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A few months ago when my wife had all problems with the shingles/labyrinthitis episode one of the "baby" doctors at the surgery checked her blood pressure and decided that it was "on the high side". I think it was around 165 over 75 or something like that. Rather than suggesting an initial diet/lifestyle approach to see if that could help reduce the figure she immediately prescribes 5mg Amlodipine daily, These were prescribed as generic 5mg tablets from one manufacturer (Can't remember which)
Everything was fine for the first few weeks with no major side effects to speak of. She then had to renew her prescription and was given tablets from a different generic supplier (Somax) and within a day or so she started to feel pains and cramps in her legs and was generally fatigued. She thought this was probably normal as fatigue is listed as a potential side effect of Amlodipine.
However with her next renewal she was prescribed another generic brand (not sure if it was same as first one) and the fatigue and cramps disappeared. Last week she had another new prescription and was back on the Somax generic offering and within a day or so she experienced the leg cramps and fatigue.
Is this something others have experienced before? Essentially generic actives should all be provided to a BP spec so should not in theory produce different side effects. However could the formulations differ in some way that causes the drug to be delivered at a different rate or be released at a different point in the GI tract?
My wife spoke to the practice nurse last night when she went for her shingles jab and she seemed to accept that differences could occur and to ask the pharmacist to avoid prescribing the Somax version. (Not sure how feasible that is as I gather that they may be required to source the cheapest generic available at any one time)
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