selincro/nalmefene and alcohol

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I drink between 1 and 2 bottles of wine a night. Took my first selincro tablet yesterday afternoon and genuinely didn't feel like I wanted any booze, not sure whether this is psychological or not but who cares, it seems to work. Unfortunately I took the tablet when picking my daughter up from school as I didn't see anywhere that they cause drowsiness so I drove home feeling really spaced out, not good, in fact probably more dangerous than driving after a couple of glasses of wine. I virtually had no sleep last night also. Is anyone else having similar problems?

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  • Posted

    Ive spoken to the manufacturer and they have no idea why this is happening to me , told me to speak to my doctor
    • Posted

      Really? That surprises me a bit. I would speak to your doctor, as advised though.
    • Posted

      I can see this going no where , manufacturer wont or cant help ,my doctor is going to say he doesnt know enough about the drug to advise, Ive spent all afternoon trying to find a linl to Nalmefene and diarrhea and I think there is one ,maybe albeit only 1% chance ,lucky me. Im afraid to take a whole pill as I think I wont survive the adverse reaction in diarrhea and feeling terrible in my whole body
    • Posted

      I understand that. I don't think that your body's reaction is to the drug itself but to the fact that it is breaking down in your stomach when it shouldn't do that until it reaches the intestine.

      However, you mention 1%. I just googled nalmefene diarrhoea (English spelling, not American smile ) and the top result links to a page which says 'Percentage of NALMEFENE HYDROCHLORIDE patients where DIARRHOEA is a reported side effect: 14.2857%.'

  • Posted

    If i were you Bigbee,  I would get a painkiller or vitamin capsule of some sort (not time release)  and pull it apart and empty the contents. I would then put your half or third nalmefene inside and put the two halves back together. Smear it with olive oil and take that  with plenty of water - that should get it all the way down -  and see if you get the same gastro bad effects.
  • Posted

    So today - Busy stressy day at work in London. I normally would have got off the train and gone  into the pub and had maybe three pints. Then I would have got a cab home and probably drunk  a bottle of wine or the equivalent in beer to 'further unwind'  

    I took a nalmefene on the train as I started the 90min journey. I still went into the pub. One pint and made my way home. Two small (honest) glasses of wine with dinner and I am still cool - not obsessed with getting more alcohol in me. . Even  doing some work on PC (hence this post)   Heart beating consciousness still there but not too bad. So good.

    I still sleep restlessley and awake at 4am - but it is a 'pleasant' insomnia - if you know what I mean. I doze peacefully usually - will see how it goes tonight.

     

  • Posted

    I am not having the same affects as you but i have a family member who has been Drink dependant for some time an4 weeks ago he managed to get into a rehab he did his 14 days on these tablets and foundhhelped but theade him drowsy but he does sleep on them. He then decided to go back to the drink and never took the tlets but hen 3 days later decided he was going to give it a 2nd try and has now succeeded but for how long i am unsure. i do know when he takes these tablets they make him sleep alot. I really hope this helps someone and would also love to hear any feedback Please. Jan12 you are not on your own andre is lots of support out there. Have a Nice Christmas and a Happy New year i hope you stick it with some of the side affects

     

  • Posted

    Nalmefene is working so well for me I am amazed.  Three Xmas work parties / meals and probably no more than haf a dozen beers in total. I even found myself throwing away unwanted shots that people had bought me.  Reading all about the Sinclair method and Roy Escapa's "cure for alcoholism" book and it's all fitting into place. It is important you drink when you take nalmefene (one hour before first drink)  which is exactly what I did anyway.

    Last few nights haven't even wanted to drink and have been in a really good mood. 

    I can can see why big pharma and the addiction industry aren't keen. 

    • Posted

      Pleased to hear it is working for you Bunter. I think you meant that it's important that you take Nalmefene before you drink (the opposite way around to how you said it smile )

      I think the reason for the reluctance to use Nalmefene, at the moment, is that alcohol services in the NHS are very under-resourced and limited in what they can offer. Imagine a GP reading that he/she needs to ensure that any patient they prescribe it for must have psycho-social support and knows that there is likely to be a 6 week wait before any referral to the local alcohol service will be dealt with. It goes against the way that most people with drink problems want to be helped. They ask for help now, they need it now.

    • Posted

      Hi Paul and thanks. Yes I wasn't very clear - important to take nalmefene before drinking, ideally one hour before. It works with the drink so it's also pretty pointless taking it if you are not going to drink - UNLESS you are just trying to get the side effects out of the way.  

      Have you seen the the new movie documentary One Little Pill (Claudia Christian) Paul?

