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Some BP and other drugs increase the effect of Statins

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derek76
derek76

Recent findings in America say that the calcium-channel blockers amlodipine, diltiazem and verapamil have all been shown to increase the effect of lovastatin and simvastatin. Amlodipine increases the effect of both statins by 1.76-fold, while diltiazem increases the effect of lovastatin by 3.6-fold and simvastatin by 3.7-fold, and verapamil increases the effect of simvastatin by 2.5-fold.

Antiarrhythmic drugs amiodarone and dronedarone (Multaq, Sanofi Aventis) also have interactions with lovastatin and simvastatin.  

Sirolimus and tacrolimus increase the effect of various statins by anywhere from twofold to 15-fold, according to the report.

0 likes, 3 replies

3 Replies

  • lee12629
    lee12629 derek76

    Posted

    Very interesting and something to definitely consider.
    • derek76
      derek76 lee12629

      Posted

      I use Google alerts to pick up reports on Statins and that was in this weeks batch. No doubt the media will pick up on it next week.

      I was on several of those drugs at the same time as statins three years ago. I had to stop the statins due to muscle pain.

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