ramipril

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I started ramipril, mist sutes say several days to take effect.

For me I got instant drop of 30/10 after a couple of hours and it still is.

Anyone ekse had it working so quickly?

Anyone else ever actually got rid of bo meds with better lifestyle? How long did it take you?

In your exoerience do GPs ever suggest comming of the meds if bp improves ir do you have to take the initiative?

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  • Posted

    Well, I haven't used a mist, but as far as getting off the meds? Yeah, my pc and doctor both were all for getting off them. I got off mine about two years ago, changed my lifestyle and ate better but sometimes there's a need to get back on them. They say you don't get rebound hypertension from stopping ace inhibitors, that's a load of s**t! A spray or mist would be a little hard to ween off of like pills which i had to crush, mix together well and divide so I could get an equal lower dose until I could just stop. Don't get down if you can't get off of the medication though, and I'm totally for getting off of them. It all depends on what your dose is and how high your bp was before you got on the stuff. If it was crazy high and you needed to just lose weight and have done that then there's a whole slew of possible outcomes. I don't know the facts of your situation like what reading got you on the meds, what are they now and such. I will tell you this, beware of white coat hypertension because it's not a myth. What I get at home on my machine is way lower that what I get at the doctors office and I've brought it there just to see if it was accurate. Ten minutes after their readings were 139/83, mine was 152/92. At home 125/75 to 135/82. There are occasions that it pops up to 140/80's. To be totally honest, my "f**k it" button got pushed and I got on a low 2.5 mg dose of lisinopril to keep it within the recommended range. I got my gallbladder out during the two years I was off the pills and now, I wouldn't even know I took one if I didnt remember taking it. Apparently galbladders mess your s**t up, and cause all kinds of issues. I think that's possibly the culprit of a lot of side effects. All it takes is a stone to get caught in the common duct and you can get liver inflammation, pancreatitis and digestive issues from hell. All that went bye, bye after that little piece of crap got removed. Livers good, pancreas is cruising along just fine and I have had no issues with digestion aside from farting a lot but that just means the train is moving. Hope this helped

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  • Posted

    Yes, ramipril as an ACE inhibitor should have some effect within a matter of hours.  It has a half-life listed at 13-17 hours, so the effect should build somewhat over a matter of days, not sure by how much.  I've seen the same thing with ARBs like olmesartan.

    Sure, lots of people manage to get off BP drugs if they lose weight and such, but a lot of others just take them on and off for a lot of years.

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    • Posted

      jx441870...Most leaflets that are in the medicine packages state that the medication begins its work in a few hours, which to me makes sense.  I agree with your thinking of the effect building in a matter of days...it makes total sense. I believe the same is true for ARB's., but not Calcium Channel Blockers. ARB's...Olmesartan, Valsartan (which has recently been banned in many countries), Candesartan, Irbestartan are all ARB's. 

      There are some people who most definitely have their medications reduced or told by the Dr. to gradually taper off completely because their readings are becoming low..some too low. After losing weight, especially if the weight loss is significant, the body adjusts., & therefore, the heart isn't working as hard to pump because of the body weight being reduced. Some however must still take the meds.

      My education about such things taught me that when bp rises, there's something going on in the body, & the rise in bp is telling us that something's going on. Instead of finding out what's wrong., we're given bp medications. You'd be surprised at the number of people out there who think that once you're on bp meds, you're on them for life. This is not true necessarily.

      I have a few pounds that need shedding., so I'm working on it...no more junk food (not that I ate a lot of it). I don't eat red meat., but do eat a lot of chicken with the skin removed. I love salads., & eat whole wheat breads only. Friends tell me to get rid of the wheat, & to be sure to reduce any sugar intake.

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    • Posted

      It's certainly true for some calcium channel blockers, amlodipine has a half-life of 35+ hours so it takes almost a week of normal dosing to build up to the full effects - and it takes two weeks for it to clear out when you stop taking it!  But even that has some effects even after a first dose.

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