Somebody notice anything on Antibiotics + RA treatment ?

Posted , 4 users are following.

Dear everyone,

While on MTX in 2014/2015, I had to take antibiotics at some point (actually 3 times). Back then, I remember I experienced increased joint pain and stiffness during the treatment that would resume 1 week after stopping. Has anyone experienced something similar or have an explanation for this adverse reaction ?

0 likes, 8 replies

Report / Delete

8 Replies

  • Posted

    Hi.... Yes I've had this happen too. My doctor said the antibiotics intevere with methotrexate..

    Report / Delete Reply
  • Posted

    Antibiotics DO interfere with methotrexate - they reduce the amount the kidneys excrete and so the blood level usually increases. Which you'd think might make it work more. Normally you are told to stop taking mtx while taking abx - and obviously stopping mtx will potentially lead to a flare of symptoms.

    Report / Delete Reply
    • Posted

      Thx for your reply EileenH,

      Every time when I stopped MTX, the injection was recent and this stiffness came really fast, after a couple of days, like my whole body was going into a painful stiffness. And I have been wondering why was that and if it was only me.

      When I stopped MTX altogether, I did'nt experience that same reaction. Actually, I had more something like a complete relief. It did'nt last very long of course, but it was something completely different.

      Report / Delete Reply

Join this discussion or start a new one?

New discussion Reply

Report or request deletion

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.

newnav-down newnav-up