Thinking of switching from mirtazapine to citalopram

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Hi All

A little history

I have suffered anxiety and depression previously.

about 4 years ago, i was prescribed venlafaxine 75 mg after 1 day on sertraline, induction was horrible (Restless and trouble sleeping and other typical side effects) and on going side effects weren't great . I was on them for about 8 months and withdraw by tapering slowly.

About 2 years ago i went on to Citalopram for about 8 months 15 mg. I suffered with pretty bad side effects for the first 3 months, i had a dose increase in that time, and come off again by tapering.

I have been on mirtazapine for 12 weeks due to depression , anxiety and not sleeping. The depression and anxiety started again mainly from work stress, but then i get anxiety from things in my past which come around again when the anxiety and depression start again.

I realise that i am going to have to be on something for quite a bit longer this time.

I went on mirtazapine due to them being good for sleep and perseved lower side effects than citalopram. I went on cit the last time due to the venlafaxine start up side effects.

I think that I am pretty sensitive to AD side effects.

My anxiety increased when i first went on mirtazapine, 15 mg, for a couple of weeks and then seemed to get better, but not resolved. After about 5 weeks i increased to 22.5 as the anxiety was still there and mood was not improved. I sleep ok and definitely get to sleep ok ( about 10pm) but am now waking at about 5 am and am taking longer to get to sleep. I don't feel too groggy, but don't feel great during the day but have no appetite and anxiety is increasing again. my mood is still low.

I am wondering what to do.

Is it worth increasing to 30mg , or is it likely that anxiety will increase further with a higher dose.

Should I decrease back to 15 mg but will that not be enough to beat the anxiety and increase mood .

Should back to citalopram as it seemed to work last time but the side effects were pretty bad for 12 - 13 weeks, ( diarrhea and restlessness feeling foggy and some difficulty sleeping, i think i felt pretty fluey for a while too) I'm not sure i want to go back to that but realise that i may not have a choice.

The curent dose of Mirtazapine 22.5mg isnt doing what i want it to and am still anxious (m smoking a lot more cigarettes at the moment) .

Will i have to come off Mirt for a while before switching to Citalopram or can a cross taper be done. Is that likely to horrid also. has anyone had experience of this switch.

I want to get myself settled and sorted out on something that I could take for a bit longer.

Thanks in advance for any guidance or thoughts.

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1 Reply

  • Posted

    sorry forgot to say, I have pretty bad diarrhea on the mirtazapine too.

    the side effects of mirtazapine seem less but it doesn't seem to work as well.

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