- recruiting
oRIoN: An investigation into whether the methodology used in hypotonic saline cough challenge can be refined
This UK study looks at better ways to test cough sensitivity. Researchers at Wythenshawe Hospital want to improve a test where people breathe in a gentle salty mist. They are inviting both people with long-term, unexplained coughs and healthy volunteers to help make the test quicker and more reliable.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
Evaluation of the effect of CHF6795 on the pharmacokinetics of midazolam, repaglinide and rosuvastatin in healthy subjects
This study looks at how a new medicine, CHF6795, affects how common drugs like midazolam, repaglinide, and rosuvastatin work in the body. It involves healthy adults to understand these interactions before testing the medicine in people with chronic cough.
Belgium - not yet recruitingPHASE4
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
This study looks at new ways to help people with long-lasting coughs that haven't responded to usual treatments. It tests two medicines (low-dose morphine and pregabalin) and a special cough therapy, separately and together, to see which works best and is safest.
Canada - recruiting
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
This study aims to understand chronic cough, lasting over 8 weeks, by looking at inflammation in the lungs and a body chemical called ATP. Researchers will compare people with and without chronic cough to find out what causes it and explore new treatments.
United Kingdom - recruiting
An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough
This study aims to better understand chronic cough by looking at different cough patterns. We've created a new questionnaire to see how your cough type, how it changes over time, and how it affects your daily life are linked. We want to make sure the questionnaire is clear and helpful.
United Kingdom