Venlafaxine and Trazodone

Posted , 4 users are following.

I've recently been diagnosed with Major Depressive Disorder and Generalised Anxiety Disorder and i've been prescribed 150mg Venlafaxine and 100mg Trazodone.

Started first couple of days ok but third day I was feeling quite spaced and restless and after a couple of days this got better. Now this has stopped but now i'm having really awful hallucinations.

Has anyone else tried this combination of medication and has anyone had any similar experiences?


0 likes, 8 replies

8 Replies

  • Posted

    I was on that combination for a while - I had started on trazodone and then had venlafaxine added in. I started on 75mg venlafaxine then moved to 150 and eventually 225. I didn't have hallucinations or anything similar to what you described, but they didn't really help particularly either, so I am now taking amitriptyline. Feel free to get in touch if you have any questions.
  • Posted

    hiya leeboy,

    hallucinations can be a sign of Serotonin syndrome :? the combination of venlafaxine and trazodone has been seen to cause Serotonin syndrome in some patients, the combination of these two drugs is USUALLY not recomended :shock: :roll:

    get in touch with your doc imediately leeboy, dont delay, personally i'd be inclined to stop taking the meds until i'd talked to my doc :? :wink:

    did your GP prescribe the meds or a psychiatrist ?? :huh:


    Ken ~~~~~~~~~~~~~~~~~~~~~~~ :cheers:

  • Posted

    Hey thanks for the replies!

    Psychochief, it was my GP that put me on Trazodone 3 months ago and my Psychiatrist put me on Venlafaxine, he said it'll be fine for me to take with Trazodone and he is monitoring my blood pressure fortnightly and i'm being sent for blood tests and a scan at the hospital. I assume the blood tests are to look for any other conditions that might be triggering my symptoms. I dunno, I'll wait and see.

  • Posted

    Hi again

    I was the same, my GP changed me to trazodone (which helped with sleep but not much else) and then my psychiatrist added in venlafaxine. Did you go straight onto 150mg ven? Maybe that's what made you feel quite strange.

    BTW, I also came off ven very quickly and apart from feeling anxious and pins and needles, it really wasn't too bad - I had been reluctant to start taking ven because of all the stories about how difficult it is to get off it, so was glad to find it wasn't too bad.

    Hope you are getting on ok.

  • Posted

    Hey gretchel.

    Yeah I went straight onto 150mg and its increasing to 225mg after 4 weeks, i've not had any other side effects in the past week and a half now which is a good sign, tho I can't see any improvement in my mood yet but i'll give it time. I do have the occasional burst of energy which is a nice change because its motivated me to do more smile

  • Posted

    hiya leeboy,

    nice one, the 'bursts' of energy and motivation to do stuff, the venlafaxines starting to kick in :mrgreen: :ok:

    dont forget tho leeboy, dont overdo it when your feeling 'energised' it'll set you back, you're on the mend, hang on in there, upwards and onwards :wink: :mrgreen:


    Ken ~~~~~~~~~~~~~~~~~~~~~ :cheers: :rainbow:

  • Posted

    I don't know tradozone but if it is a serotonin uplifter then you shouldn't take it with venlafaxine - the same for anything like tramadol (painkiller) or ephedrine based cold cures. Psychiatrists are very well knowledged about drug cures but it might be best to double check with your pharmacist as they are the experts. Forget about GPs they know nothing?!
  • Posted

    My CPN has said that he's gonna ask my Psych (as she's off sick right now) to add 225mg Venlafaxine to my 300mg Trazodone. He said that you can combine these anti-depressants in the same way u can combine Mirtazapine with Venlafaxine. I have severe depression, alongside BPD, and something urgent needs to be done! I hope this is the right decision! Hope u all get the right result from your treatments. T x

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