- recruitingTherapeutic exploratory (Phase II)
I5T-MC-AACI: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease
This study, called I5T-MC-AACI, is looking at a new medicine called Donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe, how well people tolerate it, and if it helps with symptoms. It's a Phase II study, which means it's still in early testing.
Netherlands · Czechia · Poland - recruitingPHASE3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
This study looks at a new medicine for agitation in people with Alzheimer's. It aims to see if an experimental drug, given as capsules, is safe and works well over a long time for those who've been in similar studies before.
United States · Argentina · Brazil - active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
Argentina · Australia · China - recruitingTherapeutic exploratory (Phase II)
I9X-MC-MTAE: Assessment of Safety, Tolerability, and Efficacy of LY3372689 in Early Symptomatic Alzheimer’s Disease
This study is looking into a new medication for people in the early stages of Alzheimer's disease. Researchers want to see if the medication, called LY3372689, is safe, has side effects, and if it helps improve or slow down symptoms compared to a dummy treatment.
Poland - active not recruitingPHASE3
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This study is testing a new medicine, AR1001, for people in the early stages of Alzheimer's disease. We want to see if it's safe and helps improve or slow down symptoms compared to a dummy medicine.
United States · Canada · China - recruitingNA
CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders
This study aims to improve how older people with memory problems, like Alzheimer's, move between different healthcare services in Quebec, Canada. It's testing a special program to make care smoother and better for patients and their families.
Canada - recruitingPHASE2
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study is looking at a new way to help people with Alzheimer's disease who feel unmotivated or apathetic. It combines a brain stimulation method with a commonly used medicine to see if it can improve these feelings.
Canada - recruitingNA
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This study looks at a special type of brain stimulation, called Deep TMS, for people over 60 with both depression and early Alzheimer's or memory problems. It's for those whose depression hasn't improved with usual treatments. We want to see if it's safe and helps with mood.
Canada - recruitingPHASE1, PHASE2
Study of ARO-MAPT-SC in Healthy Subjects and Subjects With Early Alzheimer's Disease
This study is looking at a new treatment called ARO-MAPT-SC for early Alzheimer's disease. Researchers want to see if it's safe, how the body handles it, and if it could help people with this condition.
Canada · New Zealand - recruitingNA
dTMS for Subjective Cognitive Decline
This study explores if a special brain stimulation (dTMS) combined with brain exercises can help older adults with memory concerns and a family history of Alzheimer's disease. Researchers want to see if it improves memory, thinking skills, and mood.
Canada - recruiting
German Registry of Alzheimer's Disease Treated With Transcranial Pulse Stimulation
This study looks at a treatment called Transcranial Pulse Stimulation (TPS) for Alzheimer's disease. Researchers want to see if it's safe, how well it works, and how practical it is in real-world settings. They will also keep track of any side effects.
Germany - recruiting
Designing a Tailored Primary Care Intervention to Manage the Burden of Caring for Patients Living with Alzheimer's Disease (or a Related Dementia)
This study aims to develop the best ways to support family carers of people with Alzheimer's disease or similar dementias. It involves asking experts and carers what they think about different support ideas to create a helpful program for GP surgeries.
France - recruiting
ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions
This study, ECOCAPTURE@HOME, looks at apathy in people with dementia. It uses wearable sensors and a smartphone app to understand how apathy affects daily life and carers. The aim is to find better ways to diagnose and monitor apathy.
France - recruitingNA
Longitudinal Study Examining At-Home tDCS
This study looks at how a treatment called tDCS might help people with Alzheimer's and other dementias when used at home. We're helping participants get their own tDCS devices and teaching them how to use them, then checking in regularly to see if it helps with their symptoms over two years.
Canada - active not recruiting
Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION
This study, called DECISION, looks into how people with Alzheimer's and similar conditions make decisions. It aims to create a simple test to check if someone can understand and agree to healthcare choices. This is important for their rights and involvement in their care.
