Zoloft lamictal wellbutrin not working anymore

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I will try to keep this short.  I’ve been on these for years.  Some generics don’t work.  Increasing Zoloft causes hair pulling (weird I know). Lately I am noticing that an hour or so after taking them I seem to be more depressed and have obsessive negative thinking/ worrying.  Nothing has changed in my life.  I’m not sure if something is finally pooping out after so many years (20 on the Z). WB and L about 10.  Should I be looking to try something different ?  Or maybe try taking at night instead of morning?  Any ideas?  Thanks

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  • Posted

    You have been on your medications for twenty years.

    You could try taking your medications about one hour before bed. However is you feel a return of negative thoughts it may be a chat with your GP may help.

    Your Doctor needs to discuss your problems and consider if a change in medications will hel


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  • Posted

    Hello 2chr,

    It's entirely possible that your medication dosage has 'pooped out' after that long. I have been on Paxil for over 25 years, since I was diagnosed with clinical depression at age 38. Recently, I've been through some family deaths and related legal issues and I noticed my medication was not handling this stress as well as it used to-my Psychiatrist upped the dose from 20 mg/day to 30 mg/day to handle this.

    It seems to be working better now, the problems are manageable at any rate. You should talk to your Psychiatrist or GP and see if an adjustment is needed. Increased dosage or even a new medication. Worked for me.

    I wish you the best of luck!

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