Rebound acid from stopping PPIs

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Im a 23 year old fit female, and I decided to stop PPIs which were initially givent to me due to a misdiagnosis.

It's been 23 days since I stopped my PPIs, and i must say I've had plenty of good days, however, I also still have a few bad days (i am more on the silent reflux end). I wanted to know about your experiences coming off. the reason why is because I checked a few studies saying that the rebound lasts up to 3 weeks. Im entering week 4 and I still don't feel fully recovered. took 1 month of omperazole and two months of pantoprazole at high doses. Weaned off in the span of a week (super quickly unfortunately, but I could not handle the side effects anymore).

Thank you for the help smile

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6 Replies

  • Posted

    Hi Sarah,

    I know you talking about. I was on omeprazole for only 7 days and stopped because side effects(upset stomach). I think i am being misdiagnosis too. Doctor thought i have silent reflex which i don't thing i have since i haven't had heartburn. now it is being 9 days since i stopped the medicine and my stomach is burning bad, nausea and loss of appettite. it seems like you are not having bad rebound symptoms. what were you symptoms in the first 2 weeks of stopping the medicine?

    • Posted

      the first couple of weeks were quite hard, 

      my main symptoms were nausea, headaches, eye pressure, fatigue and dizziness, especially after meals. The symptoms would calm down towards night.

      I alternate between good days and bad days. I must say, today being day 23 has been tough. I've had nausea all day and a headache. But it is probably because I had a tea this morning and a french garlic and herb flavored cheese, these ingredients are known to relax the LES.

      I hope we will hear from other people as well!

    • Posted

      Hi Maria

      i would say that with silent reflux you wouldn’t normally get heartburn. I and many others that I know have LPR or Silent Reflux and the main symptoms are in the throat. We have a Facebook group that you should join if not already done so.

      happy to answer any questions.


    • Posted

      Tom, what is your Facebook group called. I have never had heartburn but still ended up with Barretts esophagus etc. No gastroenterologist ever mentioned LPR...
    • Posted


      it is Silent Reflux, Silent GERD, LPR support and chat 

      there is a lot of good support and advice on this forum

      best wishes 



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