Posted , 4 users are following.
I am AA and my wife is AS,and I have four children,two carry the trait(AS),one is Free(AA) and the other one is SS(sickle cell disease),how possible is it? Am confused .I gone through the statistical analysis but could not get out of the disarray.
1 like, 4 replies
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anitalou lab1999
Posted
Hi there - the first thing to do is to be sure that your results are correct. Your children's types are exactly the proportions you'd expect from two parents both carriers. Of course, with small numbers like 4, the proportions do not always work out so exactly, but again, one easy explanation is your results are incorrect, especially if they were done many years ago.
There are also some rare but not impossible genetic reasons why an apparently non-carrier parent could have an affected child, but I wouldn't worry about this at all until you are sure your results are accurate!
lab1999 anitalou
Posted
jenny19687 lab1999
Posted
Are you sure that you and your wife's results are correct? The theory we are told is that if all the facts are as given it is impossible to have a son that is SS. However it's possible that
a) the theory is rubbish or just does not always hold true
b) you and or your wife's blood type is wrong
c) two AS or one SS and any other are bilogical parents of son
if your worried about paternity why not do a DNA test? You can then rule this out and put your mind to rest.
lillie53143 lab1999
Posted
You should probably check whether you have Sickle cell trait too, as it is unlikely from what I've read about to have a son with SS if only one parent has the gene; it makes sense - where would the other S gene come from? If you are certain that you are AA, then as difficult as it is you may want to have a paternity test, and speak to your wife.