      Yes  the NICE psycho support requirement is disappointing. I would reccomend approaching ones doctor with a 2 week drinking diary - show you are serious and say that you are on this (and other forums) where there is plenty of support.

       Private UK online doctors  pharmacies, such as pharmacy2u, are issuing and filling prescriptions! Strange how the profit motive can find a way :-)

    • Posted

      I haven't seen One Little Pill, yet, I keep meaning to find it and watch it.

      I think that the limited amount of alcohol treatment resources offered by the NHS is disappointing considering the long term costs of alcohol problems. Yet again, short-sightedness.

    • Posted

      Hi Paul

      Post got deleted - ridiculous as it was within guidelines. One more deletion and I am outa here.  I will attempt to rephrase:

      A well known online pharmacy seems to get round the 'ongoing support' requirement by referring customers to the nalmafene manufacturer's website where one is supposed to complete a number of modules. I was trying to make the point that it would be simple to have the same / similar option for NHS doctors and prescriptions

    • Posted

      Hi Paul, I saw support this morning and they have agreed to see me weekly and had my telephone appointment with GP who has agreed to prescribe selincro and I'm to collect tomorrow. He is requesting a plan from support because of the monthly expense of £84. I am determined to sort myself out but I am worried about taking them whilst in Company over Christmas because of the side effects others have experienced. Support think it would be ideal if I told a family member but I'm not sure how it would be taken. I will let you know how first tablet goes.

    • Posted

      The main thing you have to avoid is promoting online sales of drugs which are, at best 'dodgy', at worst, illegal and dangerous. I can see where patient.info are coming from with this as they could be on extremely shaky ground. I am sure that they can see that you don't have bad intentions. I have, myself, run an online forum and you have to take ownership is everything your members post.

      When may wife and I were running a local town forum, I found it a thankless task as you get serious hassle from members for trying to avoid legal action being taken against you (AND them!) In the end, with people refusing to understand our difficult position and, my wife in tears, due to the attacks on us for trying to protect ourselves and everybody else, I simply closed down a popular forum one day because I was bo longer prepared to take abuse and have explain repeatedly to people why I had to remove their posts. It was using up hours of our time, some days.

      I can therefore see why patient.info don't attempt to get too involved in long explanations as to why they delete posts. I was in the unfortunate position of bumping into these people in the local supermarket and getting harrassed for trying to do things the right way.

    • Posted

      *my wife (Please can we have the ability to edit our own posts soon!)

       

    • Posted

      Linda. You don't have to tell anybody what medication you are on and why. It should be sufficient to say 'I am taking some medication that causes some string side-effects initially.'

      It may be good if at least one person close to you knows, but you reserve the right to tell nobody at all if that is what you prefer.

      Good luck with it!! smile

    • Posted

      No... This is for you & your family needs to be aware of UR intentions and respect that. Every thing during this time of year is supposed to be joyful. 

      Give that gift to UR family......you will be glad u did!

      if wishes and buts were candy and nuts then Christmas would be scrumptious!

    • Posted

      I think only you can decide when to start them Linda. You should be aware that there is a good possibility that side effects will be strong initially and if, for example, you were going out to see relatives on Christmas Day or having visitors etc, you need to weigh up the pros and cons of feeling unwell, in case you do.

      Bear in mind that it can be about a week before those initial side effects subside. Having said that, if you are more worried about drinking to excess, you should consider that too. You are far less likely to on Nalmefene.

    • Posted

      Hi Linda i think about telling your family is down to yourself and i hope what ever you decided i hope it all goes well for you have a Happy xmas and a good New Year

       

    • Posted

      Hi Linda

      dont get too hung up on potential side effects. For most the effects are minimal, usually a little nausea which passes. Let us know how you get on and have a great Xmas 

    • Posted

      Hi Paul and wow - bad forum experiences!  Don't blame you for getting out. Isn't it strange how people go crazy when they are hidden behind an online persona. Similar when some are in cars too. 

      It is nonetheless annoying to have a post deleted without explanation when the website mentioned is that of the manufacturer of the drug (nalmefene) for which the forum thread is about! 

      Have a great xmas 

    • Posted

      Yes, I see your point Bunter. I tend to tell people what to Google on here now because all posts with links have to be moderated and that delays them going live on the site. Private messages can contain a link without being flagged for moderation.

      Hope you have a good Christmas too smile

    • Posted

      Hello thank you and yes I will keep you posted. Merry Christmas. 
    • Posted

      Hello thank you for the advise but I feeling I am cheating in a way by going off to appointments that my partner or work are not aware of .

