tried Azathioprine what next ?

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I was diagnosed with Crohn's Colitis in May this year during a severe flare up. I was put on Prednisolone for 8 weeks during which the symptoms stabilized and am still free of them now.

As a preventative measure I was put on Azathioprine qui t e recently. All was well until day 8 when I came down with flu-like symptoms. Fever aching dreadful lethargy as well as sickness.

I stopped the Azathioprine but agreed to try it again after speaking with the IBD support nurse.

After a break of 5 days I restarted and had a similar reaction 2 hours after taking the tablets. This time all the same symptoms plus diahorrea. I stopped taking the Azathioprine and symptoms subsided within 24 hours.

I am seeing my specialist in next 2 weeks and wonder what might be tried next.

Has anyone had similar experiences with Azathioprine?

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4 Replies

  • Posted

    Hi Pete

    ive had crohns for well over 20 years, and yes I totally had the same side effects, it's crap, I've now been put on to another drug to try, methatrazate (I think that's how you spell it lol).

    so please don't worry, there is always other things to try

    stay positiveĀ 

    lynne x

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  • Posted

    hi pete like you i have chrons,

    like you i had a reaction to azathioprine, its a horriable drug with nasty side affects, i then went on to methortraxate like lyn, i had 16 weeks of injections, and now i take six 2.5mg once a week, i have not had a flare up since this, it also has some side effects, causing nausea, aching joints, and for a few days you feel extremely tired, i also have mouth sores, but its getting used to what you can do, on your good days, my chrons was very severe, hope this helps, its just finding what works for you.

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  • Posted

    Hi Pete

    I also had cramps/aches in thighs and back and breathlessness on aza, more than six months ago, so you are not bonkers!

    It may take several tries before you get a med that gives you relief where the side effects are minor compared to the disease. As everyone is different won't list what I have tried here. My very best advice is don't try and put on a brave face or push yourself too hard , learn to relax in warm bath or meditate, have a good cry when it is unbearable,and tell your specialist everything even if you dont know it is connected.

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