What are Symptoms of GCA in body other than head ?
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Can anyone tell me if there are any symptoms of GCA to look out for in the body ? I remember reading a post a little while ago that said to check pulses and blood pressures. Do blood vessels protrude in your body like they do in your temples ? I have a small protruding vein (artery?) in my lower abdomen which my doctor says is probably a varicose vein. I would be grateful for anyone else's experience on this please. Thank you.
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EileenH jan21306
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Until relatively recently it was only at autopsy that you could find artery walls that had the giant cells present - it is not possible to take a bit of these other arteries to examine except in a major operation. As a result it wasn't clear that many other arteries could be affected. In recent years imaging techniques have been developed so you can "see" which arteries are involved - PET-CT or PET-MRI are the best where a radioactive substance is injected and is taken up by the inflamed tissue and then shows up on the images. It is possible to see the brachial artery using ultrasound - that is the artery supplying the arms.
In PMR it is thought that the microcirculation is affected in some way - the very smallest blood vessels on the arterial side of the circulation so that the supply of oxygen to the muscles is reduced and the removal of waste products impeded. The details aren't yet clear but there is research being done at present.
What you can see on your abdomen is a vein - veins are never involved, they don't have an elastic part to the vessel wall. The same applies to the protruding vessels on the back of your hand - the artery is relatively deep in the wrist where your pulse can be felt and those on the back of the hand where they sometimes take blood or put a cannula in are veins.
The very high doses used for patients with visual symptoms are to reduce the swelling quickly to try to avoid loss of vision. You can't see how bad the blockage is so you have to go at it with a sledgehammer to crack the nut. Most experts feel that much lower doses will control the inflammation in other arteries - but the higher the dose the quicker it will be reduced. If vision is affected there isn't time to wait for a lower dose to work. Even in PMR it is known that a dose of 12.5mg is enough to get a result in 75% of patients within a month - 15mg does it quicker!
It is becoming clear that it is fairly likely that much of the severe arm and leg stiffness in PMR is really due to GCA - and it is in these patients that PMR happens before they develop any visual symptoms. Some people only ever show PMR symptoms, some people only show GCA symptoms affecting the arteries in the head - and some have a bit of both. However, it is not true to say that because you are on a low dose of pred you cannot develop temporal arteritis or cranial GCA. It all depends on how severe it is.
VickieS EileenH
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jan21306 EileenH
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EileenH jan21306
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jan21306 EileenH
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penelope10875 EileenH
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VickieS EileenH
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Emis Moderator comment: I have added a link to the article below.
http://www.eurekalert.org/pub_releases/2014-06/elar-cum061114.php
EileenH penelope10875
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ptolemy VickieS
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tina-uk_cwall VickieS
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EileenH ptolemy
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EileenH VickieS
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EileenH tina-uk_cwall
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And the noble Lord Turnberg - a medical doctor - in taking up his place to speak and thanking Lord Wills spoke of giant cell ARTHRITIS. Now I know patients confuse athritis and arteritis - but heaven help us when a medically qualified personage gets them confused.
tina-uk_cwall EileenH
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VickieS
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