- active not recruitingPHASE2
Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. a Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group
This study is testing if adding a drug called durvalumab to standard treatment (chemotherapy and radiation) works better for advanced anal cancer. Researchers want to see if this new combination improves how well people respond to treatment.
Austria · Germany · Switzerland - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - recruitingNA
Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy
This study looks at whether using a special tampon during radiotherapy for anal cancer can help prevent vaginal narrowing. Researchers want to see if a slightly larger tampon helps keep the vagina more open compared to a standard one, aiming to improve patients' quality of life after treatment.
Germany - recruiting
Prospective Observational Trial to Evaluate Quality of Life After Definitive Chemoradiation in Patients With Anal Cancer (LANACARE)
This study looks at how quality of life changes for people with anal cancer receiving a treatment called chemoradiation. Researchers will use questionnaires to understand how patients feel, how well their body works, and how successful the treatment is over time.
Germany - recruitingNA
Host Genome Methylation: a Screening Tool in Anal Cancer Detection
This study looks into new ways to spot anal cancer early using an at-home test. Researchers are investigating if specific genetic markers in anal smear samples can help find people at higher risk, especially those already eligible for screening, to guide them to further checks.
France - authorisedPhase I and Phase II (Integrated)- Bioequivalence Study
PHASE 1B/II TRIAL OF CHECKPOINT INHIBITOR (PEMBROLIZUMAB AND ANTI PD-1 ANTIBODY) PLUS STANDARD IMRT IN HPV INDUCED STAGE III SQUAMOUS CELL CARCINOMA OF ANUS
This study looks at a new way to treat anal cancer caused by HPV. It combines a standard radiation and chemotherapy treatment with a new drug called pembrolizumab (Keytruda). The main goal is to see if this combination treatment is safe and well-tolerated.
Norway - recruitingNA
Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.
This study looks at whether women over 40 with certain vulvar conditions are at higher risk for anal cancer. It aims to see if regular anal screening, like a Pap test for the bottom, could help find and treat problems early in this group.
Canada - active not recruitingPHASE1
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
This study looks at a new drug, KFA115, on its own and with another drug, pembrolizumab, for various advanced cancers. It aims to find a safe and effective dose, helping doctors understand how these treatments work.
United States · Canada · China