- recruitingPHASE1
A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy
This study is looking for the best way to give a new cancer drug, rilvegostomig, as an injection under the skin instead of through a vein. It's for adults with advanced solid cancers who have already had standard treatments.
United States · South Korea · Spain - active not recruitingPHASE1, PHASE2
A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
This study looks at new drug combinations for advanced cancers. We want to see if they're safe, how well they work, and what effects they have on the body. It involves different stages to find the best doses and see benefits.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase IB Study to Assess the Safety, Tolerability and Efficacy of PM14 in combination with Atezolizumab in Pretreated Patients with Selected Advanced Solid Tumors
This study is testing a new combination of two medicines, PM14 and atezolizumab, for people with advanced cancers that have already been treated. Doctors want to see if it's safe, how well people tolerate it, and if it helps treat these cancers.
Spain - active not recruitingPHASE1, PHASE2
A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors
This study is testing a new medicine, ZN-A-1041, for people with advanced cancers that have a specific marker called HER2. It will look at how safe and effective ZN-A-1041 is, both alone and with other usual treatments, for solid tumours including breast cancer.
United States · Australia · France - active not recruitingPHASE1
A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors
This study is testing a new drug, BAY2965501, for advanced cancers like skin, kidney, stomach, and lung cancer. It aims to find a safe dose, how it affects the body, and if it helps shrink tumors. The drug works by boosting the body's own immune cells to fight cancer.
United States · Belgium · China - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti_Tumor Activity of AVZO-021 as a Single Agent and in Combination Therapy in Patients with Advanced Solid Tumors.
This study is testing a new drug, AVZO-021, for people with advanced cancers. It's the first time it’s being given to humans, looking at how safe it is, how the body handles it, and if it can help fight the cancer.
Belgium · Spain · Italy - recruitingPHASE1, PHASE2
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
This study looks at a new drug, mRNA-4359, by itself and with other cancer drugs. It aims to see if it's safe and what side effects it might have in people with advanced solid tumours, which are cancers that have spread.
United States · Australia · Italy - recruitingPHASE1, PHASE2
TT-702 in Patients With Advanced Solid Tumours.
This study is testing a new drug, TT-702, for people with advanced cancers. We want to find a safe dose of TT-702, by itself and with another drug called darolutamide, and see how it affects tumours.
United Kingdom - authorisedHuman Pharmacology (Phase I)- First administration to humans
Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
This study is testing a new medicine called M7437 for people with advanced cancers that have spread. It's the very first time this medicine is being given to humans, to see if it's safe and how it works in the body. The aim is to find new ways to treat these difficult cancers.
Spain - active not recruitingPHASE1
A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors
This study is testing a new drug, BAY3375968, alone or with pembrolizumab, for advanced solid tumours. It aims to find a safe dose and understand how it works by boosting the immune system to fight cancer.
United States · Belgium · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Multicenter, Open-Label, Phase I/II Study of EOS884448 in combination with standard of care and/or investigational therapies in participants with advanced solid tumors
This study is testing new combinations of medicines for advanced solid cancers. It looks at how safe the treatments are and how well they shrink or control the cancer. The aim is to find better ways to treat these cancers.
Italy · France · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumors
This study is testing a new medicine called RP3, sometimes with another medicine called Nivolumab, for people with advanced cancers. It's the very first time these treatments are being given to humans, to see how safe they are and what effects they have.
Spain · France · Greece - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of MK-0482 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-0482-001)
This study is looking at a new medicine, MK-0482, for people with advanced cancer. It will be tested alone and with another common cancer drug, pembrolizumab. The goal is to see if these treatments are safe and how they work in the human body. This is a very early stage of research.
Spain · Italy - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2 Study of BMS-986253 in Combination with Nivolumab or Nivolumab plus Ipilimumab in Advanced Cancers
This study is testing a new medicine, BMS-986253, alongside existing cancer treatments (Nivolumab and Ipilimumab) for advanced cancers. Doctors want to see how safe the combined medicines are and if they help shrink tumors. It's an early-stage study to gather important information.
Italy · Germany · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Study of safety and antitumor activity of GEN1056 in participants with advanced solid tumors
This study is testing a new medicine called GEN1056 for people with advanced cancers that have spread. It's the first time this medicine is being given to humans, to see if it's safe and if it can help fight cancer. All adults aged 18 and over can take part.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study of HFB200603 as a single agent and in combination with Tislelizumab in patients with advanced solid tumors
This study is testing a new medicine called HFB200603, both on its own and with another medicine called Tislelizumab. It's for adults with advanced solid cancers. This is a very early study, to see how safe the medicine is and what effects it has on the body.
Italy · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to find a suitable dose of BI 1821736 and test whether it helps people with advanced cancer
This study is looking for the right dose of a new medicine, BI 1821736, for people with advanced cancers that have spread. It also wants to see if this medicine can help treat these cancers.
