Vitamin D and your prostate

Posted , 11 users are following.

Interesting study if from 2013 but I haven't found any followup on it yet:

Vitamin D and benign prostatic hyperplasia -- a review.Espinosa G1, Esposito R, Kazzazi A, Djavan B.Author information

Abstract

INTRODUCTION:

Benign prostatic hyperplasia (BPH) is a more common form of lower urinary tract symptoms (LUTS). BPH is due to the excessive growth of both stromal and epithelial cells of the prostate. Fifty percent of men over the age of 50 will have this disease, along with the probability that 90% of men at the age of 80 will have an enlarged prostate. The prevalence of vitamin D deficiency in the male urological population may represent a connection between BPH and vitamin D.

MATERIAL AND METHODS:

This review is geared to provide the most relevant data on the correlation between vitamin D and BPH. A comprehensive review was conducted on all studies on the specific topic and compiled into a complete article.

RESULTS:

Data suggests that vitamin D has an inhibitory effect on the RhoA/ROCK pathway, along with cyclooxygenase-2 expression and prostaglandin E2 production in BPH stromal cells. Increasing intake of vitamin D from diet and supplements has shown a correlation with decreased BPH prevalence. Vitamin D analogues of up to 6000 IU/day have shown to decrease prostate volume in BPH patients. Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone. Among all the studies there has not been any side effects or negative implications with increased vitamin D intake.

CONCLUSION:

The impact of vitamin D on prostate volume and BPH has shown promising results, thus proposing further studies on vitamin D and BPH be conducted.

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  • Posted

    Uncklefester, 

    Tis is interesting as I have had a viamin D deficency for many years. Current blood test show that I am at this time running normal. But, it had been very low for a while.

    Thanks for the interesting input.

    John

    • Posted

      Here's something from the web

      How Vitamin D Can Help with Enlarged Prostate Problems

      The relationship between vitamin D and BPH has been evaluated in a number of trials. One study evaluated 4,770 participants in the Prostate Cancer Prevention Trial who were free of BPH at baseline. Over seven years, 876 incident BPH cases were documented. When the investigators analyzed factors such as diet, alcohol, and supplement use via a food frequency questionnaire, they determined there were no associations between supplemental antioxidants and BPH risk, and there was “weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk.” (Kristal 2008)

      At least one study has reported that a low level of vitamin D circulating in the blood is linked to a greater risk of having an enlarged prostate or prostate cancer. An epidemiological study of 977 randomly chosen men investigated the prevalence of prostate disease based on blood samples, a questionnaire, and physical examination. Investigators found a 23.1 percent prevalence of BPH, 5.1 percent of prostatitis, and 3.7 percent of prostate cancer. Among other discoveries, the authors reported finding lower levels of vitamin D in men who had BPH and prostate cancer. Because vitamin D inhibits cellular proliferation, the authors noted that “lower levels are confirmatory with its loss of protective role against prostate cancer.” (Galic 2008)

      Additional evidence can be found in a study conducted in Italy in which researchers identified how the vitamin D receptor agonist elocalcitol, a synthetic derivative of vitamin D3, is capable of stopping growth of the prostate in men who have BPH. The process by which elocalcitol both stops inflammation and the growth of BPH cells is complex, and involves elocalcitol’s ability to significantly inhibit production of IL-8, a substance involved in BPH pathogenesis, by BPH cells stimulated with inflammatory cytokines, and IL-8-induced proliferation of BPH cells. The authors concluded that their data “provide a mechanistic explanation for the anti-proliferative and anti-inflammatory properties of elocalcitol in BPH cells. (Penna 2009)

  • Posted

    Interesting. I have been vitamin D deficient for many years although it apparently is quite common and my physician was never bothered by it
  • Posted

    Not that it is scientific, but I have been taking a Vitamin D supplement for at least 10 years in the winter. 1000 IU daily. I get plenty of sun in the other 6 months of the year.

    So, I don't think it worked in my case, I'm younger than most at 54. 

    • Posted

      1000IU may not be a therapeutic dose. For example, one study cited 6000IU/ day.
  • Posted

    I was diagnosed with BPH 4 years ago and am 54. Urologist noted weak stream whilst doing tests for something else and put me on Flomax for a short period. I also have Vit D deficiency and after taking tablets for a couple of years with no effect my GP suggested Sunshine Juice 2500mg Vit D. My Vit D went from 19 to 45 and I've been taking it ever since, though reduced dosage from daily to twice weekly. Vit D now normal. My BPH symptoms have improved somewhat in the past couple of years, weak stream got a bit better, night time urination back from 6-7 times to 1-2 and was able to stop taking Tolterodine too. I know my prostate is around 45-50cc but take no BPH MEPs now.

    • Posted

      I am in the sun all the time, and have a very large prostate.  Did turp twice and Greenlight laser once. I live in Hawaii, and so lots of sun,and I am always in the yard, and when I was younger, out surfing several times a week...and when I was really young, into my 40's, at the beach daily.

  • Posted

    I started taking 5000 units of Vit. D3 four years ago since I had low levels. Not sure it had any affect on my prostate, but did stop my sinus infections and related issues. I take it every other day now and my levels are still good. Also take liquid Vit. B complex. The B 12 part hellps with energy.
  • Posted

    I've seen this. I'm a little leery of this whole sudden vitamin D infatuation/marketing blitz...All of a sudden we're all deficient and it's a cure for what ails you... Not saying there's zero credibility... more investigation needed...It seems there's an association in the study between BPH and low D ..this is not proof.. It's like saying people who smoke eat red meat more than others... It doesnt mean one causes the other. It's just an association.

  • Posted

    You would think if this were true, there would be a correlation between geographic location and BPH. Less BPH suffering in sunny climates?
    • Posted

      Maybe so but every one seems to be covering up now due to skin cancer. A friend of mine started taking vitamin d for tendinitis. He claims it worked. He tried cortisone shots prior to that and only had temporary relief.
  • Posted

    Hello uncklefester and thanks for this post.

    I've been taking D3 for a few years now. i take 5000 IU daily and one D3+K2 pill daily. K2 is very important to take with D3. I take 200mcg of K2 and the combined pill has 1000 IU of D3. So I also take 4 pills of D3 itself (1000 IU) each). I read much of the research on D3 and it seems well established. The article you sight is a good one and there are many others like it.

    So has it helped my BPH? I don't know. Like most of these oral supplements not much gets to the intended target which is why injections are best into the prostate but forget that.

    Take care.

    Neil

  • Posted

    Hi unclelefester, This is a very interesting ,thanks for that info.I will increase my Vit D.

    I f i could find a way to have a NV without surgery this would be the best thing that evev happened to me. Thanks for this .

    frank

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