Sertraline and Depersonalization

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I've been on Zoloft for almost a month now (started at 25mg and just started 50mg today) and there's been one side effect that has bothered me. I used to have depersonalization before I started on Buspirone a couple years ago, but it eventually went away after I began taking it. Now, it feels like the depersonalization has come back. It's not constant but there are a lot of times throughout the day where I feel totally disconnected to to myself, feeling like I'm dreaming or feeling out of my own body. I can't tell if it's because of the Zoloft itself or because of the extreme fatigue I've been having as well. Has anyone else experienced this while on Zoloft? Has it gone away after a while? I forgot how completely disturbing this feeling was, which also does nothing to help my anxiety.

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    Hi Alex I’ve just seen your forum. I know it’s been 12months but how r u feeling now? Did ure depersonalisation get any better? If so how long did you feel like it. How many mgs r u on❤️
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     I too have constant feelings of depersonalization throughout the day like “ where am I”  or “ is this my body” it freaks me out and I want to lay in bed, I am on 75 mg of Zoloft and .25 mg of Xanax everyday, not sure if I should increase Zoloft as My heart still races every morning I wake up 
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      Hey Redsummergal. I'm feeling exactly the same as you. I'm on 100mg and waking up in the morning is the worst part of my day. Have you improved at all?

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    Hi Alex, I know exactly what you are going through because I’m going through the same right now. I started on sertraline just over a month ago to treat my PMDD pre menstrual dysmorphic disorder. So every time about a week before me period I though I had a brain trumor and had absolutely terrible derealisation and depersonalisation! I lost my dad to brain cancer last year which is probably why. But I started on sertraline 25mg and I was doing great for 3 weeks until I went to 50mg and oh boy was that a mistake I had all the same symptoms you had and just left like I was walking around in a dream all the time it was horrible. My doctor advised me to come off it straight away because it turned out I had serotonin syndrome! Sensitivity to medication is rare but sounds like it happens pretty often. And don’t worry you won’t have a Brain tumor it just the medication messing with your head because as soon as I moved up a dose I had those thoughts as well! I hope you are doing better.

  • Posted

    Yes me to. Ive been taking Zoloft (sertraline) for 12 years now at all different doses and causes bed vision and derealization (almost like being in a dream or glass ball). i hate it and cannot take it anymore. Plus, it does not help with my anxiety/stress. Maybe im to sensitive.

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