Sweden · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of ZL-1218 with or without Pembrolizumab in Subjects with Advanced Solid Tumor Cancers to Find a Suitable Dose and to Test How Different Doses of these Medications can be Tolerated by the Body
This study is testing a new medicine, ZL-1218, sometimes given with another drug called pembrolizumab, for people with advanced cancers. Doctors want to find a safe dose and see how well people tolerate it, as this is the first time these drugs are being used in humans.
Spain - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
An Open Label, Phase 1/2 Study of HST-1011 Given as Monotherapy and in Combination with an Anti-PD1 Antibody in Patients with Advanced Solid Tumors
This study is testing a new medicine called HST-1011, by itself and with another medicine called Libtayo, for people with advanced cancers. Researchers want to see if these treatments are safe, how they work in the body, and if they help shrink tumors.
Spain - authorisedHuman Pharmacology (Phase I)- First administration to humans
A Study Testing the Investigational Drug XmAb541 in people with Advanced Cancer
This study is testing a new medicine called XmAb541 for people with advanced cancer. It's an early-stage study to see how the medicine works in people for the first time, checking its safety and effects.
Spain · France · Belgium - recruitingPHASE1, PHASE2
Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.
This study is testing a new medicine, WEF-001, for people with advanced cancers that have a specific genetic change called a 'KRAS mutation'. Doctors want to see if it's safe, how the body handles it, and if it could help shrink tumours.
United States · Canada · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 as Monotherapy in Patients with Selected Advanced Solid Tumors
This study is testing a new medicine, ADCT-901, for people with advanced cancers that have spread. It's the first time this medicine is being given to humans, to see how safe it is, what side effects it has, and if it helps shrink tumours.
Spain - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First in-Human, Consecutive-Cohort, Clinical Trial of BI 1910, a Monoclonal Antibody to Tumor Necrosis Factor Receptor 2 (TNFR2), as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
This study is testing a new drug, BI 1910, for people with advanced cancers. It will check how safe the drug is, what side effects it causes, and how much of it the body can handle, both on its own and when given with another cancer drug.
Denmark · Poland · Spain - recruitingPHASE1
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
This study is testing a new medicine, INCA33890, for people with advanced or spreading solid cancers. Doctors want to see how safe the medicine is, what side effects it causes, and find the best dose to give.
United States · Denmark · France - authorisedPhase I and Phase II (Integrated)- Other
C6461020 - An Interventional Open-Label Phase 1b/2 Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of PF-08634404 in combination with Different Anticancer Agents in Participants with Advanced Solid Tumors
This study is testing a new combination of treatments, including a medicine called PF-08634404, for people with advanced solid tumours. It aims to see how safe the treatments are and how well they work together against cancer.
Italy · Spain · France - not yet recruitingPHASE1, PHASE2
A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors
This study is testing a new drug, LCB02A, for people with advanced cancers that haven't responded to usual treatments. It aims to find the right dose and see if it helps shrink tumors by targeting a specific protein called Claudin 18.2.
United States · Canada · South Korea - active not recruitingPHASE1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
This study looks at a new drug, ABBV-400, for advanced cancers like lung and bowel cancer. We're checking how safe it is and if it helps shrink tumours, both on its own and with another drug.
United States · Australia · France - active not recruitingPHASE1, PHASE2
A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors
This study is looking at a new drug, BMS-986449, by itself and with another drug, nivolumab, for people with advanced cancers. Researchers want to see if these treatments are safe and effective. It's for patients whose cancer hasn't responded to usual treatments.
United States · Belgium · France - active not recruitingPHASE1
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
This study is looking into new ways to treat advanced cancers that have a specific genetic change called KRAS p.G12C. It's testing a drug called sotorasib, either by itself or with other treatments, to see how safe and effective they are for adults.
United States · Australia · Austria - recruitingPHASE2
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation
This study looks at continuing treatment with sotorasib, sometimes with a drug called panitumumab, for people with advanced cancers that have a specific genetic change (KRAS p.G12C). It checks how safe the treatments are and if they're well-tolerated.
United States · Australia · France - recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
This study is testing a new drug, VVD-133214, for advanced solid tumours, including a type of bowel cancer. It looks at safety, how the body handles the drug, and if it can help shrink tumours. It's an early-stage study, sometimes testing the new drug with other standard treatments.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
Study of DT-7012 as a Single Agent and in Combination With an Immune Checkpoint Inhibitor in Participants With Advanced Solid Tumors
This study is testing a new drug, DT-7012, both on its own and with another cancer drug, for people with advanced solid tumours. It aims to see if it's safe, what dose works best, and how well it treats the cancer. This is an early-stage study.
United States · Australia · France - recruitingPHASE1
An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
This study is testing a new cancer medicine, TEV-56278, on its own and with another medicine called pembrolizumab, for people with advanced solid tumours. Researchers want to see if it's safe, what dose works best, and if it can shrink tumours.
United States · Canada - recruitingPhase I
A first-in-human, phase 1/2, multicenter, open-label, dose escalation, confirmation and expansion study to evaluate the safety, pharmacokinetics and antitumor activity of TH9619 in subjects with advanced solid tumors (ODIN)
This study is testing a new drug, TH9619, for people with advanced cancer. It's the first time it’s being given to humans, aiming to see if it’s safe, how it works in the body, and if it can help fight cancer.
