Which are the substances(ingestible) which make a person extremely weak?

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Which are the substances(ingestible) which make a person extremely weak? These types of persons are extremely calm; do not stand, walk too much, keep on sitting. The body gets permanently very weak. Now, ... the nerves are the part of the body, so they also get weak automatically. The person does not have the vigour, nor he has a wish to fight with anyone. Actually, he does not interact with anyone, always remain non-enthusiastic. It's the drastic physical and hence, the nervine weakness.

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