Germany - recruiting
Optical Neuroimaging and Cognition
This study looks at how brain oxygen and energy use change in people with Alzheimer's, Lewy Body Dementia, and Mild Cognitive Impairment. We're using new, gentle scanning methods to better understand these conditions and find ways to help with diagnosis and monitoring.
United Kingdom - not yet recruiting
Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients
This study looks at people with Alzheimer's disease to understand what affects their memory and thinking scores. Researchers will check medical records to see if factors like age, education, and mood history are linked to their initial score and how quickly it changes over a year.
France - active not recruitingPHASE2
A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD)
This study, ALTITUDE-AD, is testing a new medicine called sabirnetug to see if it can slow down memory and thinking problems in people with early Alzheimer's disease. Participants will receive either sabirnetug or a dummy medicine every four weeks to compare their effects.
United States · Canada · Germany - recruitingNA
rTMS for Apathy Clinical Trial
This study looks at a brain stimulation treatment called rTMS for people with memory problems and a lack of interest, known as apathy. It aims to see if rTMS can help improve apathy, especially for those already taking medication or not.
Canada - active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
This study is looking at a new medicine called donanemab for people in the early stages of Alzheimer's disease. Researchers want to find out if it's safe and effective at treating the condition. Some people will get the medicine, and others a dummy treatment.
United States · Australia · Canada - recruiting
Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
This study looks at how people with certain types of dementia, like frontal lobe dementia (bvFTD) and Alzheimer's, understand their own thoughts and feelings, especially about social situations. It uses computer tasks to see how people recognise emotions and how sure they feel about their answers.
France - enrolling by invitation
Alzheimer's Disease Neuroimaging Initiative 4
ADNI4 is a research study building on previous work to better understand Alzheimer's disease. It involves looking at memory, brain scans, and blood tests in people with normal memory, mild memory problems, and dementia, to find better ways to detect and treat these conditions.
United States · Canada - recruitingNA
Lived Experience Narratives in Dementia
This study is called LEND and looks into how sharing personal stories can help people with dementia and their carers. It aims to create an online tool using these stories to improve well-being. Researchers are talking to people and developing an app to see if it helps, with the goal of making it widely available.
United Kingdom - recruitingNA
Investigation of AlzHeimer's Predictors in Subjective Memory Complainers - Extension Study
This study is looking into how Alzheimer's disease develops in people who have noticed changes in their memory. It involves following people who were part of a previous study for several more years to see if they develop Alzheimer's.
France - active not recruiting
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
This study investigates a new imaging technique, Cortical Disarray Measurement (CDM), to improve the early diagnosis of Alzheimer's disease in people with memory problems. It aims to see if CDM can identify early changes and how these relate to memory over two years, helping us better understand and diagnose Alzheimer’s.
United Kingdom - recruitingNA
Understanding How Alzheimer's Disease Impacts the Therapeutic Response to Transcranial Direct Current Stimulation
This study is looking into a new way to help people with Alzheimer's disease using a gentle electrical treatment called tDCS. We want to see if a slightly stronger dose of this treatment works better to improve memory and thinking skills, especially when combined with brain training exercises.
Canada - recruiting
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
This study looks at the germs in the mouths of older people, comparing those with and without Alzheimer's disease. Researchers hope to find a link between mouth germs and Alzheimer's to help with early detection and understanding of the disease.
France - recruitingPHASE1, PHASE2
A Study to Assess Safety and Tolerability and to Explore Efficacy of NSC001 in Mild to Moderate Alzheimer's Disease
This study is looking into a new medication called NSC001 for people with mild to moderate Alzheimer's disease. Researchers want to see if it's safe, how well people tolerate it, and if it could help improve memory and thinking.
