Unexplained severe abdominal issue helped by anti-histamines

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Hello. I've had this experience 5 times in my life now and again today. Really would like to find the cause.

When it happens I experience extreme sharp cramping pain in the bottom right of my abdomen/groin area that radiates upwards. It comes in waves, where it increases in intensity for 30-60 seconds or so and decreases again before the next wave.

I consider myself pretty good with pain but I can hardly move when it happens. The pain is unbelievably intense accompanied with a lot of noise and bloating in the adbominal area, it feels like something really bad has happened.

Eventually this escalates to combine with severe vomitting and diarrhea which had all lasted a day in the past. The last time I tried taking an anti-histamine and within 30 minutes 90% of the symptoms vanished. I tried again this time and it worked again. So I have the temporary fix, but not the cure.

I went to the hospital the first 3 times and they couldn't figure out what was wrong. I had ultrasound scans after and they showed nothing abnormal. My diet has been the same, I eat pretty much the same things every day for bodybuilding. It isn't accompanied with any rashes or hives.

Does anyone have an idea of what could be happening here? Thanks.

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6 Replies

  • Posted

    Has your appendix been checked?  Right sided stomach pain that comes in waves and increases in intensity along with vomiting could point to this.
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    • Posted

      Hmm I guess they did with the ultrasounds but i'm not sure how reliable they are. Surely the antihistamines wouldn't have an effect if it was though? I do notice myself automatically holding my right side under the ribcage at times.

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    • Posted

      Antihistamines may help with inflammation temporarily. You can also get a grumbling appendix which can come and go.  Another possibility is your gallbladder.    All tests have a margin of error.  However, ultrasounds are done regularly, so they must be pretty accurate.


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  • Posted

    It's unfortunately a huge field and not necessarily has to do with the bowel itself, which should be checked first of course!

    X-ray, barium or MRI for physical evidence of partial obstruction. Calprotectin in stool. Scopes. For appendicitis white blood cell count and CRP give valuable clues.

    During an episode the C1Esterase Inhibitor (blood enzyme, quite cheap) could be measured to exclude abdominal angioedema (HAE).

    Porphyria, abdominal migraine are other rarer possibilities, but intense intermittent pain.

    Once those episodes are 'survived', it get's harder to be taken seriously I found unfortunately and the ER won't do a thing, one goes through a lot of specialists and waiting times.

    Best of luck! Please keep us posted.


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