- authorisedTherapeutic confirmatory (Phase III)
Colchicine after Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial
This study looks at whether an anti-inflammatory medicine called colchicine can help keep your heartbeat regular after an electrical cardioversion. Cardioversion is a routine treatment that resets the heart's rhythm. Researchers want to see if taking colchicine daily for six months stops atrial fibrillation from returning better than a dummy pill.
Germany - authorisedTherapeutic confirmatory (Phase III)
Multicenter and randomised study on atrial fibrillation prevention after cardiac surgery with a 3-way comparison between standard of care, posterior pericardiotomy and a treatment bundle (colchicine, amiodarone and posterior pericardiotomy) (PREV-AF)
This study looks at the best ways to stop an irregular heartbeat, called atrial fibrillation, after heart surgery. Researchers are comparing standard NHS care with a small surgical cut to drain fluid, and a package combining this cut with heart medicines, to see which keeps heart rhythms normal best.
France - active not recruitingPHASE3
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
This study is comparing two medicines, milvexian and apixaban, for people with an irregular heartbeat called atrial fibrillation. We want to see if milvexian is just as good as apixaban at stopping serious problems like strokes, which can happen with this condition.
United States · Argentina · Australia - recruitingPhase IV
Preventing stroke, premature death and cognitive decline in a broader community of patients with atrial fibrillation (DaRe2THINK)
Atrial fibrillation (AF) is a heart condition that raises the risk of stroke and memory problems. The DaRe2THINK study tests whether starting modern blood-thinning tablets earlier in people aged 55 to 73 can protect against stroke, blood clots, and dementia, using simple remote NHS check-ins.
United Kingdom · England - recruiting
PulseSelect™ PFA Global Registry
This study is observing how well a new treatment called PulseSelect™ PFA works for people with atrial fibrillation (an irregular heartbeat). It collects information on its safety and effectiveness in patients receiving this approved treatment as part of their routine care.
Australia · Belgium · Canada - recruiting
Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation
This study looks at how heart valve problems, called mitral and tricuspid regurgitation, affect people with an irregular heartbeat (atrial fibrillation). Researchers want to understand these conditions better and find out what causes them to get worse.
United Kingdom - recruitingNA
The Fourth Left Atrial Appendage Occlusion Study
This study looks at whether a 'WATCHMAN device' can prevent strokes in people with atrial fibrillation who are already taking blood thinners but still have a high stroke risk. It aims to see if blocking off a small part of the heart called the left atrial appendage helps.
United States · Belgium · Canada - recruitingNA
Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
This study looks at how different types of exercise, like moderate steady workouts or short bursts of high-intensity activity, affect people with ongoing atrial fibrillation. We want to see if exercise can improve fitness and quality of life for these patients.
Canada - recruitingNA
RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation
This study looks at a new online tool called RAPID AFib. It aims to help people with an irregular heartbeat (atrial fibrillation) and their doctors make good decisions about medicines to prevent strokes. We want to see if this tool is easy to use and helps patients understand their choices better.
Canada - recruitingNA
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
This study looks into the best way to shock the heart back to a normal rhythm for people with atrial fibrillation. We're testing different pad placements on the chest and if pressing on the pads helps the treatment work better.
Canada - recruiting
Tracking Results of Ablations to Combat AF Registry Generation 2
This study, called TRAC-AF, aims to track the long-term safety and effectiveness of certain heart procedures for people with atrial fibrillation (an irregular heartbeat). It looks at different types of surgery that use special medical devices to help correct the heart's rhythm.
United States · Canada - recruitingNA
Surgical Ablation of AF Efficacy Trial
This study looks at whether a surgical procedure to treat an irregular heartbeat (atrial fibrillation) during heart surgery can help prevent future heart problems, especially heart failure. It compares adding this procedure to not adding it, in people already having heart surgery.
Canada - recruitingNA
BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software
This study looks at heart failure patients without special heart devices. We want to understand irregular heartbeats and develop a tool to predict when heart failure might get worse, helping doctors intervene sooner to improve care.
Belgium · Germany - recruiting
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
This study looks at whether special scans (CT and MRI) can help doctors better understand who might benefit most from a common heart procedure called AF ablation. It aims to see if fat in the heart or how the heart muscle moves can predict how well the treatment works.
France - active not recruiting
Tracking Atrial Fibrillation After Intensive Care Admission
This study looks at heart rhythm problems called atrial fibrillation (AF) in people after intensive care. It aims to see how many people develop AF and if it comes back once they leave hospital, to help prevent serious issues like strokes later on.
