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Question for the ladies re + Pap smears & biologics

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Hollaka79
Hollaka79

Hi.

Quick history

Have Crohn’s disease , 30 years now. 

Was on imuran - damaged my liver & didn’t work. 

Went on to Humira - failed

Was on pred for a year - caused Cushing’s 

Tried remicade - worked but severe allergic reaction. 

Due to start Stelera tomorrow, back on steroids but now entorcourt instead of pred, iron transfusion next wk.

Due to go back on aza alongside another drug (alaponal or something like that - usually treats gout but helps split the aza apparently). So a bit hectic (especially last 18 months)

Anyway.... 

20 years ago (aged 19 & on azathiaprine at the time) I had my first positive smear. Several LLTZ, cones & surgeries later they finally got rid of it (CIN 3). 

Now 20 years later, I went for my post pregnancy smear & that tested high grade. Went for my colonoscopy said prob CIN 2-3 again so did the LLEZT again & also tested me for hpv. That came back positive & high risk so wanted to do another colposcopy 6 months later. Went along & Dr said no signs of bad cells & I could go back to my GP & have a regular smear in 6 moths & if normal go yearly. 

Well had my smear 2 wks ago & got a call on Tuesday from my GPs saying I had severe abnormalities & cin 3 & needed to have colposcopy within 2 weeks. Am booked in next wk for that (again).

Now today I was due to go in to hospital tomorrow to start Stelera for my Crohn’s disease, having been on azathiaprine (imuran), Humira & remicade & they all had failed over a period of time, when I happened to mention to my IBD nurse about the latest CIN 3 issue & she said we’d have to cancel the treatment tomorrow & she needs to talk to head gastro. Since then I’ve done my research & seems there’s a link with immunosuppressants & biologics & cervical cancer?  I can’t get how it can come back so quickly & severe in such a short space of time, but the majority of time I’ve been on biologics & immunosuppressants. 

Has Anyone heard of a link between CC & certain medications? 

I’m gonna ask for a hysterectomy next week as it’s getting silly now but was just curious if anyone else had same issues?? 

Thanks in advance 

0 likes, 2 replies

2 Replies

  • stephaney28634
    stephaney28634 Hollaka79

    Posted

    Hi, you been through the wars.  I have had crohn's for 9 years and only have one mild flare up, I have been on Humria injections, they didn't help. I  am on Inflixmab for two years it's helping. Sorry I can't help you.

    • Hollaka79
      Hollaka79 stephaney28634

      Posted

      Infliximab seemed to work, just unfortunately I was allergic to it. All treatments are now on hold until I’ve seen gyn next week & IBD team suggest I should push for hysterectomy so I can continue biologics worry free (ish) x 

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