United Kingdom · France · Spain - active not recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
This study is testing a new medicine, GDC-6036, for people with advanced cancers that have a specific genetic change called KRAS G12C. It will look at how safe the medicine is and if it helps shrink tumors, sometimes combined with other treatments.
United States · Australia · Belgium - recruitingPHASE1
A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)
This study is testing a new drug called Calderasib, alone or with other treatments, for advanced cancers with a specific gene change (KRAS G12C). It's looking at how safe and effective these treatments are.
United States · Argentina · Australia - recruitingPHASE1
Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)
This study looks at a new treatment called MK-0472 for advanced or spreading cancers. It's given alone or with other medicines like pembrolizumab or MK-1084 to see how well it works and if it's safe.
United States · Canada · Chile - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, First-In-Human, Multi-Part, Open Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF6002 as a Monotherapy and in Combination with Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion in Selected Indications
This study is testing a new drug (DF6002) for advanced cancers, alone or with an existing drug (Nivolumab). It's looking to see if it's safe, how it moves through the body, and if it helps shrink tumors. It's an early-stage trial for people with solid tumors.
France · Spain - recruitingPHASE1
Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
This study is testing a new medicine, TYRA-430, for people with advanced liver cancer or other advanced solid tumours that have specific gene changes. Researchers want to see if it's safe and if it can help shrink tumours.
United States · Canada · South Korea - recruitingPHASE1, PHASE2
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
This study looks at a new drug, Marlotamig, by itself and with other treatments for advanced cancers. We want to see if it's safe, how well it works, and find the best dose to help shrink tumours.
United States · France · Israel - recruitingPHASE1, PHASE2
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
This study is testing a new drug called TUB-030 for adults with advanced solid cancers. Researchers want to see if it's safe, how well it works, and find the right dose. It's a first step to understand if TUB-030 could be a future treatment.
United States · Canada · Romania - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of Mipasetamab Uzoptirine (ADCT-601) Monotherapy and in Combination with Other Anti-Cancer Therapies in Patients with Selected Advanced Solid Tumors
This early-stage study is testing a new medicine called mipasetamab uzoptirine for people with advanced solid tumours. Researchers want to see if it's safe, how much can be given, and if it helps fight cancer, either alone or with other treatments.
France · Spain - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2a, First in Human, Open-Label, Multicenter, Dose Escalation Study with Expansion Cohorts to Evaluate the Safety, Tolerability, and Preliminary Activity of LB101 in Subjects with Advanced Solid Tumors
This study is testing a new medicine, LB101, for people with advanced cancers that have spread. Researchers want to see if it's safe, how much can be given, and if it helps to slow or stop cancer growth. It's an early-stage study.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1 Randomized Study to Evaluate the Effect of Food on the Bioavailability of BMS-986158 in Participants with Advanced Solid Tumors.
This study is looking at a new medicine called BMS-986158 for people with advanced cancers. Researchers want to see if eating food at the same time changes how well the body takes in the medicine. It's an early-stage study to understand the medicine better.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Tuvusertib (M1774) Human Mass Balance and Absolute Bioavailability Study (DDRIVER Solid Tumors 303)
This study looks at a new medicine called Tuvusertib for people with advanced solid tumours. It aims to understand how the body uses and gets rid of the medicine, and how much of it reaches the bloodstream when taken by mouth compared to other ways. This is an early-stage study.
Hungary - ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicenter, Open-label, Phase 2 Basket Study of MK‑7684A, a Co formation of Vibostolimab (MK‑7684) With Pembrolizumab (MK‑3475), With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (KEYVIBE 005)
This study, called KEYVIBE 005, is testing a new combination of medicines (MK-7684A, which includes vibostolimab and pembrolizumab) for people with advanced solid tumours. Researchers want to see how well this new treatment shrinks tumours and stops them from growing, either alone or with other cancer therapies.
Spain · Italy · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
This study is testing a new medicine, HFB200301, for adults with advanced cancers. It will check if the medicine is safe and how it works, both on its own and with another cancer drug called Tislelizumab.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1/1b Multiple-Ascending Dose Study of DF6215 in Patients With Advanced Solid Tumors
This early-stage study is looking at a new medicine called DF6215 for people with advanced cancers that have spread. Researchers want to find a safe dose and see how it works in the body.
France - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase I dose finding study of oral TNO155 in adult patients with advanced solid tumors
This study is looking into a new medication called TNO155 for adults who have advanced solid cancers that have spread. It’s a very early-stage study to find the best dose and check its safety. We want to see how the body handles this new medicine.
Netherlands · Italy · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A First-in-human study to learn how safe the study drug BAY2965501 is, find the best dose (single drug & combination), how it affects the body, what maximum amount can be given, how it moves into, through and out of the body, how it acts on different tumors in participants with advanced solid tumors
This study is the first time a new medicine, BAY2965501, is being tested in people. It aims to find out if it's safe, what dose works best, and how it affects the body in people with advanced solid cancers.
Belgium · Spain