United Kingdom - recruitingNA
BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF
This study looks at a new heart treatment called Pulsed Field Ablation (PFA) using the Volt PFA System for people with irregular heartbeats (atrial fibrillation). It aims to see how safe and effective it is in real-world use for different patients.
Austria · Belgium · Denmark - not yet recruiting
VOLta Medical AI-software in REal-World During AF Ablation
This study looks at how well a new AI software, Volta AF-Xplorer II, works during a heart procedure called a catheter ablation for atrial fibrillation. We want to see how safe and effective it is in real-life practice over two years.
France - recruitingNA
The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF
This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It explores whether targeting specific nerve endings in the right side of the heart can help people whose AF has returned after standard treatments.
United Kingdom - active not recruitingNA
CHAMPION-AF Clinical Trial
This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.
United States · Australia · Belgium - recruitingNA
Smartwatches for Detection of Atrial Fibrillation (AFib) in Secondary Prevention of Cryptogenic Stroke
This study looks at whether smartwatches can reliably find a heart condition called Atrial Fibrillation (AFib) in people who have had a stroke or 'mini-stroke' (TIA). Finding AFib is important to help prevent future strokes.
Germany - recruiting
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This study looks at how well a small heart monitor, called an Implantable Cardiac Monitor (ICM), works in real life for patients in the UK. It helps doctors understand its performance and safety over time, especially for conditions like irregular heartbeats or fainting spells.
Australia · Czechia · France - active not recruitingPHASE4
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
This study looks at whether a blood-thinning medicine called edoxaban can reduce the risk of stroke in people with an irregular heartbeat (atrial fibrillation) who have previously had bleeding in the brain. It compares edoxaban to not taking blood thinners.
United States · Argentina · Austria - recruitingPHASE3
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study looks at treating an irregular heartbeat called atrial fibrillation (AF) early after a stroke. We want to see if quick treatment of AF can stop future strokes and other heart problems better than the usual care.
Germany - active not recruiting
Affera Global Registry
This study looks at how well a device called the Affera Platform works for people with an irregular heartbeat called Atrial Fibrillation. It aims to gather real-world information on its safety and how effective it is in different patients after it's been approved for use.
Austria · Belgium · Czechia - recruitingNA
Ablate and Pace HIS Study
This study looks at a new way of fitting pacemakers for people with a heart condition called atrial fibrillation (AF) who also have signs of heart failure. It compares a standard pacemaker fitting with a newer method called His bundle pacing to see which works best.
United Kingdom - authorisedTherapeutic use (Phase IV)
Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure (SAFE-LAAC). Comparative Health Effectiveness Randomized Trial – PILOT Study
This study looks at how different blood-thinning medicines, aspirin and clopidogrel, work after a procedure to close off a part of the heart called the left atrial appendage. We want to find the best way to prevent strokes while also reducing bleeding, for people with an irregular heartbeat called atrial fibrillation.
Poland - recruiting
Clinical Cohort Study - TRUST
The TRUST study is looking at heart rhythm problems like atrial fibrillation. It aims to understand how different treatments work over time for people in Hamburg, Germany. Researchers will collect information and samples to learn more about these conditions and improve care.
Germany - recruitingPHASE3
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.
United States · Brazil · Canada - active not recruitingNA
Dispersion Stability
This study looks at a treatment called ablation for an irregular heartbeat condition called atrial fibrillation (AF). Researchers are testing if treating specific areas of the heart will stop AF right away and keep it away for a year.
France - recruitingNA
Same-Day Discharge Versus Overnight Stay Following Pulmonary Vein Isolation for Atrial Fibrillation
This study compares going home the same day after a heart procedure for atrial fibrillation with staying overnight. It checks if same-day discharge is as safe and effective, and if it could make recovery easier and cost less.
Germany - recruitingNA
B2AD-Risk AFDAS Evolution of Burden of AF
This study looks at people who have had a stroke and then found out they have an irregular heartbeat called atrial fibrillation (AF). We want to understand how this AF changes over time to help improve treatments and prevention for future strokes.
Canada - recruiting
Atrial Fibrillation in Young Patients: a Prospective Multicentre Registry
This study looks at young people (under 35) with a heart condition called atrial fibrillation (AF). Researchers want to understand what causes it, how it's treated, and what happens to people with AF over time. It's an important step in helping young patients live well with this condition.
France - active not recruitingNA
Amplatzer Amulet LAAO vs. NOAC
This study compares a device that closes off a small pouch in the heart (Amplatzer Amulet) with standard blood-thinning medicines (NOACs). It aims to see which is safer and better at preventing strokes in people with an irregular heartbeat called atrial fibrillation.