      Merry Christmas 

    • Posted

      Thank you for your advice I will give it some thought but not sure if I should experiment whilst being a guest elsewhere. It's a shame I hadn't got them a week ago so am used to them. I'm glad I have people to share with on this site. Merry crhistmas
    • Posted

      Hi Bunter,

      The post was deleted not for mentioning the manufacturer (Lundbeck) but the website you quoted to register with doesn't exist as far as I can see and it did sound like obtaining meds online which we do not allow.

      Paul explained the whole forum thing well so I won't repeat everything except to say if you do have any issues or questions then send me a Private Message. 

      Regards,

      Alan

      PS Paul - I will be chasing the edit facility up in the New Year as a priority.

      Merry Christmas smile

    • Posted

      Thanks Paul - I think I am going to have one of the best Xmas' for a long while. biggrin.  If anyone is looking for the Lundbeck support site - it is -  reduce your dinking without spaces and its a dotcom

      Happy Xmas one and all biggrin

    • Posted

      Hello I hope you had a good christmas? I feel quite flat at the moment and wonder how I can achieve reducing alcohol reduction when socialising is all my new partner does  or eating out and drinking which usually means means me doing the both because he wants to drive! I will take selincro when I have it but not sure how long it takes to have an affect?
    • Posted

      It appears that it takes about a week for people's bodies to become accustomed to Selincro. After that week, the side-effects have normally subsided. Unfortunately, that seems to mean that many people can't just take a tablet the first day they get them and go out, in case side-effects ruin their evening.

      I am not certain that is what you meant, though smile If you mean how long before drinking you should take a tablet, it is recommended that you take one at least an hour before, but I have heard people say that two hours before drinking is better.

    • Posted

      Hi Paul I'm panicking already because I have been copied into letter from GP to support saying prescribing these tabs is only temporary because there is no resourse! What do I do? 
    • Posted

      Hi Linda! Same as my GP. he was however happy to give me a private prescription for Selincro, it cost £62 pounds for 14 tabs. (£4.50 approx. each) Not a lot if it stops you from drinking! I'm about to go for a repeat soon,and will post with any progress!
    • Posted

      Happy new Year Paul its a good job you guys are on this site. I might try teeszy plan and will talk to support about alternative ways to obtain when I go next week. Tomorrows appoint cancelled due to change in hous for new year. I will take first tab tomorrow morning but feel anxious regarding side affects at work but hey ho let's give it a go eh
    • Posted

      Nalmefene has a half life of 11 hours. That means that the amount in your body halves after 11 hours and will have been reducing since the time that you took it). This means that taking one in the morning will have less of an effect if you drink in the evening. You should be aware of that if trying this method. Taking it at lunchtime (say 1pm) might be a better way but remember that this is not what is recommended by the manufacturer.
    • Posted

      Paul makes a good point Linda nalmafene works when combined with drinking. It is best to take it one or two hours before you have the first drink - this is not always made clear on the leaflets or by GPs - they cannot be seen to be encouraging a person with alcohol problems to drink - but that's how it works.  Have a google of the Sinclair method or the movie called One Little Pill. They will  mention naltrexone - but dont get confused - bear in mind that Nalmefene and Naltrexone are both opoid antagonists and work in the same way. Nalmafene is thought to be better, having a longer half life and does not require liver function tests prior to prescription.

      On a personal note - I woke up this morning - new years day - without a hangover. Probably the first in 10 years - :-)

    • Posted

      Hi Paul sorry for abrupt end to last message was sent from work and boss walked in office. It should have continued with I just would like the best advice from you as to what I should do because manufacturers instruction is to take 2 hours before a drink and I didn't know if I should prep my body that's all :-) 
    • Posted

      How goes it Linda? Hope your doc is now OK prescribing. Are you OK with any side effects?

       I have just requested that my doc gives me a 6 month course - on the basis that I can do a little "stockpiling" on alcohol free days. My plan is to get to a stage where I can just have a beer or two or some wine at the weekends - if I chose. biggrin  I will let you know if he plays ball.

    • Posted

      Hello not been brave enough to start yet because of side effects but will do. I like your plan seems s good idea. Let me know how it pans out.
    • Posted

      I've made two straight days without drinking but my heart pounds all night and I have a headache and couldn't sleep last night. Is this normal withdrawal. I've not taken tablets yet? We take when I'm home from work early and not chasing about.
    • Posted

      Ive still not taken a whole tablet as Im afraid to.I was really ill when I took part of the tablet.I know you're not supposed to crush or break them and maybe that was the reason.The manufacturer has been no help ,they refer me to my doctor , who in turn has no experience of the product so wont help
    • Posted

      There are different alcohol withdrawal symptoms, the most common being shakiness, sweating and anxiety (which increases heart rate). Poor sleep pattern is actually something that happens with the alcohol and returns to normal when alcohol is avoided. Most of the symptoms you describe should subside within 3 days of stopping drinking except for the sleep pattern which may take a few more days to get back to a normal sleep pattern.

