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I was having leg cramps in calf and thigh 2 to 3 times nightly. It took 10 to 15 minutes of walking around and massaging for relief. Obviously becoming sleep deprived. My doctor started me on 200 mg quinine nightly, increasing to 300 mg if necessary. Within days my muscle cramps diminished. At the end of one month they were gone. The immediate relief was astonishing. I have been on quinine for over a year now. As a preventive dose, I take one 200 mg tablet every other night which seems to be sufficient. If I get an occasional cramp, I take the tablets every night for a few days.
I tried drinking quinine water (Schweppes tonic carbonated water) as a substitute - but was unable to drink that much carbonated water daily. Wasn't able to try it long enough to see if it would help by itself. It had worked for a friend of mine who wanted me to try it.
I have had no side effects from the quinine. I would highly recommend trying quinine if you are having night cramps.
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