United States · Australia · Canada - recruiting
Long-Term Evaluation of TAILORED Vs Anatomical Ablation Strategy for Persistent Atrial Fibrillation
This study looks at how well different treatments for a heart condition called atrial fibrillation (AF) work over a long time. It compares a new, 'tailored' approach using AI to a standard treatment, aiming to see which keeps people free from AF for up to five years.
France · Germany - active not recruitingNA
Reversal of Atrial Substrate to Prevent Atrial
This study looks at how best to prevent atrial fibrillation (AF) recurring. It compares two approaches: an AF treatment called catheter ablation, and catheter ablation combined with an intense programme to improve lifestyle and health factors like diet and exercise.
Canada - recruitingNA
Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy
This study looks at whether a procedure to close off a part of the heart called the left atrial appendage (LAA) in addition to blood thinners can better prevent strokes in people with atrial fibrillation who have already had a stroke despite being on blood thinners.
Belgium · Germany · New Zealand - active not recruitingNA
Impact of Cardiac Prehabilitation, REhabilitation and Patient EDucation on Outcomes in Patients Undergoing First-time AF Ablation
This study looks at whether extra exercise and education before and after treatment for an irregular heartbeat (AF ablation) can lead to better results. It compares this special support to the usual care patients receive.
United Kingdom - recruiting
Non-invasive Differentiation of Supraventricular Tachyarrhythmia
This study aims to find better ways to diagnose irregular heartbeats, like atrial fibrillation, using questionnaires and a special, detailed heart tracing called an extended ECG. It focuses on people undergoing treatment for these conditions to improve diagnosis without invasive procedures.
Germany - recruiting
CArdioSurgEry Atrial Fibrillation Register
This study looks at how people with an irregular heartbeat called atrial fibrillation are cared for after having surgery to fix it. Researchers want to understand the different reasons for this surgery, how often it's done, how safe it is, and how well it works over time.
Germany - recruitingNA
Diagnosis of Postoperative Atrial Fibrillation by a Smartwatch
This study looks at how smartwatches can help spot an irregular heartbeat called atrial fibrillation after heart surgery. It aims to see if these watches can find issues quickly, especially when patients are no longer in intensive care, helping doctors to act sooner.
France - active not recruitingNA
STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation
This study compares three ways of doing a heart procedure called catheter ablation for a type of irregular heartbeat called persistent atrial fibrillation. It aims to find out which method works best to help your heart beat normally.
United States · Australia · Austria - recruiting
AF Ablation With High Power Short Duration RF
This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It uses a special procedure called catheter ablation to see if a high-power, short-duration approach is safe and effective in preventing AF from coming back.
France · Italy · United Kingdom - recruitingNA
Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation
This study looks at how different types of exercise affect symptoms in men and women with atrial fibrillation (AF). Researchers want to see if moderate or high-intensity exercise changes AF symptoms in the short term, compared to not exercising much. This will help them plan bigger studies.
Canada - active not recruitingNA
Exercise Training in Patients With Atrial Fibrillation (OPPORTUNITY Study)
This study looks at how different types of exercise – steady, moderate exercise versus short bursts of intense exercise – affect people with atrial fibrillation. We want to see if exercise can improve fitness and quality of life for those with this common heart rhythm condition.
Canada - recruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
United States · Argentina · Australia - recruitingPHASE4
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
This study looks at whether newer blood thinners (DOACs) can help younger people with a heart rhythm problem called atrial fibrillation. It aims to prevent strokes, serious blood clots, and memory problems. The study uses patient health records and takes place entirely within the NHS.
United Kingdom - recruitingPHASE3
Avoiding Anticoagulation After IntraCerebral Haemorrhage
This study looks at the best way for people with a history of bleeding in the brain and an irregular heartbeat (atrial fibrillation) to prevent future strokes. It compares an anti-clotting drug (Apixaban), a heart procedure (left atrial appendage closure), and usual care.
France - recruiting
Post-marketing Clinical Study of the LAMBRE System for Left Auricle Closure
This study looks at how well a device called LAMBRE works to prevent strokes in people with a heart condition called atrial fibrillation. It's for patients who can't take blood-thinning medicines because of risks.
France - active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Australia · Austria · Belgium - active not recruiting
Volumetric Quantification of Epicardial Fat Using Semiautomated High Resolution Atrial CT Segmentation in Patients With Atrial Fibrillation Receiving Catheter Ablation
This study looks at how much fat is around the heart in people with atrial fibrillation before a procedure called catheter ablation. Researchers want to see if the amount of this fat affects how well the ablation works to stop irregular heartbeats.
Germany