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The lower denture of my mother aged 79 years does not fit properly because of gum recession. The maxillofacial surgeon in India recommended her denture implantation. But when I told the doctor that she has taken the 3rd injection of Stoplos One (zoledronic acid) in India on 28.09.2019 and the 1st injection of Olimab (Denosumab) on 01.03.2020, he refused to do the denture implantation as he said it will lead to osteo-necrosis of the jaw or any other serious damage to the bone.
My mother’s recent Bone Mineral Density Test done on 23.02.2020 shows the following:
Site Region T-Score BMD
Left forearm Radius 33% -4.9 0.450g/cm2
Right forearm Radius 33% -3.5 0.573g/cm2
Dual Femur Neck Left -1.7 0.797g/cm2
Dual Femur Neck Right -1.9 0.780g/cm2
AP Spine L1 - L4 -1.4 1.006 g/cm2
The orthopedic doctor has prescribed Olimab S.C. 60 mg injection (Denosumab) found in India . He also prescribed to continue Stoplos One (Zoledronic acid) for 2 more years. My mother has already taken Bonmax Pth (teriparatide) injection for 2 years from October 2015 to September 2017 and Stoplos One (zoledronic acid) for 3 years from October 2017 to October 2019.
I want to know now whether Bisphosphonates like zoledronic acid increases the risk of fractures, irregular heart beat and osteonecrosis of the jaw. Does zoledronic acid suppress bone remodeling which is supposed to stop bone loss. Does low bone density increases the risk of fractures or it is not? A YouTube video on “The end of Osteoporosis” says that Bone Mineral Density is not a good predictor for fractures. Bone density does not equal bone quality. According to the video low bone density does not increase the risk of fractures. Osteoporotic fractures may happen to persons having good bone mineral density.
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