- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
(21751) First-in-human single dose escalation study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of BAY 3018250 in healthy men in a randomized, placebo-controlled, single-blind, group-comparison design
This early-stage study is looking at a new medicine called BAY 3018250 for treating strokes. It's the very first time this medicine is being given to people. We want to check if it's safe and how the body handles it in healthy men.
Germany - authorisedTherapeutic confirmatory (Phase III)
TENACITY – A Phase III, prospective, randomized, open-label, blinded endpoint assessment (PROBE) to assess efficacy and safety of i.v. tenecteplase vs standard of care in patients with acute ischemic stroke (including wake-up stroke), last known well >4.5 h with imaging evidence of salvageable ischemic tissue
This study is looking at a new way to treat people who have had a stroke caused by a blood clot. It compares a drug called tenecteplase with the usual care, especially for those treated later or who wake up with stroke symptoms.
Greece · Norway · Hungary - authorisedTherapeutic confirmatory (Phase III)
Sevoflurane vs. propofol for general Anesthesia in patients with acute ischemic stroke treated with endoVascular treatmEnt (SAVE trial)
This study compares two common anaesthetics, sevoflurane and propofol, for patients having a procedure for a severe type of stroke. Researchers want to see if one anaesthetic helps reduce the amount of brain damage after the procedure.
Spain - recruitingPHASE2
A Study of TAK-755 in Adults With Acute Ischemic Stroke
This study is testing a new medicine, TAK-755, for adults who have had a sudden stroke (acute ischemic stroke). It aims to see how safe TAK-755 is, how well people tolerate it, and if it helps them recover compared to a dummy medicine. All participants also receive standard stroke care.
United States · Belgium · Brazil - recruiting
Plaque Imaging in Routine Care to Detect Intraplaque Hemorrhage
This study looks at whether a specific type of MRI scan of a neck artery can help doctors understand why someone had a stroke. It focuses on finding small bleeds within the artery wall to see if they are linked to strokes.
Germany - recruitingNA
Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion (ETICA)
This study looks at a new way to treat severe strokes caused by a blocked neck artery. It compares a special procedure (EVT) plus standard care to standard care alone, to see if the procedure helps people recover better.
France - recruitingPHASE3
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study looks at treating an irregular heartbeat called atrial fibrillation (AF) early after a stroke. We want to see if quick treatment of AF can stop future strokes and other heart problems better than the usual care.
Germany - recruitingNA
Safety and Efficacy Evaluation of the Ceretrieve Device in the Treatment of AIS Patients
This study is testing a new device, Ceretrieve, to treat strokes caused by a blood clot. Researchers want to see if it's safe and works as well as existing treatments to unblock blood vessels in the brain, helping patients recover after a stroke.
Germany - active not recruitingNA
Permanent Intracranial Stenting for Acute Ischemic Stroke Related to a Refractory Large Vessel Occlusion
This study looks at a new way to treat severe strokes where initial clot removal didn't work. It investigates whether placing a small, permanent support (stent) in the brain's blood vessels, along with standard care, is better than standard care alone.
France - authorisedHuman Pharmacology (Phase I)- First administration to humans
A randomized, placebo-controlled, double-blind, single-ascending-dose, Phase 1a/b study to assess the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of intravenous NTR-641 in healthy adults and patients with acute ischemic stroke
This study is testing a new medicine called NTR-641 for people who have recently had a stroke caused by a blood clot. We want to see if it's safe, how it works in the body, and if it causes an immune reaction, starting with healthy volunteers.
Austria - recruitingPHASE3
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
This study is testing a new drug called sovateltide for people who have had an acute ischemic stroke. Researchers want to see if it's safe and helps improve recovery, building on promising results from earlier studies using normal saline as a comparison.
United States · Germany · Spain - recruiting
German Stroke Registry - Endovascular Treatment
This study looks at how well a treatment for stroke works in Germany. Doctors collect information from patients who have a blocked blood vessel in their brain. The aim is to learn more about how this treatment helps people recover after a stroke.
Germany - recruitingNA
Safety and Efficacy Evaluation of the iNstroke 4F Thromboaspiration Catheter in Patients With Acute Ischaemic Stroke Due to Primary Distal Medium Vessel Occlusions (DMVO)
This study looks at a new device called the iNstroke 4F catheter. It's for people who have had a specific type of stroke where small blood vessels in the brain are blocked. We want to see how safe and effective this device is at clearing these blockages.
Germany · Hungary · Spain - ongoing, recruitingTherapeutic use (Phase IV)
Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment
This study is looking at two different medicines after treatment for a severe type of stroke. It compares a blood-thinning medicine called Tirofiban with aspirin to see which is safer and works better to prevent more problems after the stroke treatment.
Spain - ongoing, recruitingPhase II and Phase III (Integrated)
GREEN A randomized, double-blind, multi-center, placebo-controlled, efficacity and safety study of glenzocimab used as an add-on therapy on top of mechanical thrombectomy for acute ischemic stroke
This study, called GREEN, is testing a new drug called glenzocimab for people who have had a stroke. It wants to see if adding glenzocimab to standard treatment helps patients recover better and quickly after their stroke. The study is checking how well it works and if it's safe.
France - authorisedTherapeutic confirmatory (Phase III)
MidregiOnal proatrial natriuretic peptide to guide SEcondary Stroke prevention: The MOSES-study. An international, multicentre, randomised-controlled, two-arm, assessor-blinded trial.
This study, called MOSES, is looking at how best to prevent another stroke in people who have recently had one. It's testing if a specific blood test, together with different blood-thinning medicines, can help doctors choose the best treatment to stop future strokes.
Greece · Spain - authorisedTherapeutic exploratory (Phase II)
A randomized placebo-controlled double-blind trial phase II two-arm study to investigate infarct growth over 72 hours assessed with diffusion weighted imaging on MRI after treatment with intravenous tocilizumab or placebo in patients above 18 years of age with acute ischemic stroke undergoing endovascular thrombectomy.
This study looks at a new treatment called tocilizumab for people who have had a severe stroke. Researchers want to see if this medicine can help limit the size of the stroke damage in the brain. It's compared to a dummy treatment to see if it works.
Norway - active not recruitingNA
EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial)
This study looks at a procedure called thrombectomy for strokes caused by clots in medium-sized brain blood vessels. It compares this procedure plus standard care to standard care alone, to see if it improves recovery for patients in the UK.
United States · Canada · Germany - ongoing, recruitingTherapeutic use (Phase IV)
A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)
This study looks at different ways to control blood pressure in people who have had a stroke and treatment to unblock a brain blood vessel. Researchers want to find the best approach to help patients recover well, focusing on how their brain receives blood after treatment.
Spain - active not recruitingPHASE2
A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke
This study is looking at a new medicine called Redasemtide for people who have recently had a stroke. It wants to see if the medicine is safe and if it helps people get better after a stroke.
United States · Australia · Belgium - active not recruitingNA
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke
This study compares a special clot-removing procedure (endovascular therapy) plus standard care against standard care alone for people who have a stroke caused by a blockage in a medium-sized brain blood vessel. It aims to see if the procedure reduces long-term disability.
Belgium · Finland · Germany