too old now for treatment, so will let it take its course i guess.