      Keep going and good luck!! smile

    • Posted

      Thank you Psul I sm trying hard for week days but my problem is when I have one I can not stop!! This why I must start the tabs to help me with this musnt I?
    • Posted

      Yes, Linda, I believe you should start them. Take the bull by the horns and go for it smile
    • Posted

      Hi Paul does it matter how late in the evening I take a tablet as just got home now?
    • Posted

      Hi Paul 3 day no wine so I'm quite pleased with myself but looking forward to weekend and that will be the problemI have seen my support worker today for first time since Christmas eve and my doctor has asked for a plan as he can only prescribe for a total of 6 months. Key worker seems to think that the end result has to be abstinence because you cannot just take these indefinitely just when you go out for rest of life, is that correct? He also encourages me to try taking tablet but only if I am going to drink??

    • Posted

      Hi Linda

      Paul will know far more than me .Apparantly you take the tablets before you know you are going to drink.This supposidly reduces the amount you want to drink .If you have gone dry for three days without meds,the tablets seem ideal,you are getting to a good place

    • Posted

      Hi thank you and yes I am in a better place until I touch a drop and then can't help myself. I am going to try tablet for first time tonight. Wish me luck
    • Posted

      Hi Linda

      If you can go for three days dry ,that is very good ,I cant .If then you want a drink take the tablets and then you are likely to only have one or two glasses by all accounts.You are ideally set.Good luck later and I wait eagerly to hear how you get on.

    • Posted

      Sorry Linda, I am away at the moment with limited time to get online. I would say that you can only judge that by whether it affects how you sleep (one possible side effect) but most people would take it in the evening anyway.
    • Posted

      Sorry Paul but just taken first tab at 6.30 and convinced partner we should go out for drink before tea and I had to force myself to finish first drink and wanted to leave second small glass but was asked to finish it. Amazing but feel odd 
    • Posted

      Well what a strange night that was with me stretching, teeth chattering, insomnia and he ache to name but a few. I feel lousy this morning so hope I can get to work ok? I will continue to see if things improve but at the moment it feels worse than a hangover .
    • Posted

      Just remember that most people's experience is that the side effects get less and disappear after about 7 days.
    • Posted

      Ok Paul I am going to take every day for a week to see. I feel well strange though 😄
    • Posted

      Hi, well now into 5th night with only 1 lge and 1 small glass all week and that was on Wednesday when took first tablet. Tonight will be the challenge as we are going to favourite pub but I will continue with tabs even if I do feel odd. It must be better for people at work as I'm not breathing alcohol over them😄
    • Posted

      Linda ,what do you mean by odd please? Are the symptons lessening yet?

      Good luck ,Im rooting for you !

    • Posted

      Hi ?, the first night was indescribable really and that was tablet with 1.5 glasses wine. I felt somewhat spaced out in pub and although I looked at the drink and my mind wasn't interested I was still physically able to drink it but had no more interest whatsoever. That night I kept stretching out in bed and couldn't sleep with heart pounding but I could deal with it. Last night took tab but no wine and the night was better. Tonight will see what like with a glass and tab. Will keep you posted.
    • Posted

      I know what you mean Linda by the 'not interested' in the drink but coupled with the 'odd feeling'. It is hard to put into words. 

      I still get some insomnia, plus the conscious of heatbeat feeling,  but it's so preferable to the hangovers. Doc has given me a repeat for 6 months although I am only drinking a couple of  beers on 3 or 4 nights a week. For me it's quite important to take the tab a good couple of hours before starting to drink. The 'not interested' feeling is reduced if I take the tablet 30 - 60 mins before. 

      Take care 

    • Posted

      How long has your doctor been happy to prescribe to you and do you just take it on drinking days or every day just in case?
    • Posted

      Well 3 days of tabs now and only 1.5 lgs glaSses of wine and 1 vodka lime and soda. So here goes Saturday which would normally be a biggy for drinking. Not feeling particularly interested at the moment though so let's see.
    • Posted

      Are the side effects subsiding a little Linda?

      It sounds like the Nalmefene is doing what it should.

    • Posted

      Hi Paul yes the side effects are better and yes they are definAtely doing the job thank you. I will keep you posted.
    • Posted

      Hi Linda

      I started mid December and he gave me an initial 28 tabs and has just given me a repeat for 6 months.   I take one just on drinking days but carry one with me at all times in one of those little keyring secret containers.

    • Posted

      Hi sounds a good idea re keyring container. Do you attend support as well?

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