Trying again

Posted , 2 users are following.


I stopped duloxetine/cymbalta over a month ago and am trying it again.

I'm 6 days into the medicine and have increased anxiety and depression. My insides are crying but I can't release anything. I feel awful but am perservering for now. Will be seeing the Psychiatrist in 3 weeks time and hope I can hold on until then.

I wish more people would post on here.

0 likes, 5 replies

5 Replies

  • Posted


    thats exactly how duloxetine made me feel. It didn't seem to help my mood at all, just stopped me from releasing how I felt. In the end I thought I was going to explode!! :? I couldn't talk about it or cry or release any sort of emotion at all.

    I have just come off of the duloxetine and gone onto Mirtazapine for this very reason. I am having terrible withdrawal. How did you cope with coming off it the first time? Id love to hear your experiences, so hopefully Im not totally alone :cry:

    Dont understand why more people aren't posting about duloxetine and their experiences

  • Posted

    Well you wanted more experiences of duloxetine so here goes. I was prescribed 60mg of duloxetine as an add on to the other meds I was on but also to eventually wean myself of dothiepin. I had high hopes for this drug from the outset. I experienced extreme nausea and sickness being sick every night. I had terrible headaches on one side of my head. I had terrible giddiness and would fall over from the bed to the loo! I was on it little over a month and have no plans to back on it favouring inspite of the weight gain mirtazapine instead. I lost half a stone during this period and had to take time off work. I also encountered sexual difficulties which seem to be attributed to the duloxetine. I wanted to give it more time but my psychiatrist took me off it immediately.
  • Posted

    Hi pooh bear

    Thanks for sharing your experiences. It seems to sound pretty similar to my experiences.

    How are you finding the Mirtazapine? I am on my 5th day and feel awful, but like I said im not sure if thats because of the withdrawal of the duloxetine or not.

  • Posted

    wow! replies....this is great!!! :D

    Thanks for replying!!! When I first came off the Duloxetine I experienced the most excruciating muscle pain - and the bizarre thing was that I was only on Duloxetine for 8 days!!!

    Second time round, it's nearly 3 weeks and I still feel awful - infact my depression is a lot worse and my insides seem to be screaming. I'm seeing the Psychiatrist tomorrow and I've made up my mind that I'm coming off. I don't know which way to turn and don't want to keep trying all different meds.

    Right now, I'm so fatigued and just want to stay in bed all day. I feel I'm in a different world from everyone detached and so alone!!!

    Has Mirtazapine worked better for you?

  • Posted

    Hi Squeezy I really wanted the duloxetine to work but unfortunately it did not. The mirtazapine seems to be working quite nicely but last week I put on 3lbs! This week I'm trying very hard not to overeat. I've had a horrendous weekend as I have come off dothiepin at 150mg. Feeling better now. Taking mirtazapine 30mg and lithium 1,000mg.

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