Withdrawal?? 4 wks of Mirtazapine - now switching to Vortioxetine (Trintellix)

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Hi everyone,

I need your experiences with switching from Mirt to another Antidepressant/Antipsychotic please.

I have been taking Mirtazapine 15 mg at night for 4 weeks. Because of the weight gain issue I have asked for a replacement and after seeing a specialist yesterday I will be starting Vortioxetine (Trintellix) this week.

The two medications are very similar in chemical structure, medical effect etc. and I am wondering if I have to wean off Mirtazapine or if I can just switch from one to the other.

According to the product description the withdrawal symptoms of Trintellix seem to be the same as those of Mirtazapine:

"Stopping this medication suddenly may lead to side effects such as dizziness, abnormal dreams, numbness or tingling sensations, agitation, anxiety, nausea, vomiting, sweating, or other symptoms."

That's why I am thinking that a switch should have no major side effects since both drugs are of the same "family".

Vortioxetine (Trintellix) is a fairly new drug that has just been approved last year here in Canada for distribution, so I don't expect anyone to have experience with exactly this combination, but maybe you have been switched to Lithium or some other AD/AP.

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  • Posted

    This is something you need to discuss with your doctor or someone who actually understands these drugs. No way can we advise you to stop one and start another.

    I wish you luck....confused

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  • Posted

    hi mermaid,

    i guess you are in canada too?  i don't know the anser to your question i'm afrai.  were you put on mirtzapine for sleep?  initially i was but then it wasincreased fro it's antidepressant effect .. and it has been difficult.  i would definitely ask the dr. if u can.  i guess we get more ansers from this website sometimes than we do from the drs

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    • Posted

      Yes I am! You are too? I am in Toronto.

      And yup... I find the best answers here in the forum and by researching on my own. My dr is nice but it's obvious that psychiatrists know more about the chemical components of a drug than about the "real life experience". smile

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    • Posted

      i actually went down to camh (emergncy) just so i could see a psychiatrist.  mind you it's still trial and error .  but i am going to do a test that is supposed to help determine dosages and medication, as🎒i have been having a really hard time.  i have to sleep with a sleeping pill ... and the mirtz at 30mg was giving me anxiety, so doc said to reduce .. then i wasextra sad.. so i am back on 30.
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    • Posted

      Good for you! CAMH is the place to go! Trial and Error... tell me about it... I've been going through different meds for 5 months now. I hope this one will be "the one".... smile
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