Worms in the Face

https://en.m.wikipedia.org/wiki/Enzyme_catalysis

Systematic computer simulation studies established that electrostatic effects give, by far, the largest contribution to catalysis.[10] In particular, it has been found that enzyme provides an environment which is more polar than water, and that the ionic transition states are stabilized by fixed dipoles. This is very different from transition state stabilization in water, where the water molecules must pay with "reorganization energy".[12] In order to stabilize ionic and charged states. Thus, the catalysis is associated with the fact that the enzyme polar groups are preorganized [13]

The magnitude of the electrostatic field exerted by an enzyme's active site has been shown to be highly correlated with the enzyme's catalytic rate enhancement[14][15]

Binding of substrate usually excludes water from the active site, thereby lowering the local dielectric constant to that of an organic solvent. This strengthens the electrostatic interactions between the charged/polar substrates and the active sites. In addition, studies have shown that the charge distributions about the active sites are arranged so as to stabilize the transition states of the catalyzed reactions

Covalent catalysis involves the substrate forming a transient covalent bond with residues in the enzyme active site or with a cofactor. This adds an additional covalent intermediate to the reaction, and helps to reduce the energy of later transition states of the reaction. The covalent bond must, at a later stage in the reaction, be broken to regenerate the enzyme. This mechanism is utilised by the catalytic triad of enzymes such as proteases like chymotrypsin and trypsin, where an acyl-enzyme intermediate is formed. An alternative mechanism is schiff base formation using the free amine from a lysine residue, as seen in the enzyme aldolase during glycolysis.

Some enzymes utilize non-amino acid cofactors such as pyridoxal phosphate (PLP) or thiamine pyrophosphate (TPP) to form covalent intermediates with reactant molecules.[16][17] Such covalent intermediates function to reduce the energy of later transition states, similar to how covalent intermediates formed with active site amino acid residues allow stabilization, but the capabilities of cofactors allow enzymes to carryout reactions that amino acid side residues alone could not. Enzymes utilizing such cofactors include the PLP-dependent enzyme aspartate transaminase and the TPP-dependent enzyme pyruvate dehydrogenase.[18][19]

Rather than lowering the activation energy for a reaction pathway, covalent catalysis provides an alternative pathway for the reaction (via to the covalent intermediate) and so is distinct from true catalysis.[10] For example, the energetics of the covalent bond to the serine molecule in chymotrypsin should be compared to the well-understood covalent bond to the nucleophile in the uncatalyzed solution reaction. A true proposal of a covalent catalysis (where the barrier is lower than the corresponding barrier in solution) would require, for example, a partial covalent bond to the transition state by an enzyme group (e.g., a very strong hydrogen bond), and such effects do not contribute significantly to catalysis.

Diffuse Cutaneous Leishmaniasis

This very rare form is characterized by an initial skin lesion that spreads to affect the skin of multiple different areas of the body. Individuals often have a poorly functioning immune system, which leaves them susceptible to widespread involvement of the skin, predisposes to a poor response to treatment and permits infection to last indefinitely. Affected individuals may have multiple plaques, ulcers and nodules all over their body. Diffuse cutaneous leishmaniasis progresses slowly, but is a chronic condition that routinely recurs after treatment even if treatment appears to have been initially effective.

Leishmaniasis Recidivans

This term is used to define the recurrence of a skin lesion years after the initial lesion healed. Leishmaniasis recidivans often develops on the face, particularly the cheek, with a new ulcer or papule forming over or near the scar of the old lesion. Sometimes this lesion may slowly grow larger.

MUCOSAL LEISHMANIASIS

Parasites can spread from the initial skin lesion via the bloodstream to other distant sites such as the mucous membranes of the nose, mouth and throat. Individuals with mucosal leishmaniasis typically have had a skin lesion that healed on its own or with treatment, only to develop mucous membrane involvement often several years or sometimes decades later. Persistent stuffiness in or bleeding from the nose may be the first signs of the disease. Inflammation and partial to total destruction of the mucous membranes of the mouth, nose and throat can eventually occur. If untreated, mucosal leishmaniasis can cause disfiguring damage and scarring to the nose and mouth. Nasal obstruction and bleeding may result from this damage. Complications can be difficult to treat and progressively worsen. Mucosal leishmaniasis can develop in people who were not treated or were originally inadequately treated for cutaneous leishmaniasis. Known risk factors for the development of mucosal disease include: infection with particular parasite species often found in South America; skin lesions which are multiple, large, long-lasting or on the head or neck; a suppressed immune system; or infection acquired in Bolivia...

I normally have an exceptional immune system... but I was actively participating in a religious practice where I witheld eating.. this would suppress my immune system.

i have the same exact symptom that you are and they are also in my legs and chest and arms i have a oil like liquid that penetrates from my skin when I'm in the shower and i can push down on my legs and seems neck face everywhere it literally drips out.i gained about 10 pounds all of a sudden in my gut area.i don't know exactly Howe long ice had this but a while.please keep me informed on what your specialist says

a lot of well known and popular internet stores have microscopes for $20 . they have slides and pipettes (are important so I've learned)

hello do you have pictures etc cause i think i have them ive noticed it more in the last 2-3 years sometimes wearing yoga pants feels like something caught my pants and now im itchy an now on my chin i had a zit but then i got all shiney when broke it open and i pulled a zit out anf it bled and then looked again their was three more then used peroxide an holy hell that stung then woke sore AND more sores that looks like zits and on my lips its a white piece looks like dead skin.peel it off then its back can i get info how to tell the doc etc i live in canada b.c email is ckuch619@gmail.com