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Whilst undergoing therapy for alcoholism, I was eventually recommened a course of Naltrexone. I thought this might be the miracle cure and gladly signed up, but suffered quite strong side effects - mainly severe drowsiness/sleepiness and irritability. After a few days this began to interfere with my life more than my drinking did, so I stopped taking it and was eventually recommended by my clinic that I try Nalmefene. I gladly agreed, thinking this might finally be the key. The side effects from Nalmefene, however, were unlike anything I could have imagined from any prescribed drug; absolute fatigue/drowsiness, absolute irritability, complete loss of apetite - so much so that I've only had a six inch subway sandwich in 3 days, itself eaten in bites over the course of a day, yet still don't feel in the slightest bit hungry (it also must be noted that I usually eat quite well and have never had any problems that may be associated with an eating disorder). I was unable to leave my bed - when I went to shower I could only go back to bed. When I eventually tested myself to go outside I was literally unable to be there as I found every single thing extremely irritating for no reason and couldn't wait to be back alone in the comfort of my own room (again, I live in a busy part of London and am normally a very congenial and outgoing person). I was in bed for a total of about 35 hours, yet still couldn't sleep properly - though I was 'asleep' it was more akin to the 'sleep' one may have when nodding off on a bus or train only to be jolted awake again, yet only to repeat the process.
Even still, Nalmefene's effect is obscured; through I didn't crave a drink I was so tortured by my solitude - and the racing thoughts induced by it and the drug - that I felt I simply must get out, and so at 11.30pm I went to my local pub. This, to be fair to the drug, was not for the want of alcohol but for a change of setting. Nonetheless, when I arrived and was greeted by friends, I found them all quite irritating and the whole ambience inconducive to my current demeanour (another odd occurrence since they are nice people and this is the same pub I've gone to 4 times a week for 6 years). I wound up leaving, wanting a quiet pint on my own and went to an old man pub down the road, where I sat alone and drank 6 lagers - which would seem to contradict what the drug claims to do.
It should also be noted that while I was on Naltrexone, this urge to keep drinking was quelled.
What I want to ask then, is if anyone else has had similar experiences on Nalmefene? These last few days were, without exaggeration, the single worst days of my life - complete, utter and constant despair, total fatigue, unfounded irritability and complete despondency from the outside world. Combined with zero appetite and recurring nausea, these were days of utter hell, so much so that I have stopped taking Nalmefene because I simply cannot put myself through it again, and reverted to taking Naltrexone again tonight. More worrying is the fact that Nalmefene didn't seem to work - the only reason I wasn't compelled to drink on itnis because I wasn't compelled to do anything at all - exercise, have sex etc, yet once I had a drink the insatiableness of my habit leaked through again. The Naltrexone side effects have so far not shown any symptoms that compares with its counterpart, but it was taken with alcohol, coming off Nalmefene and late at night.
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