- recruitingPhase I and Phase II (Integrated)- Other
Can a one-off administration of psilocybin reduce alcohol intake in patients with alcohol use disorder? A randomized, double-blinded, placebo-controlled clinical trial.
This clinical trial investigates whether a single dose of psilocybin, a compound found in magic mushrooms, can help adults cut down on heavy drinking. Researchers are comparing psilocybin capsules against a dummy treatment (placebo) to see if it reduces alcohol cravings and drinking days over a four-week period.
Denmark - recruitingPHASE3
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
This study is looking at a new medicine called brenipatide for people with moderate to severe alcohol use disorder. It compares brenipatide to a dummy medicine (placebo) to see if it's safe and effective in helping people cut down or stop drinking.
United States · Belgium · China - recruitingPHASE3
A Study of Brenipatide in Participants With Alcohol Use Disorder
This study is looking into a new medication called brenipatide for people with alcohol use disorder. It aims to see if it's safe and helps people reduce or stop their drinking, compared to a dummy treatment.
United States · Belgium · China - recruitingTherapeutic exploratory (Phase II)
Does the Glucagon-like Peptide 1 (GLP-1) receptor agonist semaglutide reduce alcohol intake in patients with Alcohol Use Disorder and comorbid obesity?
This study is looking into whether a medicine called semaglutide, which is usually for diabetes and weight loss, can help people with alcohol use disorder who also have obesity to drink less alcohol. It's an early-stage study to see if it works.
Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase 1, open-label, cross-over study in healthy volunteers to assess the pharmacokinetic profile of Prazosin and Cyproheptadine following single dose oral administration of KT110 tablet and following administration of Alpress and Periactine marketed tablets
This early-stage study is looking at how two existing medicines, Prazosin and Cyproheptadine, act in the body when given together in a new tablet called KT110. It involves healthy adults and aims to understand how much medicine gets into the blood and how long it stays there.
France - completed
Decision-making in alcohol use disorder
This study from the University of Sheffield is looking at how people make decisions about alcohol. It compares people with alcohol problems, those in recovery, and social drinkers to understand how their choices differ. The aim is to help improve treatments for people who want to drink less.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
Psilocybin in alcohol use disorder with comorbid depression - Randomized double-blind controlled pilot study.
This study is looking into whether psilocybin, a substance from certain mushrooms, might help people who have both alcohol use disorder and depression. It's a small, early-stage study to see if it's practical to give this treatment.
France - recruitingNA
Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients
This study looks at a talking therapy called Cognitive Enhancement Therapy (CET) for young people with early psychosis who also drink too much alcohol. It hopes to reduce alcohol use and improve recovery.
Canada - recruitingPHASE2
Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder
This study is looking into whether a single dose of a substance called psilocybin, alongside therapy, can help people with alcohol use disorder reduce their heavy drinking. They want to see if it makes a real difference.
Canada - not yet recruiting
Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder
This study looks at how personal traits like anxiety or self-esteem affect how people with alcohol use disorder learn and adapt. Participants will complete tasks and questionnaires once to help researchers better understand the condition.
France - not yet recruitingNA
Towards a Targeted Ultrasound Neuromodulation Intervention for Alcohol Abuse Disorders
This study is testing a new way to help people with alcohol use disorder, sometimes called alcohol addiction. It uses gentle sound waves, like those used in scans, to target specific brain areas. The aim is to see if this can help reduce cravings and improve control over drinking.
United Kingdom - recruitingNA
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
This study looks at why some people with head and neck cancer have ongoing pain after radiotherapy. It also checks if this pain is linked to continuing to smoke or drink alcohol, feeling low, very tired, or affecting their quality of life. Participants will answer questionnaires.
France - not yet recruitingNA
Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use
This study looks at how feeling left out affects people's desire for alcohol, especially those with alcohol problems. Researchers use an online ball-tossing game to make people feel included or excluded, then check their reactions and alcohol cravings.
Germany - recruitingNA
Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment
This study looks at people with alcohol or cannabis use problems. We want to see if understanding their thinking styles, motivations, and emotional reactions better helps us predict who responds best to therapy. Participants will receive 12 weeks of talking therapy.
Canada - recruitingNA
Social Cognition in Severe Alcohol Use Disorder
This study looks at how alcohol use disorder affects people's social skills and brain function. It aims to understand why some people find social situations difficult and how this might link to drinking habits, hoping to find new ways to help.
France - recruiting
Alcohol Use Disorder Before and After Bariatric Surgery and the Impact of Considering This Surgery During Addiction Follow-up
This study looks at medical records of people who had weight-loss surgery and also received help for alcohol problems. Researchers want to see how their surgery was considered during their alcohol treatment to improve future care.
France - recruitingNA
Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis
This study looks at a new type of therapy called ABCR for young people (aged 16-30) with early psychosis who also use alcohol or cannabis. It wants to see if ABCR can help reduce their substance use and improve their overall well-being.
Canada - recruitingNA
Bright Light Therapy During Residential Alcohol Withdrawal
This study is looking at whether bright light therapy can help people going through alcohol withdrawal in hospital. Participants will receive either real bright light or a dummy light each morning for about two weeks, alongside their usual care.
France - active not recruitingNA
Probiotic Study in Alcohol Recovery
This study looks at whether a daily probiotic capsule can help people who want to reduce their alcohol use. It aims to see if these 'good bacteria' can lessen cravings and improve mood, thinking, and overall well-being in adults who drink alcohol heavily.
United Kingdom - authorisedPhase II and Phase III (Integrated)
CIRAANO: Multimodal exploration (including radiopharmaceuticals Amyvid® and Tauvid®) of theater actors, memory athletes, and patients with various memory pathologies: evaluation of mnesic strategies and their cerebral substrates, and contribution to the treatment of memory pathologies.
This study looks at memory in different groups, including actors, memory athletes, and people with memory problems like Alzheimer's. It uses special brain scans to understand how different memory strategies work in the brain and how this might help treat memory conditions.
France - recruiting
Nottingham Community Liver Biomarkers Cohort
This study in Nottingham looks at improving how we find liver disease early in the community. It involves people with risk factors like heavy alcohol use, obesity, or diabetes, to see if new blood and scan tests can help identify liver problems before they become serious.
United Kingdom - not yet recruiting
Exploration of Acceptability of Alcohol Interventions
This study looks at how staff feel about using certain alcohol support methods and how well people from different backgrounds connect with an NHS alcohol service in North West England. It helps understand why some people get support and others don't.
United Kingdom - recruitingNA
Deep Brain Stimulation to Understand and Treat Addiction
This study is looking at whether a treatment called deep brain stimulation (DBS) can help people with severe alcohol use disorder. DBS uses gentle electrical signals to change brain activity. The aim is to see if it can reduce drinking for those who haven't been helped by other treatments.
United Kingdom