Austria · Germany - recruiting
Tanycytes in Alzheimer's Disease and Frontotemporal Dementia
This study looks into how certain brain cells, called tanycytes, might be involved in Alzheimer's disease and a similar condition called frontotemporal dementia. Researchers want to see if how these cells handle a hormone called leptin changes early in these diseases.
France - recruitingNA
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
This study looks at how Alzheimer's disease affects someone's thinking speed and how this links to changes in their brain. Researchers usually check this through brain scans, memory tests, and blood checks.
France - recruiting
Biobank and Brain Health in Bordeaux.
This study, called "B cube," looks at how our brains change as we get older, especially from age 55. Researchers want to understand why some people's memories and thinking skills decline and how to prevent it. They are studying 2000 people in Bordeaux, France, focusing on things like diet and overall health.
France - recruiting
Trial-Ready Cohort-Down Syndrome (TRC-DS)
This study looks at adults with Down syndrome to understand how Alzheimer's disease develops. It aims to find better ways to measure changes in the brain for future drug trials, helping to speed up the search for effective treatments.
United States · France · Ireland - recruitingNA
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
This study looks at whether regular exercise can help prevent memory decline and Alzheimer's disease in older adults. We want to see if being more active can keep your brain healthier.
Canada - recruitingNA
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
This study looks at how the tiny blood vessels and structure at the back of the eye might be linked to memory problems and conditions like Alzheimer's. Researchers are using special eye scans to see if these eye changes can help us understand memory issues better.
France - recruitingPHASE1
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
This study is testing a new drug, NIO752, to see if it can reduce a protein called tau in the brains of people with early Alzheimer's disease. Too much tau builds up in Alzheimer's and causes damage. We want to see if this drug can help prevent that.
United States · United Kingdom - active not recruitingPHASE2
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease
This study is testing a new medicine, JNJ-64042056, for people who are at very early stages of Alzheimer's disease. Researchers want to see if the medicine can stop a specific brain protein, called tau, from building up and spreading, which is linked to the condition.
United States · Australia · Belgium - recruitingPHASE1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
This study looks at a new medicine called LY3954068 for people with early Alzheimer's disease. Researchers want to see if it's safe, how it moves through the body, and if it affects signs of the disease. Participants will receive the medicine or a dummy treatment through an injection into the spinal fluid.
United States · Japan · United Kingdom - recruiting
Detecting Early Alzheimer's Using MR
This study is testing a new, safer MRI scan called glucoCEST to find early signs of Alzheimer's disease. Currently, detecting early Alzheimer's can be tricky. This new scan looks at how the brain uses sugar without using radiation, hoping to find the disease sooner and help people get treatment earlier.
United Kingdom - recruiting
IONA Longitudinal Cohort Study
The IONA study in Scotland is looking at how memory and thinking decline. Researchers are collecting health, lifestyle, and genetic information from people over 50. The goal is to better understand dementia and eventually help develop new treatments for conditions like Alzheimer's disease.
United Kingdom - active not recruiting
Longitudinal Early-onset Alzheimer's Disease Study Protocol
This study looks at how early-onset Alzheimer's disease develops over time. It compares people with this condition to those without it, gathering information on memory, brain scans, and other health markers to better understand the disease.
United States · Argentina · Netherlands - recruitingPHASE3
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
This study is looking at a new treatment called KarXT + KarX-EC for psychosis, which can affect people with Alzheimer's disease. Researchers want to see if this treatment is safe and helps reduce psychotic symptoms like hallucinations or delusions in individuals aged 55 to 90.
United States · Australia · Canada - active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)
This study is testing a new medicine called MK-1167 for people with Alzheimer's disease. Researchers want to see if it can improve memory and thinking when taken with standard treatment and if it's safe and well-tolerated.
United States · Argentina · Canada - recruitingNA
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
This study looks at how gut health, especially methane gas levels, might be linked to Parkinson's disease and memory problems. It also tests if a probiotic can help reduce methane. We want to understand if gut issues affect how these conditions develop and progress.
United Kingdom