Return of PC after brachytherapy

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10 yrs ago my husband had brachytherapy at age 57, since when PSA gradually began to creep up again and last year jumped to 7.5.  PET scan & biopsy confirmed aggressive cancer in prostate & SVs (Gleason 9), probably due to cancer cells being missed in brachytherapy. 

Prostatectomy & further brachytherapy ruled out by oncologist, who said only option is containment for as long as poss by HT (Prostap).  PSA first reduced to 0.4 but now risen to 2.6.  In absence of pain and peeing problems, doctor seemed unconcerned, mentioned ‘PSA bounce’ & changed parameters in path lab (whatever they are!).  Further review in 3 mths.  Obviously not the result we were hoping for.  With all the other treatments mentioned on this forum, we don’t know why he said HT was only option. 

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  • Posted

    Hi Helen,

    I am sorry for your and your husband's health situation.

    As I understand, you are not well served by your urologist. Perhaps you should find another one who will be able to:

    1. Determine the extent of the cancer. This is best done by undergoing a PSMA PET CT scan; and 

    2. Provide your husband with ALL the options available. This is a longer list than the options the urologist can offer or the options available at the hospital he works in.

    I agree with your sense that there must be other options besides hormone therapy. This is not to say other options are better, but at least you should be made aware of them.

    • Posted

      Barney you are probably not in the uk. It isn't always easy to just find another urologist in the uk. Ww often just get what we are given. Unless we have private insurance, which not many people do. Sometimes we can ask for a second opinion but it's not always available. We could only have the standard MRI too. There's no choice of a better machine.

    • Posted

      I hear what you are saying.

      My point is that for those that don't have private insurance, they should weigh up their choices carefully:

      either follow the treatment plan of a urologist you don't really trust OR

      find a high volume urologist attached to a hospital who through different scans can identify the extent if any of the cancer AND whose experience will enable him to offer the best options available. And the best option may mean a shorter treatment period or a very different type of treatment to that being offered by the urologist Helen's husband has been seeing .

      Sure this option may be costly in dollar terms, but a lower cost, in dollar terms treatment could be costly in affecting quality of life unnecessarily.

      Just my 2c

  • Posted

    Sorry for delay in replying – we’ve been away.

    He did have a PET scan in Jan 16 which showed slow growing cancer in prostate with more aggressive type in seminal vesicles.  Gleason: 5+4.  No further spread at that time.We are indeed in the U.K.  I suppose he could ask for a transfer to another local hospital but we don’t know how good their oncology departments are.  The one he’s currently attending is supposed to be a good one, although we haven’t seen much evidence of that yet.  The doctors have given him various information leaflets about the hormone treatment (and one on salvage brachytherapy before telling him that he couldn’t have it) but seem vague and uncaring, and reluctant to answer any questions.   So far we’ve learnt more from the Cancer Research UK and Macmillan websites.

     

    • Posted

      Very sorry to hear about the denial of reasonable treatment you're experiencing in the UK.  That is where we're heading in the USA unless we can manage to stamp out former President Obamanator's "The Tyrant" Care statures, and rid ourselves of the tyranny of the socialist elitest liberals who so disingeniously seek to drag our nation on toward their sick vision of a One World Ameritopia.

    • Posted

      Assuming they're able to watch, I'm sure that both Priminister Thatcher and President Reagan are greatly saddened and dismayed to see the terrible state that both of our respective nations have fallen to.

    • Posted

      Rereading your email makes me think that given your husband has a Gleason 5+4 (a step ahead of my 4+5), Brachy is not the answer. Certainly not Brachy alone.

      Surgery + Radiation or

      Surgery + HT may be the solution.

      The fact that the SV was positive for PCa means more than the prostate bed is problematic.

      And the urologist suspects it has spread beyond the prostate, hence he offered HT.

      The best PET CT scans are those focussed on PCa such as PSMA PET CT scan or similar. These are different to conventional PET scans. I would have such a scan performed to indicate if the PCa has spread to another organ or bone.

      Such a scan will identify other areas that may show evidence of PCa. If say there is just one area, let's say a certain bone, then you should ask a highly regarded urologist or radiation oncololgist if radiation to that bone and radiation to the SV and prostate bed (+\-) HT (presumably HT at a lower dose than if radiation was not applied) is a reasonable treatment.

      If I was in your or your husband's shoes I would explore every option that has a good chance of success before agreeing to any treatment.

       

    • Posted

      Barney I think once someone has had brachytherapy they cannot have it again or radiotherapy as that area has already had the maximum dose. They often won't remove the prostate after brachy either as it is too damaged. Some surgeons will but there is a very high chance of being incontinent, though that would be better than no surgery, but if it has already spread would be pointless. I think I'd be looking into other treatments. 

    • Posted

      You make sense. I forgot that Brachy was already administered.
    • Posted

      Hi Helen, Your Gp can refer you to another urologist in a different area. If you are not happy with your treatment or options. ONE of the drugs mentioned earlier zytiger should now be more easily available in the UK. STAY POSITIVE? My nest wishes to you both.

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