Research Findings 6-30-19
Posted , 6 users are following.
Hi All,
Read the article by Perez-Lopez & Vieira-Batista in 2017, vol 20, No 4 issue of Climacteric.
I won't link it because they will delete the post and some of you may find this helpful.
They note that although bacterial/viral theory once was suspected, they do not find support for it.
These authors say we should not use clob more than 240 days a year. They also say biopsies do not necessarily lead to diagnosis.
Also, they discussed white blood cells. When the neutrophils are too high, in comparison to the lymphocytes, then one will have inflammatory T-cells and cytokines that both inflame tissues. The ratio of neutrophils to lymphocytes should be between .78 to 3.53. If you have a recent blood test where you have a WHITE CELL DIFFERNTIAL count, get it out and check it. Find the neutrophil and lymphocyte results and divide the neutrophil number by the lymphocyte number, one should get a result between .78 and 3.53. The neutrophils will probably be 1.8 or 2.4 or something like that and the lymphocytes around 2.0 to 4.0.
Ok, so I dug out my last Dec '18 blood tests and see that my ratio is too low at .72!
The inflammation is usually in response to antigens: bacteria, fungi, viruses, etc... which we know. One interesting anecdotal report was that certain drugs, carbamapezine and aromatase inhibitors are suspected of causing LS. (the latter is an estrogen blocker). By reverse logic then, blocking estrogen brings on LS, then having estrogen prevents or inhibits it.
Also, from pg 340 of article, "Thyroid disease seems to be the most common finding in these patients (12–30%)" AND, "The presence of autoantibodies in LS patients is very common, namely extracellular matrix 1 protein (67%)19, antibasement membrane (BP180 and BP230) (30–80%)20,21, and antithyroid antibodies (9%)22. Autoantibodies can be present in as many as 74% of women22 ." (The 19, 20, 21, and 22 are footnote designations). This is a long involved, but recent (2017) article. There are 96 footnotes that offer more info when I can get to them. These darn jobs sure do interfere with one's personal life.
Now, the question is which antibody is triggering the inflammatory response. The lack of estrogen idea fits well with the two "peaks" of this disease, namely pre-pubertal girls and post-menopausal women. It also fit s with males who, presumably, have little estrogen.
More later as I digest this and some other articles.
best,
biscuit
4 likes, 69 replies
susan43705 Guest
Posted
I have a question to anyone. If ones inner labia are now gone from fusing and the cllt is soon to be fused over, what happens next for LS to go after, the outside labia? There seems to be no end to the appetite of LS.
Nancy_K_B susan43705
Posted
OH, dear sweet Susan... please don't let yourself get too cynical and depressed. Let's all take this as a challenge to up our lifestyle choices to maximum advanced beneficial for humanity. We have to MOVE more often, dance more often, expose ourselves to the sun more often, ditch sugar for the poison that it is known to be. Discover holistic living; slow down and smell the roses... and TAKE VITAMINS and MINERALS that are missing in our food supply... hugs....
susan43705 Nancy_K_B
Posted
Hello Nancy! I'm picturing you with your comment doing an Isadora Duncan dance—a free spirit.
Nancy, you have to admit it is extremely disconcerting to see body parts disappear no matter what one does. LS has not stopped me from having an active life, but it does get me down and it is normal. If it depressed me to the point of not socializing and brooding all the time, that's not good. That is not the case. I've integrated LS into my life with the understanding that things will always be a challenge. Some days more than others. I just want some answers which will probably not happen in my life time.
Continued good health and happiness to you.
Nancy_K_B susan43705
Posted
ISADORA! now there's a name I haven't thought of in a very long time! but what a wonderful free form soul! thanks for the image in my mind...
susan43705 Nancy_K_B
Posted
You're welcome. That is the image I have of you. It's a good one.
Guest susan43705
Posted
Susan, I agree with Nancy on the trying to change one's lifestyle, live holistically where possible and eat better. Perfectly, not possible but we can all change some things.
As to the fusing you have experienced, are you using the clobetasol daily? Once, twice? What vitamins are you taking? A, D (in rather large does), and don't forget zinc because it is essential to so many functions. Have the outer labia flattened out? Are you past menopause? If so, get some estrogen, there are numerous varieties. What about coconut oil in between the drugs?
let me know,
biscuit