What are ther effects of using Asacol (Masalazine)400 mg MR tablets on liver

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I am a male aged almost 26 years old,  I have been in remision with Ulcerative Colitis since I was aged 19, the medication I am on is Asacol (Masalazine)400 mg MR tablets which I take 6x daily.  

I have been in great health without problems since using thse tablets and now almost 7 years on I have now found out that they harm the liver and some people in rare cases have suffered liver damage.

I do not drink alchohol, smoke or take take drugs (only prescribed Mesalazine).

I had always thought that my liver may be in good condition however I have read that the liver function tests carried out Asacol users taking the same dosage as me found that the tablets have the same effect as what moderate drinking would have on the liver.

AST/ALT levels in the bloodstream are elevated when using these tablets.

The reason I don't drink alchohol is to not damage my liver yet these drugs could be doing the same damage as alchohol.

Is this true?

Does anybody ese not drink alchohol on this forum or do you know about the risks of Asacol on the liver.

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5 Replies

  • Posted

    Hi d123 Ihave been on 4 tablets a day now fer 4 weeks and also an enama every night. Do you also have enamas as well as taking the tablets.I didnt know you had to keep taking the tablets .Ithought it was all finished after a month on them. and i would be better. that is what the doctor told me. Babz.


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  • Posted

     What plus the enamas.Dread to think !!!!


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  • Posted

    done my full month now . and it's come back worse than ever.Doctor said if I do this I will be back to normal .What a lie !!!! 


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  • Posted

    I didn't have to do enamas/enaemas but yeah, the tablets are okay as long as you take them at some point during the day.  It can be a lot worse for other people with ulcerative coltis but now I forget I evenhave to take tablets for my condition.  I know how you feel, I can remember lying in hospitial worrying about what was happening when I first got UC, but I think they will get you well enough eventually.
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