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Severe morning anxiety with Sertraline 150mg and Mirtazapine 22.5mg

Posted , 5 users are following.

nicolas77734
nicolas77734

Hello everyone,

I have been on 150mg Sertraline (morning intake) and 22.5mg Mirtazapine (bed time) during more than 12 weeks for depression and anxiety. Mirtazapine was prescribed to help with sleeping. I had terrible up and down with the sertraline but now I do not feel like I am depressed anymore and up and down are barely noticeable. However as soon as I wake up, I get like an adrenaline surge and have difficulty to stay in bed and rest. I have to get up and do something. Each morning is a very hard time for me. During the day, things improve and I am usually really fine during the evening.

My P doc says that Sertraline and Mirtazapine can't interact and produce this adrenaline surge. I used to take Sertraline alone at lower dose during years and never experienced such bad wake up time. So does anyone already experienced similar problem while being on sertraline and mirtazapine?

In advance thank you to anyone who could help me.

 

1 like, 21 replies

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  • weenett
    weenett nicolas77734

    Posted

    I have that just on sert tho, they say its a cortazone or something spike forst thing its horrible isnt it i use 40 mg propanolol to combat this it takes abt 20 mins to kick in
  • krista49686
    krista49686 nicolas77734

    Posted

    Hi Nicolas,

    I was on 50mg for four weeks and felt I was getting more depressed, could have been disappointment. Then a week ago my PA put me on 100mg. I was very shaky in the mornings, and after morning coffee felt manic. I quit drinking coffee and went to black tea. I plan on going on a vegetable juice fast in a few days. I'm hoping to get my bowels to calm down because this side effect isn't much fun. I'm going to give the Zoloft more time because my depression seems to be better.

    I've been on Wellbutrin about ten years, with other antidepressants on and off through the years. I take the Wellbutrin in the mornings, Zoloft around 4pm and Ambien right before I go to bed. I'm a little shaky in the mornings but not as bad as I was.

    Don't know if this helps, but since I was on the Zoloft and a sleep aid too, I thought I'd write you.

    Hope things level out for you 😊

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