Atherosclerotic Cardiovascular Disease research hub
7 indexed studies · 2 currently recruiting
- active not recruitingPHASE3
REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification
The REVEAL trial looked at whether a drug called anacetrapib could help people with existing heart and circulatory problems. It aimed to see if this drug, when added to usual statin treatment, could lower their risk of serious heart events like heart attacks. The study has now finished.
United Kingdom - enrolling by invitation
Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular Disease
This study is following people who've had an experimental gene therapy for certain heart conditions. It checks how the treatment affects them over a long time, up to 15 years, looking for any lasting benefits or side effects to make sure it's safe and works well.
New Zealand · United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, placebo-controlled, parallel-group, investigator- and participant-blinded Phase 2a study to investigate the efficacy, safety, and tolerability of DFV890 and MAS825 for inflammatory marker reduction in an adult population with coronary heart disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
This study is testing new medicines, DFV890 and MAS825, for adults with heart disease and a blood condition called CHIP. We want to see if these medicines can lower inflammation and if they are safe. Some people will get a dummy treatment (placebo) for comparison.
Germany - active not recruitingPHASE3
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
This study is testing a new medicine called olpasiran to see if it can help people with heart disease and high levels of a specific fat in their blood, called Lp(a). We want to find out if olpasiran can lower the risk of heart attacks and other heart problems.
United States · Argentina · Australia - active not recruitingPHASE3
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease
This study, ORION-4, will test if a new injection called inclisiran can safely lower the risk of heart attacks and strokes in people who have already had these conditions or related treatments. It's for people with heart and blood vessel problems.
United States · United Kingdom - active not recruitingPHASE3
Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease
This study is looking at a new medicine called Obicetrapib for people with heart disease. It aims to see if this medicine can help reduce serious heart problems like heart attacks and strokes, especially for those whose cholesterol isn't well-controlled with their usual treatments.
United States · Australia · Bulgaria - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia