RpL554

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four exploratory studies, inhaled RPL554 is an effective and well tolerated bronchodilator,  , and anti-inflammatory drug and further studies will establish the full potential of this new drug for the treatment of patients with COPD or asthma.

The above statement was copied from a similar but a far reaching  online article about a possibly better treatment for many pulmonary diseases.

Altho the RPL554 findings and benefits  are easily available online, it appears that none of the general run of health professionals,  neither my GP nor any other health professionals that I have asked have ever heard of any new treatments for Asthma or COPD or at least they deny any such product exists,and keep prescribing the normal known treatments for such complaints. My own experience of the usual prescriptions for pulmonary ailments such as my own are very very negative altho I have very little idea what my life would be like without them. My faith in their effectiveness is waning.

As a long term sufferer of COPD my current lifestyle is governed by the various medications available to me. I had no idea (neither did many health professionals) till I googled for some COPD info that a “cure” was already around the corner as it were. I have even offered my services for any testing that needs to be done with RPL554.

I have had this complaint for some years altho it was only comparatively recently that COPD was diagnosed, and ever since the initial treatments did very little good so I then started to look for some other relief of this condition. All I ask is for someone to let me know if there is any release date yet set  for RPL554 to be available on the NHS.

I have written numerous letters to Professionals involved in the research but as yet, I have only had poor  response, but I shall keep writing till I get at least a reply

1 like, 11 replies

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11 Replies

  • Posted

    I have googled this and it is apparently still under trial.  It has not yet been approved for use in the USA or Europe which could explain why your doctor has never heard of it.   Due to the long process of getting a new drug accepted it could be years yet before it is available so don't hold your breath.   It would be great though wouldn't it?
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  • Posted

    Very interesting read. I am not as  yet officially diagnosed with COPD, I have been given 2 inhalers and await results of my perfusion heart scan. I am breath

    ess all the time and have no energy. I am angry with myself that I didn't give up smoking a long time ago. I am smoke free now for 7 days, very pleased with myself but probably too late. My husband has COPD, been in hospital a few times. He has a nebuliser which although is not prescribed to me then I do use every day at some point. Night times are pretty awfull I find, I open my eyes and I'm breathless !

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    • Posted

      IT seems that I have started an avalanche by even mentioning RPL554. please spread the word.
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  • Posted

    Hope we get to hear some good news about this as soon as possible, my condition has deteriated greatly over the last year, I could really do with a little miracle pill,,,to help me breathe,,,,,,and I am sooooooo fed up of cough cough cough continueously ,
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  • Posted

    Extract from articla about clinical trials held abroad and in Manchester-

    Following completion in May 2008 of toxicological studies of RPL554, the Company commenced in February 2009 a Phase I/IIa clinical trial of the drug at the Centre for Human Drug Research (CHDR) at Leiden in the Netherlands. In September 2009, the Company announced that it had successfully completed the trial, demonstrating that RPL554 has a good safety profile and has beneficial effects in terms of bronchodilation and bronchoprotection in asthmatics and a reduction in the numbers of inflammatory cells in the nasal passages of allergic rhinitis patients.

    In November 2010, the Company successfully completed a further trial that examined the safety and bronchodilator effectiveness of the drug administered at higher doses.

    In August 2011, the Company demonstrated that bronchodilation is maintained over a period of 6 days with daily dosing of RPL554 in asthmatics.

    In November 2011, the Company successfully demonstrated safety and bronchodilation of RPL554 in patients with mild to moderate forms of COPD.

    In March 2013, the Company demonstrated positive airway anti-inflammatory activity with respect to COPD at a clinical trial carried out at the Medicines Evaluation Unit (MEU) in Manchester, UK.

    It would seem the trials are not finished yet and, furthermore, when the tests are completed, it would be up to N.I.C.E. to sanction it's use in the UK, and possibly turn it down as "too expensive" as they have done with certain drugs for Altzeimers, even though it only costs about 24p a person. So, as Hypercat said "don't hold your breath" which is a great shame for all COPD suffers.

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    • Posted

      It seem from the responce that I have hit the spot. I have been hammering on for years about RPL554 but it seemed that no one had ever heard of it. yes please plenty of publicity please, it is the only way to get this drug. but I expect it will cost a tad more than 24 pence a go. By the way how did you find about the costings?.
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    • Posted

      It was published in an article on the internet way back which my eldest son read. He was utterly disgusted, as so many people are living older, have worked for so many years in the U.K. and yet are let down by the Government who control N.I.C.E. Not everyone is a suitable candidate, but there are plenty that are..!!
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  • Posted

    Hi Bob.  V interesting post. Why do you say it is a 'cure' for COPD  ?   Did I miss something in the article?  I was thinking it was just another bronchodilator. But I am not medical & may have misunderstood the article
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  • Posted

    May-be what is meant by 'cure' is that RPL554 is supposed to significantly reduce the inflammation caused by COPD.  I am very keen, as a long time sufferer, to know if and when this product will be available to patients.  Is it another way, I wonder, for pharmaceutical to fill their pockets up?  
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